SCGB1A1 (secretoglobin family 1A member 1) - Rat Genome Database

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Gene: SCGB1A1 (secretoglobin family 1A member 1) Canis lupus familiaris
Analyze
Symbol: SCGB1A1
Name: secretoglobin family 1A member 1 (Ensembl:asparaginase and isoaspartyl peptidase 1)
RGD ID: 12114148
Description: ENCODES a protein that exhibits polychlorinated biphenyl binding (ortholog); INVOLVED IN negative regulation of interleukin-13 production (ortholog); negative regulation of interleukin-4 production (ortholog); negative regulation of interleukin-5 production (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); allergic rhinitis (ortholog); FOUND IN extracellular space (ortholog); nuclear envelope (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: uteroglobin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,187,487 - 54,191,493 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,187,487 - 54,191,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,793,067 - 52,797,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,241,059 - 55,245,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,337,711 - 54,341,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,911,158 - 53,915,170 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,707,616 - 54,711,643 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCGB1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,187,487 - 54,191,493 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,187,487 - 54,191,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,793,067 - 52,797,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,241,059 - 55,245,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,337,711 - 54,341,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,911,158 - 53,915,170 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,707,616 - 54,711,643 (-)NCBIUU_Cfam_GSD_1.0
SCGB1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,419,033 - 62,423,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,405,103 - 62,423,195 (+)EnsemblGRCh38hg38GRCh38
GRCh371162,186,505 - 62,190,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,943,099 - 61,947,243 (+)NCBINCBI36Build 36hg18NCBI36
Build 341161,943,098 - 61,947,242NCBI
Celera1159,515,913 - 59,520,084 (+)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,514,572 - 58,518,782 (+)NCBIHuRef
CHM1_11162,069,549 - 62,073,720 (+)NCBICHM1_1
T2T-CHM13v2.01162,408,482 - 62,412,645 (+)NCBIT2T-CHM13v2.0
Scgb1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39199,061,006 - 9,065,320 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl199,061,000 - 9,065,322 (-)EnsemblGRCm39 Ensembl
GRCm38199,083,642 - 9,087,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl199,083,636 - 9,087,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv37199,158,132 - 9,162,446 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36199,150,685 - 9,154,970 (-)NCBIMGSCv36mm8
Celera198,844,116 - 8,848,457 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.05NCBI
Scgb1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,406,138 - 215,409,686 (-)NCBIGRCr8
mRatBN7.21205,977,060 - 205,980,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,977,060 - 205,980,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1214,394,838 - 214,398,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,420,410 - 221,423,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,109,801 - 214,113,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,279,698 - 225,283,246 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,279,676 - 225,283,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,216,740 - 232,220,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,758,103 - 211,761,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,916,532 - 211,920,081 (-)NCBI
Celera1203,487,454 - 203,490,852 (-)NCBICelera
Cytogenetic Map1q43NCBI
Scgb1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955599688,414 - 690,644 (-)NCBIChiLan1.0ChiLan1.0
SCGB1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,645,561 - 63,650,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,688,256 - 64,692,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,774,560 - 57,780,334 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,133,649 - 61,137,873 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,133,649 - 61,137,873 (+)Ensemblpanpan1.1panPan2
Scgb1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,684,916 - 10,687,790 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581798,739 - 801,633 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581798,738 - 801,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCGB1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,297,283 - 9,302,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.129,297,282 - 9,302,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,570,790 - 8,575,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCGB1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,470,091 - 11,474,915 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,470,195 - 11,474,149 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,816,965 - 108,820,794 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scgb1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249261,029,120 - 1,030,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SCGB1A1
93 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1 6
Medium 5 1 2 1 1
Low 3 11 6 6 1 1 3 2 2
Below cutoff 1 8 6 5 5 8 8 1 4

Sequence


RefSeq Acc Id: ENSCAFT00000025133   ⟹   ENSCAFP00000023330
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1854,187,487 - 54,191,482 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017377   ⟹   ENSCAFP00845013531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017460   ⟹   ENSCAFP00845013588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,241,059 - 55,245,064 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017474   ⟹   ENSCAFP00845013599
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,269,077 - 55,291,693 (-)Ensembl
RefSeq Acc Id: XM_005631626   ⟹   XP_005631683
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,187,487 - 54,191,493 (-)NCBI
Dog10K_Boxer_Tasha1852,793,067 - 52,797,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038425343   ⟹   XP_038281271
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01855,241,059 - 55,245,094 (-)NCBI
RefSeq Acc Id: XM_038501605   ⟹   XP_038357533
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11854,337,711 - 54,341,743 (-)NCBI
RefSeq Acc Id: XM_038564295   ⟹   XP_038420223
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01854,707,616 - 54,711,643 (-)NCBI
RefSeq Acc Id: XM_038628436   ⟹   XP_038484364
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01853,911,158 - 53,915,170 (-)NCBI
RefSeq Acc Id: XP_005631683   ⟸   XM_005631626
- UniProtKB: A0A0K2SR26 (UniProtKB/TrEMBL),   A0A8C0MBH7 (UniProtKB/TrEMBL),   E2R0A4 (UniProtKB/TrEMBL),   A0A8C0KG33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023330   ⟸   ENSCAFT00000025133
RefSeq Acc Id: XP_038357533   ⟸   XM_038501605
RefSeq Acc Id: XP_038484364   ⟸   XM_038628436
RefSeq Acc Id: XP_038281271   ⟸   XM_038425343
- UniProtKB: A0A0K2SR26 (UniProtKB/TrEMBL),   A0A8C0MBH7 (UniProtKB/TrEMBL),   E2R0A4 (UniProtKB/TrEMBL),   A0A8C0KG33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420223   ⟸   XM_038564295
- UniProtKB: A0A0K2SR26 (UniProtKB/TrEMBL),   A0A8C0KG33 (UniProtKB/TrEMBL),   A0A8C0MBH7 (UniProtKB/TrEMBL),   E2R0A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013599   ⟸   ENSCAFT00845017474
RefSeq Acc Id: ENSCAFP00845013531   ⟸   ENSCAFT00845017377
RefSeq Acc Id: ENSCAFP00845013588   ⟸   ENSCAFT00845017460

Promoters
RGD ID:13686658
Promoter ID:EPDNEW_C4726
Type:single initiation site
Name:SCGB1A1_1
Description:secretoglobin family 1A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,191,482 - 54,191,542EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015860 Ensembl
  ENSCAFG00000015868 UniProtKB/TrEMBL
  ENSCAFG00030004735 UniProtKB/TrEMBL
  ENSCAFG00040020641 UniProtKB/TrEMBL
  ENSCAFG00845009877 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025133.5 UniProtKB/TrEMBL
  ENSCAFT00030008699.1 UniProtKB/TrEMBL
  ENSCAFT00040038185.1 UniProtKB/TrEMBL
  ENSCAFT00845017377.1 UniProtKB/TrEMBL
  ENSCAFT00845017460 ENTREZGENE
  ENSCAFT00845017460.1 UniProtKB/TrEMBL
Gene3D-CATH Secretoglobin UniProtKB/TrEMBL
InterPro ASRGL1_meta UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/TrEMBL
  Peptidase_T2 UniProtKB/TrEMBL
  Secretoglobin UniProtKB/TrEMBL
  Secretoglobin_1C-like UniProtKB/TrEMBL
  Secretoglobin_sf UniProtKB/TrEMBL
  Uteroglobin UniProtKB/TrEMBL
KEGG Report cfa:476060 UniProtKB/TrEMBL
NCBI Gene SCGB1A1 ENTREZGENE
PANTHER ISOASPARTYL PEPTIDASE/L-ASPARAGINASE UniProtKB/TrEMBL
  PTHR10136 UniProtKB/TrEMBL
  PTHR10188 UniProtKB/TrEMBL
  UTEROGLOBIN UniProtKB/TrEMBL
Pfam Asparaginase_2 UniProtKB/TrEMBL
  Uteroglobin UniProtKB/TrEMBL
PRINTS UTEROGLOBIN UniProtKB/TrEMBL
PROSITE SCGB UniProtKB/TrEMBL
SMART UTG UniProtKB/TrEMBL
Superfamily-SCOP SSF48201 UniProtKB/TrEMBL
  SSF56235 UniProtKB/TrEMBL
UniProt A0A0K2SR26 ENTREZGENE
  A0A8C0KG33 ENTREZGENE
  A0A8C0MBH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2M1_CANLF UniProtKB/TrEMBL
  E2R0A4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0K2SR26 UniProtKB/TrEMBL
VGNC ID VGNC:45908 ENTREZGENE