SLC22A1 (solute carrier family 22 member 1) - Rat Genome Database

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Gene: SLC22A1 (solute carrier family 22 member 1) Canis lupus familiaris
Analyze
Symbol: SLC22A1
Name: solute carrier family 22 member 1
RGD ID: 12106549
Description: ENCODES a protein that exhibits acetylcholine transmembrane transporter activity (ortholog); dopamine:sodium symporter activity (ortholog); identical protein binding (ortholog); INVOLVED IN dopamine transport (ortholog); epinephrine transport (ortholog); establishment or maintenance of transmembrane electrochemical gradient (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; tramadol pharmacokinetics pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); acute kidney failure (ortholog); asthma (ortholog); FOUND IN basolateral plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,268,978 - 49,296,522 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,109,085 - 50,138,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,451,887 - 49,481,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,451,182 - 49,482,182 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,334,247 - 49,363,803 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,205,883 - 49,235,453 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,820,796 - 49,850,348 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC22A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,268,978 - 49,296,522 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,109,085 - 50,138,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,451,887 - 49,481,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,451,182 - 49,482,182 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,334,247 - 49,363,803 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,205,883 - 49,235,453 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,820,796 - 49,850,348 (+)NCBIUU_Cfam_GSD_1.0
SLC22A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,121,815 - 160,158,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,121,815 - 160,158,718 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,542,847 - 160,579,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,462,853 - 160,499,740 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,513,273 - 160,550,159NCBI
Celera6161,188,634 - 161,224,539 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,013,550 - 158,049,540 (+)NCBIHuRef
CHM1_16160,805,108 - 160,841,995 (+)NCBICHM1_1
T2T-CHM13v2.06161,367,910 - 161,404,908 (+)NCBIT2T-CHM13v2.0
Slc22a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,867,761 - 12,894,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,867,756 - 12,894,716 (-)EnsemblGRCm39 Ensembl
GRCm381712,648,874 - 12,675,838 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,648,869 - 12,675,829 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,841,740 - 12,868,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,492,232 - 12,519,196 (-)NCBIMGSCv36mm8
Celera1712,680,587 - 12,707,864 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.63NCBI
Slc22a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,624,339 - 50,651,437 (+)NCBIGRCr8
mRatBN7.2148,076,657 - 48,103,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,076,666 - 48,103,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,768,287 - 48,795,288 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,754,091 - 54,781,071 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,843,810 - 48,870,799 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,273,639 - 48,300,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,273,611 - 48,300,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,452,604 - 51,479,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,351,239 - 42,378,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,354,183 - 42,381,239 (+)NCBI
Celera143,876,335 - 43,903,290 (+)NCBICelera
Cytogenetic Map1q11NCBI
SLC22A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,216,337 - 180,263,051 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,125,295 - 178,169,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,004,545 - 158,046,428 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,014,522 - 163,054,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,014,663 - 163,054,681 (+)Ensemblpanpan1.1panPan2
Slc22a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,281,749 - 144,305,075 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,534,095 - 11,556,745 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,534,095 - 11,556,759 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,340,126 - 7,365,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,340,442 - 7,365,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,139,435 - 9,164,369 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,744,600 - 87,780,846 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,745,023 - 87,781,073 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,132,123 - 60,167,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in SLC22A1
544 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845003731   ⟹   ENSCAFP00845002964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl149,451,182 - 49,482,182 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845003747   ⟹   ENSCAFP00845002976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl149,451,182 - 49,480,807 (+)Ensembl
RefSeq Acc Id: XM_038465820   ⟹   XP_038321748
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1149,334,247 - 49,363,803 (+)NCBI
RefSeq Acc Id: XM_038526495   ⟹   XP_038382423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0149,820,796 - 49,850,348 (+)NCBI
RefSeq Acc Id: XM_038528819   ⟹   XP_038384747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha150,109,085 - 50,138,635 (+)NCBI
RefSeq Acc Id: XM_038590786   ⟹   XP_038446714
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0149,205,883 - 49,235,453 (+)NCBI
RefSeq Acc Id: XM_038654581   ⟹   XP_038510509
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0149,451,887 - 49,481,466 (+)NCBI
RefSeq Acc Id: XP_038321748   ⟸   XM_038465820
RefSeq Acc Id: XP_038446714   ⟸   XM_038590786
RefSeq Acc Id: XP_038510509   ⟸   XM_038654581
- UniProtKB: A0A8C0Q0N3 (UniProtKB/TrEMBL),   A0A8I3MM56 (UniProtKB/TrEMBL),   A0A8C0RIN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384747   ⟸   XM_038528819
- UniProtKB: A0A8C0Q0N3 (UniProtKB/TrEMBL),   A0A8I3MM56 (UniProtKB/TrEMBL),   A0A8C0RIN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038382423   ⟸   XM_038526495
- UniProtKB: A0A8C0RIN7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845002964   ⟸   ENSCAFT00845003731
Ensembl Acc Id: ENSCAFP00845002976   ⟸   ENSCAFT00845003747
Protein Domains
Major facilitator superfamily (MFS) profile

Promoters
RGD ID:13682021
Promoter ID:EPDNEW_C89
Type:initiation region
Name:SLC22A1_1
Description:solute carrier family 22 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1149,269,176 - 49,269,236EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000052244 UniProtKB/TrEMBL
  ENSCAFG00030012393 UniProtKB/TrEMBL
  ENSCAFG00040000103 UniProtKB/TrEMBL
  ENSCAFG00845002132 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000098691.1 UniProtKB/TrEMBL
  ENSCAFT00000103654.1 UniProtKB/TrEMBL
  ENSCAFT00030023165.1 UniProtKB/TrEMBL
  ENSCAFT00040000171.1 UniProtKB/TrEMBL
  ENSCAFT00040000188.1 UniProtKB/TrEMBL
  ENSCAFT00845003731 ENTREZGENE
  ENSCAFT00845003731.1 UniProtKB/TrEMBL
  ENSCAFT00845003747.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
NCBI Gene SLC22A1 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 1 UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A8C0PT91_CANLF UniProtKB/TrEMBL
  A0A8C0Q0N3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RIN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MM56 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MM63_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46270 ENTREZGENE