CRB1 (crumbs cell polarity complex component 1) - Rat Genome Database

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Gene: CRB1 (crumbs cell polarity complex component 1) Canis lupus familiaris
Analyze
Symbol: CRB1
Name: crumbs cell polarity complex component 1
RGD ID: 12101988
Description: ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); INVOLVED IN blood vessel remodeling (ortholog); cellular response to light stimulus (ortholog); detection of light stimulus involved in visual perception (ortholog); ASSOCIATED WITH bestrophinopathy (ortholog); cone dystrophy (ortholog); cone-rod dystrophy (ortholog); FOUND IN apical part of cell (ortholog); microvillus (ortholog); photoreceptor inner segment (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: crumbs 1, cell polarity complex component; crumbs homolog 1; protein crumbs homolog 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,277,394 - 5,490,542 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha74,896,806 - 5,113,389 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.074,967,450 - 5,180,345 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.174,909,374 - 5,120,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,009,956 - 5,223,118 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,042,374 - 5,255,595 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:25385611   PMID:30032202  


Genomics

Comparative Map Data
CRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,277,394 - 5,490,542 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha74,896,806 - 5,113,389 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.074,967,450 - 5,180,345 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.174,909,374 - 5,120,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,009,956 - 5,223,118 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,042,374 - 5,255,595 (-)NCBIUU_Cfam_GSD_1.0
CRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381197,201,504 - 197,478,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1197,268,204 - 197,478,455 (+)EnsemblGRCh38hg38GRCh38
GRCh371197,170,634 - 197,447,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361195,504,031 - 195,714,208 (+)NCBINCBI36Build 36hg18NCBI36
Build 341193,969,064 - 194,179,241NCBI
Celera1170,362,823 - 170,573,037 (+)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1168,328,124 - 168,606,472 (+)NCBIHuRef
CHM1_11198,593,055 - 198,870,040 (+)NCBICHM1_1
T2T-CHM13v2.01196,463,303 - 196,740,260 (+)NCBIT2T-CHM13v2.0
Crb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391139,101,288 - 139,307,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1139,124,794 - 139,304,838 (-)EnsemblGRCm39 Ensembl
GRCm381139,176,649 - 139,379,316 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1139,197,056 - 139,377,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,094,831 - 141,273,653 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,014,754 - 141,193,452 (-)NCBIMGSCv36mm8
Celera1141,833,551 - 142,013,612 (-)NCBICelera
Cytogenetic Map1E4- FNCBI
cM Map160.87NCBI
Crb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81353,352,932 - 53,540,019 (-)NCBIGRCr8
mRatBN7.21350,801,484 - 50,989,261 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1350,800,959 - 50,989,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1353,408,027 - 53,587,968 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01354,695,960 - 54,875,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01351,963,725 - 52,151,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,270,519 - 56,462,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,270,781 - 56,462,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,413,282 - 61,480,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01361,292,273 - 61,369,526 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,558,317 - 52,725,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11352,572,656 - 52,715,591 (-)NCBI
Celera1351,073,846 - 51,253,703 (-)NCBICelera
Cytogenetic Map13q13NCBI
Crb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540633,817,605 - 34,005,943 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540633,817,754 - 34,005,937 (+)NCBIChiLan1.0ChiLan1.0
CRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2151,895,729 - 52,177,256 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1151,867,477 - 52,146,450 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,794,523 - 173,076,045 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11177,174,431 - 177,389,289 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1177,174,431 - 177,422,867 (+)Ensemblpanpan1.1panPan2
Crb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934477,112,995 - 77,325,150 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365676,366,489 - 6,559,766 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365676,347,661 - 6,559,731 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1020,137,451 - 20,332,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11020,137,246 - 20,332,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21024,720,738 - 24,900,728 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12531,710,712 - 32,143,121 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2531,906,803 - 32,088,995 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605532,840,856 - 33,051,363 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247982,861,520 - 2,999,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247982,861,481 - 2,999,387 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRB1
2200 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 7 8
Below cutoff 5 5 16 1 4 1 6 6 5 10 6

Sequence


RefSeq Acc Id: ENSCAFT00000018057   ⟹   ENSCAFP00000016724
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000039475   ⟹   ENSCAFP00000035333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070236   ⟹   ENSCAFP00000057422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000074364   ⟹   ENSCAFP00000065517
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl75,277,394 - 5,490,470 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001740   ⟹   ENSCAFP00845001375
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001767   ⟹   ENSCAFP00845001395
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001795   ⟹   ENSCAFP00845001413
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001802   ⟹   ENSCAFP00845001419
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001818   ⟹   ENSCAFP00845001432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl74,967,446 - 5,180,191 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001834   ⟹   ENSCAFP00845001445
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl74,967,486 - 5,180,191 (-)Ensembl
RefSeq Acc Id: XM_005622293   ⟹   XP_005622350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.175,277,394 - 5,490,542 (-)NCBI
Dog10K_Boxer_Tasha74,896,806 - 5,113,389 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038480659   ⟹   XP_038336587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.174,909,374 - 5,120,084 (-)NCBI
RefSeq Acc Id: XM_038541982   ⟹   XP_038397910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.075,042,374 - 5,255,595 (-)NCBI
RefSeq Acc Id: XM_038541983   ⟹   XP_038397911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.075,042,374 - 5,253,254 (-)NCBI
RefSeq Acc Id: XM_038561594   ⟹   XP_038417522
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha74,896,806 - 5,111,048 (-)NCBI
RefSeq Acc Id: XM_038606117   ⟹   XP_038462045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.075,009,956 - 5,223,118 (-)NCBI
RefSeq Acc Id: XM_038606118   ⟹   XP_038462046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.075,009,956 - 5,220,777 (-)NCBI
RefSeq Acc Id: XM_038670808   ⟹   XP_038526736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.074,967,450 - 5,180,345 (-)NCBI
RefSeq Acc Id: XM_038670809   ⟹   XP_038526737
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.074,967,450 - 5,178,004 (-)NCBI
RefSeq Acc Id: XP_005622350   ⟸   XM_005622293
- Peptide Label: isoform X1
- UniProtKB: A0A8P0ND97 (UniProtKB/TrEMBL),   A0A8C0P6D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035333   ⟸   ENSCAFT00000039475
RefSeq Acc Id: ENSCAFP00000065517   ⟸   ENSCAFT00000074364
RefSeq Acc Id: ENSCAFP00000057422   ⟸   ENSCAFT00000070236
RefSeq Acc Id: ENSCAFP00000016724   ⟸   ENSCAFT00000018057
RefSeq Acc Id: XP_038336587   ⟸   XM_038480659
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038462045   ⟸   XM_038606117
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038462046   ⟸   XM_038606118
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038526736   ⟸   XM_038670808
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RPL4 (UniProtKB/TrEMBL),   A0A8C0P6D6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038526737   ⟸   XM_038670809
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038417522   ⟸   XM_038561594
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038397910   ⟸   XM_038541982
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P6D6 (UniProtKB/TrEMBL),   A0A8P0ND97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038397911   ⟸   XM_038541983
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KHK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001375   ⟸   ENSCAFT00845001740
RefSeq Acc Id: ENSCAFP00845001419   ⟸   ENSCAFT00845001802
RefSeq Acc Id: ENSCAFP00845001395   ⟸   ENSCAFT00845001767
RefSeq Acc Id: ENSCAFP00845001413   ⟸   ENSCAFT00845001795
RefSeq Acc Id: ENSCAFP00845001432   ⟸   ENSCAFT00845001818
RefSeq Acc Id: ENSCAFP00845001445   ⟸   ENSCAFT00845001834
Protein Domains
EGF-like   Laminin G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011365 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022598 UniProtKB/TrEMBL
  ENSCAFG00845000998 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018057.5 UniProtKB/TrEMBL
  ENSCAFT00000039475.4 UniProtKB/TrEMBL
  ENSCAFT00000070236.2 UniProtKB/TrEMBL
  ENSCAFT00000074364.2 UniProtKB/TrEMBL
  ENSCAFT00000098368.1 UniProtKB/TrEMBL
  ENSCAFT00000107872.1 UniProtKB/TrEMBL
  ENSCAFT00030041632.1 UniProtKB/TrEMBL
  ENSCAFT00030041700.1 UniProtKB/TrEMBL
  ENSCAFT00030041731.1 UniProtKB/TrEMBL
  ENSCAFT00030041805.1 UniProtKB/TrEMBL
  ENSCAFT00030041849.1 UniProtKB/TrEMBL
  ENSCAFT00845001740 ENTREZGENE
  ENSCAFT00845001740.1 UniProtKB/TrEMBL
  ENSCAFT00845001767.1 UniProtKB/TrEMBL
  ENSCAFT00845001795.1 UniProtKB/TrEMBL
  ENSCAFT00845001802.1 UniProtKB/TrEMBL
  ENSCAFT00845001818.1 UniProtKB/TrEMBL
  ENSCAFT00845001834.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
KEGG Report cfa:490260 UniProtKB/TrEMBL
NCBI Gene CRB1 ENTREZGENE
PANTHER CRUMBS CELL POLARITY COMPLEX COMPONENT 2B UniProtKB/TrEMBL
  CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/TrEMBL
  PROTEIN CRUMBS HOMOLOG 1 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
  NOTCH UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0KHK6 ENTREZGENE
  A0A8C0P3T9_CANLF UniProtKB/TrEMBL
  A0A8C0P6D6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PAW9_CANLF UniProtKB/TrEMBL
  A0A8C0PB42_CANLF UniProtKB/TrEMBL
  A0A8C0PKH2_CANLF UniProtKB/TrEMBL
  A0A8I3MDN0_CANLF UniProtKB/TrEMBL
  A0A8I3MG92_CANLF UniProtKB/TrEMBL
  A0A8I3MGB2_CANLF UniProtKB/TrEMBL
  A0A8I3MJG1_CANLF UniProtKB/TrEMBL
  A0A8I3RPL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR84_CANLF UniProtKB/TrEMBL
  A0A8P0ND97 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PE22_CANLF UniProtKB/TrEMBL
  A0A8P0PLI4_CANLF UniProtKB/TrEMBL
  A0A8P0SQT6_CANLF UniProtKB/TrEMBL
  A0A8P0T9I6_CANLF UniProtKB/TrEMBL
  A0A8P0TRH8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:39593 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 CRB1  crumbs cell polarity complex component 1    crumbs 1, cell polarity complex component  Symbol and/or name change 5135510 APPROVED