DCXR (dicarbonyl and L-xylulose reductase)

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Gene: DCXR (dicarbonyl and L-xylulose reductase) Canis lupus familiaris

Analyze

Symbol:

DCXR

Name:

dicarbonyl and L-xylulose reductase

RGD ID:

12109905

Description:

ENCODES a protein that exhibits identical protein binding (inferred); L-xylulose reductase (NADP+) activity (inferred); oxidoreductase activity (inferred); INVOLVED IN NADP metabolic process (ortholog); xylulose metabolic process (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); obesity (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

L-xylulose reductase

RGD Orthologs

Human

Mouse

Rat

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	289,864 - 291,518 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	289,889 - 291,480 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	891,671 - 893,706 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	882,891 - 884,926 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	882,938 - 884,888 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	908,059 - 910,094 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,034,747 - 1,036,782 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,113,334 - 1,115,369 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

obesity (ISO)

pentosuria (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glucose metabolic process (IEA)

glucuronate catabolic process to xylulose 5-phosphate (IEA)

NADP metabolic process (IEA,ISO)

positive regulation of reactive oxygen species metabolic process (IEA)

xylulose metabolic process (IEA,ISO)

Cellular Component

brush border (IEA)

cytoplasmic microtubule (IEA)

cytosol (IEA,ISO)

microvillus (IEA)

Molecular Function

identical protein binding (IEA)

L-xylulose reductase (NADP+) activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on CH-OH group of donors (IEA)

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

References

Genomics

Comparative Map Data

DCXR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	289,864 - 291,518 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	289,889 - 291,480 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	891,671 - 893,706 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	882,891 - 884,926 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	882,938 - 884,888 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	908,059 - 910,094 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,034,747 - 1,036,782 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,113,334 - 1,115,369 (+)	NCBI		UU_Cfam_GSD_1.0

DCXR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	82,035,858 - 82,037,697 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	82,035,136 - 82,037,709 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	79,993,734 - 79,995,573 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,587,046 - 77,588,862 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	77,587,045 - 77,588,862	NCBI
Celera	17	76,587,448 - 76,589,264 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,393,877 - 75,395,693 (-)	NCBI		HuRef
CHM1_1	17	80,079,960 - 80,081,776 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,903,016 - 82,904,855 (-)	NCBI		T2T-CHM13v2.0

Dcxr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,615,372 - 120,618,110 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,616,225 - 120,618,107 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,724,546 - 120,727,284 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,725,399 - 120,727,281 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,586,687 - 120,588,595 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,541,491 - 120,543,370 (-)	NCBI		MGSCv36	mm8
Celera	11	132,460,832 - 132,462,740 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI

Dcxr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	106,006,404 - 106,008,294 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	10	111,110,399 - 111,112,288 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,573,434 - 110,575,323 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	105,926,854 - 105,928,743 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	109,906,119 - 109,909,696 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,906,815 - 109,909,715 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,499,388 - 109,501,278 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	104,550,346 - 104,552,236 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

DCXR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	82,145,224 - 82,147,257 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,145,224 - 82,147,257 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	17	76,439,645 - 76,442,282 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LOC101967786
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	877,786 - 879,695 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,531,560 - 5,538,105 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936594	5,532,264 - 5,534,129 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CBR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	973,760 - 976,017 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	973,780 - 976,017 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DCXR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,923,170 - 73,925,025 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,919,463 - 73,925,277 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,390,184 - 45,392,044 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dcxr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,865,219 - 10,868,060 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,866,264 - 10,868,064 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in DCXR
44 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High											5
Medium	5	5	22	6	6	6	6	6	12	7	5	6
Low										1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014116228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038484633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038546275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038610282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038623119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038675393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000009576 ⟹ ENSCAFP00000008891

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	289,889 - 291,480 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845014330 ⟹ ENSCAFP00845011100

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	882,938 - 884,888 (+)	Ensembl

RefSeq Acc Id:

XM_038484633 ⟹ XP_038340561

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	9	908,059 - 910,094 (+)	NCBI

RefSeq Acc Id:

XM_038546275 ⟹ XP_038402203

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	9	1,113,334 - 1,115,369 (+)	NCBI

RefSeq Acc Id:

XM_038610282 ⟹ XP_038466210

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	9	1,034,747 - 1,036,782 (+)	NCBI

RefSeq Acc Id:

XM_038623119 ⟹ XP_038479047

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	9	891,671 - 893,706 (+)	NCBI

RefSeq Acc Id:

XM_038675393 ⟹ XP_038531321

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	882,891 - 884,926 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038340561	(Get FASTA)	NCBI Sequence Viewer
	XP_038402203	(Get FASTA)	NCBI Sequence Viewer
	XP_038466210	(Get FASTA)	NCBI Sequence Viewer
	XP_038479047	(Get FASTA)	NCBI Sequence Viewer
	XP_038531321	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSCAFP00000008891 ⟸ ENSCAFT00000009576

RefSeq Acc Id:

XP_038340561 ⟸ XM_038484633

RefSeq Acc Id:

XP_038466210 ⟸ XM_038610282

RefSeq Acc Id:	XP_038531321 ⟸ XM_038675393
- UniProtKB:	A0A8C0NLD8 (UniProtKB/TrEMBL), A0A8C0KBR1 (UniProtKB/TrEMBL), A0A8I3N7Q9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038479047 ⟸ XM_038623119
- UniProtKB:	A0A8C0NLD8 (UniProtKB/TrEMBL), A0A8C0KBR1 (UniProtKB/TrEMBL), A0A8I3N7Q9 (UniProtKB/TrEMBL)

RefSeq Acc Id:

XP_038402203 ⟸ XM_038546275

RefSeq Acc Id:

ENSCAFP00845011100 ⟸ ENSCAFT00845014330

Promoters

RGD ID:

13684377

Promoter ID:

EPDNEW_C2444

Type:

single initiation site

Name:

DCXR_1

Description:

dicarbonyl and L-xylulose reductase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	284,704 - 284,764	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000005927	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030017992	UniProtKB/TrEMBL
	ENSCAFG00040006800	UniProtKB/TrEMBL
	ENSCAFG00845008136	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00000008891.5	UniProtKB/TrEMBL
	ENSCAFP00030028934.1	UniProtKB/TrEMBL
	ENSCAFP00040010958	UniProtKB/TrEMBL
	ENSCAFP00845011100	ENTREZGENE
	ENSCAFP00845011100.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000009576.6	UniProtKB/TrEMBL
	ENSCAFT00030033168.1	UniProtKB/TrEMBL
	ENSCAFT00040012643	UniProtKB/TrEMBL
	ENSCAFT00845014330	ENTREZGENE
	ENSCAFT00845014330.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	DCXR	ENTREZGENE
PANTHER	D-ERYTHRULOSE REDUCTASE	UniProtKB/TrEMBL
	L-XYLULOSE REDUCTASE	UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8C0KBR1	ENTREZGENE
	A0A8C0NLD8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N7Q9	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:39825	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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