TESK1 (testis associated actin remodelling kinase 1) - Rat Genome Database

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Gene: TESK1 (testis associated actin remodelling kinase 1) Canis lupus familiaris
Analyze
Symbol: TESK1
Name: testis associated actin remodelling kinase 1
RGD ID: 12104324
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN negative regulation of protein autophosphorylation (ortholog); regulation of protein localization (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytoplasmic vesicle (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity testis-specific protein kinase 1; testis-specific kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,166,049 - 52,170,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,166,276 - 52,170,309 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,734,356 - 50,738,706 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,231,692 - 53,236,046 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,231,707 - 53,235,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,776,354 - 51,780,701 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,759,750 - 51,764,109 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,461,910 - 52,466,261 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TESK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,166,049 - 52,170,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,166,276 - 52,170,309 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,734,356 - 50,738,706 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,231,692 - 53,236,046 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,231,707 - 53,235,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,776,354 - 51,780,701 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,759,750 - 51,764,109 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,461,910 - 52,466,261 (+)NCBIUU_Cfam_GSD_1.0
TESK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,605,262 - 35,610,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,605,262 - 35,610,041 (+)EnsemblGRCh38hg38GRCh38
GRCh37935,605,259 - 35,610,030 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,595,281 - 35,600,038 (+)NCBINCBI36Build 36hg18NCBI36
Build 34935,595,366 - 35,600,029NCBI
Celera935,538,842 - 35,543,599 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,561,511 - 35,565,732 (+)NCBIHuRef
CHM1_1935,605,086 - 35,609,864 (+)NCBICHM1_1
T2T-CHM13v2.0935,625,926 - 35,630,697 (+)NCBIT2T-CHM13v2.0
Tesk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,442,277 - 43,448,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,441,939 - 43,448,064 (+)EnsemblGRCm39 Ensembl
GRCm38443,442,277 - 43,448,075 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,441,939 - 43,448,064 (+)EnsemblGRCm38mm10GRCm38
MGSCv37443,455,149 - 43,460,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,463,039 - 43,469,161 (+)NCBIMGSCv36mm8
Celera443,475,911 - 43,481,710 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.04NCBI
Tesk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,487,763 - 62,493,492 (+)NCBIGRCr8
mRatBN7.2557,691,922 - 57,697,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,691,969 - 57,697,698 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,671,582 - 59,677,308 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,490,395 - 61,496,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,467,194 - 61,472,918 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,937,615 - 58,943,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,937,615 - 58,943,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,463,575 - 63,469,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,913,793 - 59,918,422 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,913,971 - 59,918,601 (+)NCBI
Celera556,273,675 - 56,279,404 (+)NCBICelera
Cytogenetic Map5q22NCBI
Tesk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472668,352 - 699,620 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955472670,847 - 676,060 (-)NCBIChiLan1.0ChiLan1.0
TESK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,977,614 - 88,982,391 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,983,553 - 88,988,330 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,456,965 - 35,461,736 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,260,165 - 36,264,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,258,902 - 36,264,545 (+)Ensemblpanpan1.1panPan2
Tesk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,068,349 - 167,072,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,615,927 - 3,621,474 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,615,933 - 3,620,384 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TESK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,341,261 - 236,345,962 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,341,160 - 236,345,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,064,388 - 264,070,983 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TESK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,985,770 - 44,990,520 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,984,687 - 44,990,183 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,094,178 - 42,100,748 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tesk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,198,984 - 5,204,019 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,198,276 - 5,203,376 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TESK1
40 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 16 6 6 1 12 8 10 6
Low 1 6 6 6 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003265   ⟹   ENSCAFP00000003034
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1152,166,276 - 52,170,309 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845014581   ⟹   ENSCAFP00845011298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1153,231,707 - 53,235,744 (+)Ensembl
RefSeq Acc Id: XM_038490617   ⟹   XP_038346545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11151,776,354 - 51,780,701 (+)NCBI
RefSeq Acc Id: XM_038552743   ⟹   XP_038408671
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01152,461,910 - 52,466,261 (+)NCBI
RefSeq Acc Id: XM_038616604   ⟹   XP_038472532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01151,759,750 - 51,764,109 (+)NCBI
RefSeq Acc Id: XM_038664031   ⟹   XP_038519959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1150,734,356 - 50,738,706 (+)NCBI
RefSeq Acc Id: XM_038682071   ⟹   XP_038537999
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01153,231,692 - 53,236,046 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000003034   ⟸   ENSCAFT00000003265
RefSeq Acc Id: XP_038346545   ⟸   XM_038490617
RefSeq Acc Id: XP_038472532   ⟸   XM_038616604
RefSeq Acc Id: XP_038537999   ⟸   XM_038682071
- UniProtKB: A0A8I3N4D5 (UniProtKB/TrEMBL),   A0A8P0N563 (UniProtKB/TrEMBL),   A0A8C0NAQ2 (UniProtKB/TrEMBL),   A0A8C0SBE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038519959   ⟸   XM_038664031
- UniProtKB: A0A8I3N4D5 (UniProtKB/TrEMBL),   A0A8P0N563 (UniProtKB/TrEMBL),   A0A8C0NAQ2 (UniProtKB/TrEMBL),   A0A8C0SBE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038408671   ⟸   XM_038552743
- UniProtKB: A0A8C0NAQ2 (UniProtKB/TrEMBL),   A0A8C0SBE0 (UniProtKB/TrEMBL),   A0A8I3N4D5 (UniProtKB/TrEMBL),   A0A8P0N563 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011298   ⟸   ENSCAFT00845014581
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002058 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011224 UniProtKB/TrEMBL
  ENSCAFG00040011469 UniProtKB/TrEMBL
  ENSCAFG00845008265 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003265.6 UniProtKB/TrEMBL
  ENSCAFT00030020851.1 UniProtKB/TrEMBL
  ENSCAFT00040021252.1 UniProtKB/TrEMBL
  ENSCAFT00845014581 ENTREZGENE
  ENSCAFT00845014581.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
NCBI Gene TESK1 ENTREZGENE
PANTHER LIM DOMAIN KINASE 1 UniProtKB/TrEMBL
  PTHR46485:SF3 UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0NAQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SBE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N4D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N563 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:56071 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-13 TESK1  testis associated actin remodelling kinase 1    testis-specific kinase 1  Symbol and/or name change 5135510 APPROVED