IFIT5 (interferon induced protein with tetratricopeptide repeats 5) - Rat Genome Database

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Gene: IFIT5 (interferon induced protein with tetratricopeptide repeats 5) Canis lupus familiaris
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Symbol: IFIT5
Name: interferon induced protein with tetratricopeptide repeats 5
RGD ID: 12111756
Description: ENCODES a protein that exhibits double-stranded DNA binding (ortholog); poly(U) RNA binding (ortholog); RNA cap binding (ortholog); INVOLVED IN negative regulation of viral genome replication (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); Human Influenza (ortholog); Wolman disease (ortholog); FOUND IN actin cytoskeleton (ortholog); apical part of cell (ortholog); IkappaB kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interferon-induced protein with tetratricopeptide repeats 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,318,616 - 4,329,811 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,318,732 - 4,328,785 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,553,988 - 4,565,255 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,540,534 - 4,551,341 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1284,297,900 - 4,309,174 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0284,340,711 - 4,351,969 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,475,804 - 4,487,078 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IFIT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,318,616 - 4,329,811 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,318,732 - 4,328,785 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,553,988 - 4,565,255 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,540,534 - 4,551,341 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1284,297,900 - 4,309,174 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0284,340,711 - 4,351,969 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,475,804 - 4,487,078 (+)NCBIUU_Cfam_GSD_1.0
IFIT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,414,568 - 89,420,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,414,568 - 89,421,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371091,174,325 - 91,180,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361091,164,419 - 91,170,733 (+)NCBINCBI36Build 36hg18NCBI36
Build 341091,164,418 - 91,170,733NCBI
Celera1084,921,138 - 84,927,568 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,808,501 - 84,814,936 (+)NCBIHuRef
CHM1_11091,456,350 - 91,462,775 (+)NCBICHM1_1
T2T-CHM13v2.01090,298,411 - 90,304,831 (+)NCBIT2T-CHM13v2.0
Or5an1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391912,257,218 - 12,261,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1912,257,218 - 12,262,990 (+)EnsemblGRCm39 Ensembl
GRCm381912,279,854 - 12,283,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1912,279,854 - 12,285,626 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,357,540 - 12,358,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,350,095 - 12,351,033 (+)NCBIMGSCv36mm8
Celera1912,957,098 - 12,958,036 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.71NCBI
Ifit5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554253,569,448 - 3,575,043 (-)NCBIChiLan1.0ChiLan1.0
IFIT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,432,724 - 101,438,778 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,438,136 - 101,444,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01086,139,816 - 86,146,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,678,683 - 89,685,839 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,678,703 - 89,685,839 (+)Ensemblpanpan1.1panPan2
Ifit5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,150,581 - 43,159,288 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366014,783,150 - 4,791,918 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366014,785,837 - 4,791,893 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFIT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,263,445 - 101,267,067 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,254,818 - 101,266,105 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,240,722 - 110,253,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IFIT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,801,437 - 82,806,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,800,825 - 82,805,599 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604843,476,039 - 43,483,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifit5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624737297,012 - 303,449 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IFIT5
140 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 18 4 4 4 6 1 4 8 10 6
Low 1 5 4 2 2 2 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011462   ⟹   ENSCAFP00000010620
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,319,100 - 4,328,223 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000091651   ⟹   ENSCAFP00000064785
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,318,732 - 4,328,785 (+)Ensembl
RefSeq Acc Id: XM_005637512   ⟹   XP_005637569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,318,633 - 4,329,811 (+)NCBI
Dog10K_Boxer_Tasha284,554,051 - 4,565,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005637513   ⟹   XP_005637570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,318,616 - 4,329,806 (+)NCBI
Dog10K_Boxer_Tasha284,553,988 - 4,565,255 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038439884   ⟹   XP_038295812
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0284,540,597 - 4,551,341 (+)NCBI
RefSeq Acc Id: XM_038439885   ⟹   XP_038295813
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0284,540,534 - 4,551,341 (+)NCBI
RefSeq Acc Id: XM_038514502   ⟹   XP_038370430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1284,297,963 - 4,309,174 (+)NCBI
RefSeq Acc Id: XM_038514503   ⟹   XP_038370431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1284,297,900 - 4,309,174 (+)NCBI
RefSeq Acc Id: XM_038578149   ⟹   XP_038434077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0284,475,867 - 4,487,078 (+)NCBI
RefSeq Acc Id: XM_038578150   ⟹   XP_038434078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0284,475,804 - 4,487,078 (+)NCBI
RefSeq Acc Id: XM_038642315   ⟹   XP_038498243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0284,340,774 - 4,351,969 (+)NCBI
RefSeq Acc Id: XM_038642316   ⟹   XP_038498244
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0284,340,711 - 4,351,969 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005637569   ⟸   XM_005637512
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NTM9 (UniProtKB/TrEMBL),   A0A8P0N9N1 (UniProtKB/TrEMBL),   A0A8C0TZD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005637570   ⟸   XM_005637513
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RN20 (UniProtKB/TrEMBL),   A0A8P0PDG8 (UniProtKB/TrEMBL),   A0A8C0TZD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010620   ⟸   ENSCAFT00000011462
RefSeq Acc Id: ENSCAFP00000064785   ⟸   ENSCAFT00000091651
RefSeq Acc Id: XP_038370431   ⟸   XM_038514503
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038370430   ⟸   XM_038514502
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038498244   ⟸   XM_038642316
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038498243   ⟸   XM_038642315
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038295813   ⟸   XM_038439885
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R7P7 (UniProtKB/TrEMBL),   A0A8C0TY39 (UniProtKB/TrEMBL),   A0A8I3S6P3 (UniProtKB/TrEMBL),   A0A8C0TZD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295812   ⟸   XM_038439884
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHN7 (UniProtKB/TrEMBL),   A0A8C0TY00 (UniProtKB/TrEMBL),   A0A8I3Q503 (UniProtKB/TrEMBL),   A0A8C0TZD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434078   ⟸   XM_038578150
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RN20 (UniProtKB/TrEMBL),   A0A8C0TZD0 (UniProtKB/TrEMBL),   A0A8P0PDG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434077   ⟸   XM_038578149
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NTM9 (UniProtKB/TrEMBL),   A0A8C0TZD0 (UniProtKB/TrEMBL),   A0A8P0N9N1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007151 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018402 UniProtKB/TrEMBL
  ENSCAFG00040025750 UniProtKB/TrEMBL
  ENSCAFG00845028375 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011462.5 UniProtKB/TrEMBL
  ENSCAFT00000091651.2 UniProtKB/TrEMBL
  ENSCAFT00030033864.1 UniProtKB/TrEMBL
  ENSCAFT00030033889.1 UniProtKB/TrEMBL
  ENSCAFT00040048085.1 UniProtKB/TrEMBL
  ENSCAFT00040048087.1 UniProtKB/TrEMBL
  ENSCAFT00040048089.1 UniProtKB/TrEMBL
  ENSCAFT00845050060 ENTREZGENE
  ENSCAFT00845050060.1 UniProtKB/TrEMBL
  ENSCAFT00845050076 ENTREZGENE
  ENSCAFT00845050076.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_2 UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report cfa:486788 UniProtKB/TrEMBL
NCBI Gene IFIT5 ENTREZGENE
PANTHER INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS UniProtKB/TrEMBL
  PTHR10271:SF28 UniProtKB/TrEMBL
Pfam TPR_12 UniProtKB/TrEMBL
  TPR_2 UniProtKB/TrEMBL
  TPR_7 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PROSITE TPR UniProtKB/TrEMBL
  TPR_REGION UniProtKB/TrEMBL
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A8C0LHN7 ENTREZGENE
  A0A8C0NTM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R7P7 ENTREZGENE
  A0A8C0RN20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TY00 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TY39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TZD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q503 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S6P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N9N1 ENTREZGENE
  A0A8P0PDG8 ENTREZGENE
UniProt Secondary A0A8P0N9N1 UniProtKB/TrEMBL
  A0A8P0PDG8 UniProtKB/TrEMBL
VGNC ID VGNC:97201 ENTREZGENE