NGFR (nerve growth factor receptor) - Rat Genome Database

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Gene: NGFR (nerve growth factor receptor) Canis lupus familiaris
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Symbol: NGFR
Name: nerve growth factor receptor
RGD ID: 12105974
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); identical protein binding (ortholog); nerve growth factor binding (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to oxidative stress (ortholog); central nervous system development (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); Alcohol-Related Disorders (ortholog); Alzheimer's disease (ortholog); FOUND IN clathrin-coated endocytic vesicle (ortholog); dendrite membrane (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,598,468 - 25,621,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,601,074 - 25,623,274 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,057,204 - 25,079,762 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,393,929 - 26,416,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,396,704 - 26,416,363 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,161,801 - 25,184,255 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,420,950 - 25,443,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,550,245 - 25,572,703 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
axon guidance  (IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to oxidative stress  (ISO)
central nervous system development  (IEA,ISO)
circadian regulation of gene expression  (IEA)
circadian rhythm  (IEA)
detection of temperature stimulus  (IEA,ISO)
dorsal aorta development  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glucose homeostasis  (IEA)
hair follicle development  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
intracellular glucose homeostasis  (IEA)
intracellular protein transport  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of dendritic spine development  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of hair follicle development  (IEA,ISO)
negative regulation of mitochondrial depolarization  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron projection development  (ISO)
nerve development  (IEA,ISO)
neuron apoptotic process  (IEA)
odontogenesis of dentin-containing tooth  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cellular process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of myelination  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to nucleus  (IEA)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
presynaptic modulation of chemical synaptic transmission  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of response to biotic stimulus  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
Rho protein signal transduction  (IEA)
signal transduction  (IEA)
skeletal muscle cell differentiation  (ISO)
skin development  (IEA,ISO)

References
Additional References at PubMed
PMID:23637462   PMID:30032202  


Genomics

Comparative Map Data
NGFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,598,468 - 25,621,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,601,074 - 25,623,274 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,057,204 - 25,079,762 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,393,929 - 26,416,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,396,704 - 26,416,363 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,161,801 - 25,184,255 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,420,950 - 25,443,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,550,245 - 25,572,703 (+)NCBIUU_Cfam_GSD_1.0
NGFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,495,293 - 49,515,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,495,293 - 49,515,008 (+)EnsemblGRCh38hg38GRCh38
GRCh371747,572,655 - 47,592,370 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,927,666 - 44,947,360 (+)NCBINCBI36Build 36hg18NCBI36
Build 341744,927,665 - 44,947,360NCBI
Celera1744,027,660 - 44,047,391 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1742,937,638 - 42,957,366 (+)NCBIHuRef
CHM1_11747,637,800 - 47,657,550 (+)NCBICHM1_1
T2T-CHM13v2.01750,358,300 - 50,378,028 (+)NCBIT2T-CHM13v2.0
Ngfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,459,644 - 95,478,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,459,644 - 95,478,561 (-)EnsemblGRCm39 Ensembl
GRCm381195,568,818 - 95,587,698 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,568,818 - 95,587,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,430,132 - 95,449,012 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,384,908 - 95,403,788 (-)NCBIMGSCv36mm8
Celera11105,207,524 - 105,226,387 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Ngfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,012,077 - 81,030,305 (-)NCBIGRCr8
mRatBN7.21080,515,287 - 80,533,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,515,299 - 80,533,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,464,096 - 85,482,268 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,962,134 - 84,980,305 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,354,313 - 80,372,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,389,828 - 83,408,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,389,847 - 83,408,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,198,396 - 83,216,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,262,804 - 84,281,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,277,173 - 84,295,376 (-)NCBI
Celera1079,287,338 - 79,305,497 (-)NCBICelera
Cytogenetic Map10q26NCBI
Ngfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,030,252 - 12,047,305 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,030,303 - 12,047,305 (-)NCBIChiLan1.0ChiLan1.0
NGFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,652,673 - 15,672,433 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,618,638 - 17,638,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,089,600 - 8,109,361 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,075,301 - 8,094,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,075,316 - 8,094,966 (-)Ensemblpanpan1.1panPan2
Ngfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,017,882 - 25,037,009 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,035,769 - 12,057,263 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,038,500 - 12,057,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,699,427 - 25,720,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,699,410 - 25,720,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,702,140 - 25,722,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,894,000 - 69,914,209 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,894,139 - 69,912,189 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,998,497 - 41,018,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ngfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,623,700 - 5,639,655 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,623,686 - 5,639,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NGFR
200 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 6 5 1
Low 5 5 17 1 1 6 3 10 6 5
Below cutoff 3 2 8 4

Sequence


RefSeq Acc Id: ENSCAFT00000049876   ⟹   ENSCAFP00000042847
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl925,601,074 - 25,623,274 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019806   ⟹   ENSCAFP00845015506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl926,396,704 - 26,416,363 (+)Ensembl
RefSeq Acc Id: XM_038484511   ⟹   XP_038340439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1925,161,801 - 25,184,255 (+)NCBI
RefSeq Acc Id: XM_038546030   ⟹   XP_038401958
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0925,550,245 - 25,572,703 (+)NCBI
RefSeq Acc Id: XM_038610058   ⟹   XP_038465986
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0925,420,950 - 25,443,499 (+)NCBI
RefSeq Acc Id: XM_038619094   ⟹   XP_038475022
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha925,057,204 - 25,079,762 (+)NCBI
RefSeq Acc Id: XM_038675121   ⟹   XP_038531049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0926,393,929 - 26,416,386 (+)NCBI
RefSeq Acc Id: ENSCAFP00000042847   ⟸   ENSCAFT00000049876
RefSeq Acc Id: XP_038340439   ⟸   XM_038484511
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038465986   ⟸   XM_038610058
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038531049   ⟸   XM_038675121
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S459 (UniProtKB/TrEMBL),   A0A8I3NE38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038475022   ⟸   XM_038619094
- Peptide Label: isoform X3
- UniProtKB: A0A8C0S459 (UniProtKB/TrEMBL),   A0A8I3NE38 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401958   ⟸   XM_038546030
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S459 (UniProtKB/TrEMBL),   A0A8I3NE38 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845015506   ⟸   ENSCAFT00845019806
Protein Domains
Death   TNFR-Cys


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016934 Ensembl
  ENSCAFG00000053983 UniProtKB/TrEMBL
  ENSCAFG00030001362 UniProtKB/TrEMBL
  ENSCAFG00040009629 UniProtKB/TrEMBL
  ENSCAFG00845011173 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000096793.1 UniProtKB/TrEMBL
  ENSCAFT00030002414.1 UniProtKB/TrEMBL
  ENSCAFT00040017913.1 UniProtKB/TrEMBL
  ENSCAFT00845019806 ENTREZGENE
  ENSCAFT00845019806.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  6.10.250.1780 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFR16_TM UniProtKB/TrEMBL
  TNFR_16 UniProtKB/TrEMBL
  TNFRSF16_N UniProtKB/TrEMBL
NCBI Gene NGFR ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR RECEPTOR UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  TNFR_16_TM UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/TrEMBL
PRINTS TNFACTORR16 UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  TNFR_NGFR_1 UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  TNFR UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  TNF receptor-like UniProtKB/TrEMBL
UniProt A0A8C0S459 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NE38 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:55650 ENTREZGENE