PLA2G12B (phospholipase A2 group XIIB) - Rat Genome Database

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Gene: PLA2G12B (phospholipase A2 group XIIB) Canis lupus familiaris
Analyze
Symbol: PLA2G12B
Name: phospholipase A2 group XIIB
RGD ID: 12119809
Description: ENCODES a protein that exhibits calcium ion binding (inferred); phospholipase A2 activity (inferred); INVOLVED IN cholesterol homeostasis (ortholog); low-density lipoprotein particle remodeling (ortholog); triglyceride homeostasis (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: group XIIB secretory phospholipase A2-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,539,909 - 23,561,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,541,258 - 23,561,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,827,748 - 23,847,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLA2G12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,539,909 - 23,561,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,541,258 - 23,561,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,827,748 - 23,847,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBIUU_Cfam_GSD_1.0
PLA2G12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,934,762 - 72,954,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,934,762 - 72,954,806 (-)EnsemblGRCh38hg38GRCh38
GRCh371074,694,520 - 74,714,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,364,944 - 74,384,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,364,943 - 74,384,516NCBI
Celera1067,980,077 - 67,999,649 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,688,779 - 68,708,351 (-)NCBIHuRef
CHM1_11074,976,668 - 74,996,240 (-)NCBICHM1_1
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBIT2T-CHM13v2.0
Pla2g12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,239,242 - 59,257,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,239,482 - 59,257,798 (+)EnsemblGRCm39 Ensembl
GRCm381059,403,420 - 59,421,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,403,660 - 59,421,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371058,866,433 - 58,884,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,799,042 - 58,817,333 (+)NCBIMGSCv36mm8
Celera1060,503,964 - 60,522,245 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.54NCBI
Pla2g12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,910,620 - 27,931,734 (+)NCBIGRCr8
mRatBN7.22027,369,196 - 27,389,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,370,266 - 27,388,743 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02028,989,440 - 29,007,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,989,491 - 29,007,968 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,793,778 - 30,812,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,813,714 - 28,832,140 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pla2g12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,694,496 - 18,719,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,694,496 - 18,723,311 (+)NCBIChiLan1.0ChiLan1.0
PLA2G12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,111,134 - 85,130,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,116,402 - 85,135,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,482,065 - 69,502,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,946,072 - 71,965,616 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,946,506 - 71,965,482 (-)Ensemblpanpan1.1panPan2
Pla2g12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,579,733 - 57,604,031 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,072,486 - 6,096,791 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,072,487 - 6,096,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,753,727 - 75,778,800 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,754,525 - 75,778,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,819,851 - 81,844,252 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,311,609 - 58,335,286 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,312,500 - 58,336,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,907,588 - 18,935,677 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,653,698 - 6,680,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,653,307 - 6,680,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G12B
190 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000050207   ⟹   ENSCAFP00000039510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl423,541,258 - 23,561,041 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845010570   ⟹   ENSCAFP00845008230
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl423,827,748 - 23,847,930 (-)Ensembl
RefSeq Acc Id: XM_005619005   ⟹   XP_005619062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1423,539,909 - 23,561,211 (-)NCBI
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038474370   ⟹   XP_038330298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBI
RefSeq Acc Id: XM_038474371   ⟹   XP_038330299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBI
RefSeq Acc Id: XM_038533727   ⟹   XP_038389655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBI
RefSeq Acc Id: XM_038533728   ⟹   XP_038389656
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBI
RefSeq Acc Id: XM_038598027   ⟹   XP_038453955
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBI
RefSeq Acc Id: XM_038598028   ⟹   XP_038453956
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBI
RefSeq Acc Id: XM_038662334   ⟹   XP_038518262
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBI
RefSeq Acc Id: XM_038662335   ⟹   XP_038518263
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBI
RefSeq Acc Id: XM_546163   ⟹   XP_546163
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1423,539,909 - 23,561,210 (-)NCBI
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005619062   ⟸   XM_005619005
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LMQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_546163   ⟸   XM_546163
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PP53 (UniProtKB/TrEMBL),   A0A8I3RSZ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000039510   ⟸   ENSCAFT00000050207
RefSeq Acc Id: XP_038330299   ⟸   XM_038474371
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038330298   ⟸   XM_038474370
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038453956   ⟸   XM_038598028
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038453955   ⟸   XM_038598027
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038518263   ⟸   XM_038662335
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LMQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518262   ⟸   XM_038662334
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PP53 (UniProtKB/TrEMBL),   A0A8I3RSZ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389656   ⟸   XM_038533728
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LMQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389655   ⟸   XM_038533727
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PP53 (UniProtKB/TrEMBL),   A0A8I3RSZ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845008230   ⟸   ENSCAFT00845010570

Promoters
RGD ID:13682917
Promoter ID:EPDNEW_C987
Type:multiple initiation site
Name:PLA2G12B_1
Description:phospholipase A2 group XIIB
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1423,561,138 - 23,561,198EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000031548 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011069 UniProtKB/TrEMBL
  ENSCAFG00040000910 UniProtKB/TrEMBL
  ENSCAFG00845005974 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000050207.3 UniProtKB/TrEMBL
  ENSCAFT00030020518.1 UniProtKB/TrEMBL
  ENSCAFT00040001643.1 UniProtKB/TrEMBL
  ENSCAFT00845010570 ENTREZGENE
  ENSCAFT00845010570.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLA2G12 UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
NCBI Gene PLA2G12B ENTREZGENE
PANTHER GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN UniProtKB/TrEMBL
  PTHR12824 UniProtKB/TrEMBL
Pfam PLA2G12 UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A8C0LMQ4 ENTREZGENE
  A0A8C0PP53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RSZ9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44620 ENTREZGENE