DLA-DOA (HLA class II histocompatibility antigen, DO alpha chain-like) - Rat Genome Database

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Gene: DLA-DOA (HLA class II histocompatibility antigen, DO alpha chain-like) Canis lupus familiaris
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Symbol: DLA-DOA
Name: HLA class II histocompatibility antigen, DO alpha chain-like
RGD ID: 12103713
Description: ENCODES a protein that exhibits MHC class II protein complex binding (inferred); INVOLVED IN antigen processing and presentation (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); regulation of T cell differentiation (ortholog); ASSOCIATED WITH Familial Prostate Cancer (ortholog); liver disease (ortholog); occupational asthma (ortholog); FOUND IN collagen trimer (inferred); membrane (inferred); MHC class II protein complex (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MHC class II antigen DO alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,563,673 - 2,568,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,563,673 - 2,568,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,645,022 - 2,649,677 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,894,424 - 2,899,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,894,424 - 2,899,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,562,685 - 2,567,336 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,644,035 - 2,648,683 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,718,589 - 2,723,244 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:15607421   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DLA-DOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,563,673 - 2,568,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,563,673 - 2,568,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,645,022 - 2,649,677 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,894,424 - 2,899,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,894,424 - 2,899,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,562,685 - 2,567,336 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,644,035 - 2,648,683 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,718,589 - 2,723,244 (-)NCBIUU_Cfam_GSD_1.0
HLA-DOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,004,182 - 33,009,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,004,182 - 33,009,591 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,971,959 - 32,977,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,079,937 - 33,085,367 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,081,330 - 33,085,315NCBI
Celera634,520,840 - 34,526,270 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,714,467 - 32,719,897 (-)NCBIHuRef
CHM1_1632,972,734 - 32,978,164 (-)NCBICHM1_1
T2T-CHM13v2.0632,825,532 - 32,830,941 (-)NCBIT2T-CHM13v2.0
H2-Oa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,311,353 - 34,314,286 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,311,314 - 34,314,208 (+)EnsemblGRCm39 Ensembl
GRCm381734,092,379 - 34,095,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,092,340 - 34,095,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,229,324 - 34,232,179 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,702,886 - 33,705,688 (+)NCBIMGSCv36mm8
Celera1736,839,367 - 36,842,221 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
RT1-DOa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,755,287 - 4,758,491 (-)NCBIGRCr8
mRatBN7.2204,753,587 - 4,756,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,753,598 - 4,756,577 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,506,215 - 5,508,610 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,867,962 - 4,870,357 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,349,348 - 5,351,873 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,889,106 - 3,892,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,889,370 - 3,892,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,968,563 - 5,971,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,890,410 - 4,894,048 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,890,638 - 4,894,271 (-)NCBI
Celera206,354,703 - 6,357,121 (-)NCBICelera
Cytogenetic Map20p12NCBI
LOC102025166
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,603,168 - 1,607,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,603,395 - 1,606,800 (-)NCBIChiLan1.0ChiLan1.0
LOC100967723
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,479,615 - 47,485,045 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,351,225 - 43,356,655 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,573,975 - 32,579,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,689,171 - 33,694,590 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,689,171 - 33,694,576 (-)Ensemblpanpan1.1panPan2
LOC101963482
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,169,344 - 38,173,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,787,492 - 25,790,950 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,786,322 - 25,790,881 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLA-DOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,178,884 - 25,182,707 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,178,866 - 25,182,665 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,545,479 - 29,549,278 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MHC-DOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,084,785 - 39,090,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,085,080 - 39,090,474 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,794,062 - 32,799,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101698840
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,725,986 - 23,727,765 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,725,903 - 23,729,446 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DLA-DOA
59 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2
Low 3 11 1 4 1 6 9
Below cutoff 2 5 11 5 5 6 6 6 8 1 6

Sequence


RefSeq Acc Id: ENSCAFT00000001394   ⟹   ENSCAFP00000001280
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl122,563,673 - 2,568,328 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033413   ⟹   ENSCAFP00845026158
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl122,894,424 - 2,899,075 (-)Ensembl
RefSeq Acc Id: NM_001313787   ⟹   NP_001300716
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1122,563,673 - 2,568,328 (-)NCBI
Dog10K_Boxer_Tasha122,645,022 - 2,649,677 (-)NCBI
ROS_Cfam_1.0122,894,424 - 2,899,075 (-)NCBI
UMICH_Zoey_3.1122,562,685 - 2,567,336 (-)NCBI
UNSW_CanFamBas_1.0122,644,035 - 2,648,683 (-)NCBI
UU_Cfam_GSD_1.0122,718,589 - 2,723,244 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001300716 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAI11407 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000001280.3
  ENSCAFP00030023093.1
  ENSCAFP00040032615.1
  ENSCAFP00845026158
  ENSCAFP00845026158.1
RefSeq Acc Id: NP_001300716   ⟸   NM_001313787
- Peptide Label: precursor
- UniProtKB: Q5TJG5 (UniProtKB/TrEMBL),   A0A8C0RK32 (UniProtKB/TrEMBL),   F1PSQ6 (UniProtKB/TrEMBL),   A0A8C0JMR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001280   ⟸   ENSCAFT00000001394
RefSeq Acc Id: ENSCAFP00845026158   ⟸   ENSCAFT00845033413
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000896 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014302 UniProtKB/TrEMBL
  ENSCAFG00040020227 UniProtKB/TrEMBL
  ENSCAFG00845018933 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001394.5 UniProtKB/TrEMBL
  ENSCAFT00030026455.1 UniProtKB/TrEMBL
  ENSCAFT00040037421.1 UniProtKB/TrEMBL
  ENSCAFT00845033413 ENTREZGENE
  ENSCAFT00845033413.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/TrEMBL
  MHC_II_a_N UniProtKB/TrEMBL
KEGG Report cfa:474869 UniProtKB/TrEMBL
NCBI Gene DLA-DOA ENTREZGENE
PANTHER HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_II_alpha UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
  MHC_II_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF54452 UniProtKB/TrEMBL
UniProt A0A8C0JMR7 ENTREZGENE
  A0A8C0RK32 ENTREZGENE, UniProtKB/TrEMBL
  F1PSQ6 ENTREZGENE
  Q5TJG5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1PSQ6 UniProtKB/TrEMBL