CA6 (carbonic anhydrase 6) - Rat Genome Database

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Gene: CA6 (carbonic anhydrase 6) Canis lupus familiaris
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Symbol: CA6
Name: carbonic anhydrase 6
RGD ID: 12120256
Description: ENCODES a protein that exhibits carbonate dehydratase activity (inferred); zinc ion binding (inferred); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (inferred); one-carbon metabolic process (inferred); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CA-VI; carbonate dehydratase VI; carbonic anhydrase VI
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,358,521 - 62,379,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,358,403 - 62,379,897 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,375,992 - 62,397,372 (+)NCBI
ROS_Cfam_1.0562,580,266 - 62,606,464 (+)NCBI
UMICH_Zoey_3.1562,583,427 - 62,604,811 (+)NCBI
UNSW_CanFamBas_1.0562,447,719 - 62,469,108 (+)NCBI
UU_Cfam_GSD_1.0562,851,948 - 62,873,335 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:19874279  


Genomics

Comparative Map Data
CA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,358,521 - 62,379,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,358,403 - 62,379,897 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,375,992 - 62,397,372 (+)NCBI
ROS_Cfam_1.0562,580,266 - 62,606,464 (+)NCBI
UMICH_Zoey_3.1562,583,427 - 62,604,811 (+)NCBI
UNSW_CanFamBas_1.0562,447,719 - 62,469,108 (+)NCBI
UU_Cfam_GSD_1.0562,851,948 - 62,873,335 (+)NCBI
CA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl18,945,867 - 8,975,092 (+)EnsemblGRCh38hg38GRCh38
GRCh3818,945,868 - 8,975,092 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,005,927 - 9,035,151 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,928,509 - 8,957,738 (+)NCBINCBI36hg18NCBI36
Build 3418,940,207 - 8,969,412NCBI
Celera18,114,641 - 8,143,865 (+)NCBI
Cytogenetic Map1p36.23NCBI
HuRef18,155,174 - 8,184,890 (+)NCBIHuRef
CHM1_118,995,837 - 9,025,073 (+)NCBICHM1_1
Car6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,271,472 - 150,285,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl4150,271,472 - 150,285,789 (-)Ensembl
GRCm384150,187,015 - 150,201,135 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,187,015 - 150,201,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,561,124 - 149,575,244 (-)NCBIGRCm37mm9NCBIm37
MGSCv364149,030,815 - 149,042,270 (-)NCBImm8
Celera4152,461,682 - 152,476,184 (-)NCBICelera
Cytogenetic Map4E2NCBI
Ca6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,658,104 - 160,676,644 (-)NCBI
Rnor_6.0 Ensembl5167,226,246 - 167,244,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05167,226,246 - 167,244,786 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05170,854,181 - 170,872,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,332,219 - 167,350,880 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15167,342,413 - 167,361,042 (-)NCBI
Celera5158,915,352 - 158,933,838 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ca6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,234,235 - 4,247,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,234,293 - 4,249,026 (-)NCBIChiLan1.0ChiLan1.0
CA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.118,938,158 - 8,966,305 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,938,164 - 8,966,300 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v017,703,187 - 7,732,409 (+)NCBIMhudiblu_PPA_v0panPan3
Ca6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,675,341 - 32,703,732 (+)NCBI
SpeTri2.0NW_0049366233,169,095 - 3,188,947 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,447,439 - 69,468,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,447,662 - 69,468,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,673,124 - 63,695,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,777,961 - 122,817,689 (-)NCBI
ChlSab1.1 Ensembl20122,777,895 - 122,810,359 (-)Ensembl
Vero_WHO_p1.0NW_02366605426,799,675 - 26,832,454 (-)NCBI
Ca6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248183,179,847 - 3,193,699 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 3 2
Below cutoff 2 10 2 6 2 7 2 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000031340   ⟹   ENSCAFP00000029168
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl562,358,521 - 62,379,897 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000066961   ⟹   ENSCAFP00000050459
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl562,358,403 - 62,377,843 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000091102   ⟹   ENSCAFP00000043940
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl562,359,637 - 62,379,897 (+)Ensembl
RefSeq Acc Id: NM_001002999   ⟹   NP_001002999
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1562,358,521 - 62,379,901 (+)NCBI
Dog10K_Boxer_Tasha562,375,992 - 62,397,372 (+)NCBI
ROS_Cfam_1.0562,585,084 - 62,606,464 (+)NCBI
UMICH_Zoey_3.1562,583,427 - 62,604,811 (+)NCBI
UNSW_CanFamBas_1.0562,447,719 - 62,469,108 (+)NCBI
UU_Cfam_GSD_1.0562,851,948 - 62,873,335 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038664056   ⟹   XP_038519984
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0562,580,308 - 62,606,464 (+)NCBI
RefSeq Acc Id: XM_038664057   ⟹   XP_038519985
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0562,580,266 - 62,606,464 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001002999 (Get FASTA)   NCBI Sequence Viewer  
  XP_038519984 (Get FASTA)   NCBI Sequence Viewer  
  XP_038519985 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC65098 (Get FASTA)   NCBI Sequence Viewer  
  Q865C0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002999   ⟸   NM_001002999
- Peptide Label: precursor
- UniProtKB: Q865C0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000029168   ⟸   ENSCAFT00000031340
RefSeq Acc Id: ENSCAFP00000050459   ⟸   ENSCAFT00000066961
RefSeq Acc Id: ENSCAFP00000043940   ⟸   ENSCAFT00000091102
RefSeq Acc Id: XP_038519985   ⟸   XM_038664057
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038519984   ⟸   XM_038664056
- Peptide Label: isoform X1
Protein Domains
Alpha-carbonic anhydrase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000029168 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000043940 UniProtKB/TrEMBL
  ENSCAFP00000050459 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031340 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000066961 UniProtKB/TrEMBL
  ENSCAFT00000091102 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_CA6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403503 UniProtKB/Swiss-Prot
NCBI Gene CA6 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F4BQ90_CANLF UniProtKB/TrEMBL
  A0A5F4C8B3_CANLF UniProtKB/TrEMBL
  CAH6_CANLF UniProtKB/Swiss-Prot
  F1PCG9_CANLF UniProtKB/TrEMBL
  Q865C0 ENTREZGENE
VGNC ID VGNC:38614 ENTREZGENE