UMPS (uridine monophosphate synthetase) - Rat Genome Database
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Gene: UMPS (uridine monophosphate synthetase) Canis lupus familiaris
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Symbol: UMPS
Name: uridine monophosphate synthetase
RGD ID: 12117812
Description: ENCODES a protein that exhibits identical protein binding (ortholog); orotate phosphoribosyltransferase activity (ortholog); orotidine-5'-phosphate decarboxylase activity (ortholog); INVOLVED IN cellular response to drug (ortholog); female pregnancy (ortholog); lactation (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH Acute Erythroblastic Leukemia (ortholog); beta thalassemia (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: uridine 5'-monophosphate synthase; uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3327,754,643 - 27,782,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13327,754,592 - 27,782,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References

Genomics

Comparative Map Data
UMPS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3327,754,643 - 27,782,514 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13327,754,592 - 27,782,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
UMPS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3124,730,433 - 124,749,273 (+)EnsemblGRCh38hg38GRCh38
GRCh383124,730,442 - 124,749,273 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373124,449,299 - 124,468,120 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh373124,449,213 - 124,468,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363125,931,903 - 125,946,318 (+)NCBINCBI36hg18NCBI36
Build 343125,931,902 - 125,946,318NCBI
Celera3122,856,384 - 122,875,279 (+)NCBI
Cytogenetic Map3q21.2NCBI
HuRef3121,823,485 - 121,842,386 (+)NCBIHuRef
CHM1_13124,412,201 - 124,431,088 (+)NCBICHM1_1
Umps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391633,775,152 - 33,787,408 (-)NCBIGRCm39mm39
GRCm381633,954,782 - 33,967,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,954,782 - 33,967,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv371633,955,098 - 33,967,089 (-)NCBIGRCm37mm9NCBIm37
MGSCv361633,874,759 - 33,886,750 (-)NCBImm8
Celera1634,439,142 - 34,451,132 (-)NCBICelera
Cytogenetic Map16B3NCBI
Umps
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,806,107 - 66,816,520 (+)NCBI
Rnor_6.0 Ensembl1170,034,139 - 70,044,628 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01170,034,181 - 70,044,590 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01173,123,827 - 73,134,236 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,619,835 - 68,630,244 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11168,677,423 - 68,687,833 (+)NCBI
Celera1166,256,748 - 66,267,157 (+)NCBICelera
Cytogenetic Map11q22NCBI
Umps
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542723,825,523 - 23,841,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542723,825,529 - 23,841,427 (+)NCBIChiLan1.0ChiLan1.0
UMPS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13128,731,309 - 128,745,241 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3128,731,355 - 128,745,029 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03121,832,758 - 121,851,707 (+)NCBIMhudiblu_PPA_v0panPan3
Umps
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936725553,278 - 564,846 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UMPS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13135,610,058 - 135,650,604 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113135,611,857 - 135,650,656 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213145,113,405 - 145,154,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UMPS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12256,081,897 - 56,097,164 (-)NCBI
ChlSab1.1 Ensembl2256,082,103 - 56,097,105 (-)Ensembl
Umps
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624731761,235 - 780,355 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 2 20 4 6 4 6 6 12 10 6
Low 3 2 2 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019720   ⟹   ENSCAFP00000018290
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3327,754,643 - 27,782,514 (+)Ensembl
RefSeq Acc Id: XM_535769   ⟹   XP_535769
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13327,754,592 - 27,782,517 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038301121 (Get FASTA)   NCBI Sequence Viewer  
  XP_038375371 (Get FASTA)   NCBI Sequence Viewer  
  XP_038438990 (Get FASTA)   NCBI Sequence Viewer  
  XP_038503408 (Get FASTA)   NCBI Sequence Viewer  
  XP_535769 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_535769   ⟸   XM_535769
- UniProtKB: E2RRY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000018290   ⟸   ENSCAFT00000019720
Protein Domains
OMPdecase

Promoters
RGD ID:13688830
Promoter ID:EPDNEW_C6899
Type:multiple initiation site
Name:UMPS_1
Description:uridine monophosphate synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13327,754,625 - 27,754,685EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000018290 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019720 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
  3.40.50.2020 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  OMPdecase UniProtKB/TrEMBL
  OMPdecase_AS UniProtKB/TrEMBL
  OMPdeCOase_dom UniProtKB/TrEMBL
  OPRT UniProtKB/TrEMBL
  Or_phspho_trans_dom UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/TrEMBL
  PRTase-like UniProtKB/TrEMBL
  RibuloseP-bd_barrel UniProtKB/TrEMBL
KEGG Report cfa:478593 UniProtKB/TrEMBL
NCBI Gene UMPS ENTREZGENE
Pfam OMPdecase UniProtKB/TrEMBL
  Pribosyltran UniProtKB/TrEMBL
PROSITE OMPDECASE UniProtKB/TrEMBL
SMART OMPdecase UniProtKB/TrEMBL
Superfamily-SCOP SSF51366 UniProtKB/TrEMBL
  SSF53271 UniProtKB/TrEMBL
TIGRFAMs pyrE UniProtKB/TrEMBL
  pyrF UniProtKB/TrEMBL
UniProt E2RRY7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48132 ENTREZGENE