SV2C (synaptic vesicle glycoprotein 2C) - Rat Genome Database

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Gene: SV2C (synaptic vesicle glycoprotein 2C) Canis lupus familiaris
Analyze
Symbol: SV2C
Name: synaptic vesicle glycoprotein 2C
RGD ID: 12101090
Description: ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN chemical synaptic transmission (inferred); neurotransmitter transport (inferred); regulation of synaptic vesicle exocytosis (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); spinal muscular atrophy (ortholog); FOUND IN dopaminergic synapse (ortholog); synaptic vesicle (ortholog); synaptic vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1330,232,892 - 30,440,046 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,232,710 - 30,440,327 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,469,780 - 31,678,170 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0330,156,170 - 30,363,724 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl330,156,894 - 30,363,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1330,087,278 - 30,241,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0330,066,666 - 30,270,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,437,678 - 30,645,896 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SV2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1330,232,892 - 30,440,046 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,232,710 - 30,440,327 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,469,780 - 31,678,170 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0330,156,170 - 30,363,724 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl330,156,894 - 30,363,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1330,087,278 - 30,241,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0330,066,666 - 30,270,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,437,678 - 30,645,896 (-)NCBIUU_Cfam_GSD_1.0
SV2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38575,847,464 - 76,353,939 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,083,383 - 76,353,939 (+)EnsemblGRCh38hg38GRCh38
GRCh37575,379,208 - 75,649,764 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36575,415,061 - 75,657,172 (+)NCBINCBI36Build 36hg18NCBI36
Build 34575,526,658 - 75,661,645NCBI
Celera571,320,469 - 71,515,084 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef570,632,037 - 70,829,092 (+)NCBIHuRef
CHM1_1574,860,605 - 75,054,059 (+)NCBICHM1_1
T2T-CHM13v2.0576,328,570 - 76,835,704 (+)NCBIT2T-CHM13v2.0
Sv2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391396,091,102 - 96,270,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1396,091,102 - 96,269,085 (-)EnsemblGRCm39 Ensembl
GRCm381395,959,443 - 96,132,577 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,954,594 - 96,132,577 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,729,398 - 96,902,532 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361397,060,142 - 97,233,276 (-)NCBIMGSCv36mm8
Celera1399,577,609 - 99,753,046 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.47NCBI
Sv2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,967,631 - 29,163,168 (-)NCBIGRCr8
mRatBN7.2227,232,933 - 27,428,479 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,232,933 - 27,428,477 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx234,272,667 - 34,465,181 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0232,372,766 - 32,565,287 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,188,759 - 27,389,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0226,495,757 - 26,707,691 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,501,833 - 26,699,333 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,631,737 - 45,828,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,326,862 - 26,555,019 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1226,247,230 - 26,475,388 (-)NCBI
Celera223,293,289 - 23,483,743 (-)NCBICelera
Cytogenetic Map2q12NCBI
Sv2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542524,496,434 - 24,683,179 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542524,489,304 - 24,682,555 (-)NCBIChiLan1.0ChiLan1.0
SV2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,969,968 - 39,223,327 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1537,123,598 - 37,376,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,969,056 - 39,222,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1539,566,207 - 39,836,653 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,566,207 - 39,836,852 (-)Ensemblpanpan1.1panPan2
Sv2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,039,748 - 190,265,745 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549590,978 - 765,741 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549592,975 - 819,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SV2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,996,716 - 85,236,130 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,996,697 - 85,235,827 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2286,622,023 - 86,679,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SV2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,358,164 - 70,601,764 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,358,236 - 70,601,242 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,160,261 - 19,408,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sv2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624869669,391 - 831,138 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624869611,873 - 838,014 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SV2C
2832 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 18 6 6 4 12 2
Below cutoff 1 5 4 6 2 6 8 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014862   ⟹   ENSCAFP00000013754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl330,232,710 - 30,440,327 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019289   ⟹   ENSCAFP00845015076
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl330,156,894 - 30,363,969 (-)Ensembl
RefSeq Acc Id: XM_022416774   ⟹   XP_022272482
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1330,232,892 - 30,387,070 (-)NCBI
Dog10K_Boxer_Tasha331,469,780 - 31,625,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038471585   ⟹   XP_038327513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1330,087,278 - 30,241,695 (-)NCBI
RefSeq Acc Id: XM_038532517   ⟹   XP_038388445
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0330,438,315 - 30,645,896 (-)NCBI
RefSeq Acc Id: XM_038532518   ⟹   XP_038388446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0330,437,678 - 30,592,997 (-)NCBI
RefSeq Acc Id: XM_038596797   ⟹   XP_038452725
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0330,067,284 - 30,270,719 (-)NCBI
RefSeq Acc Id: XM_038596798   ⟹   XP_038452726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0330,066,666 - 30,217,882 (-)NCBI
RefSeq Acc Id: XM_038661009   ⟹   XP_038516937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0330,156,894 - 30,363,724 (-)NCBI
RefSeq Acc Id: XM_038661010   ⟹   XP_038516938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0330,156,170 - 30,310,763 (-)NCBI
RefSeq Acc Id: XM_546060   ⟹   XP_546060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1330,233,009 - 30,440,046 (-)NCBI
Dog10K_Boxer_Tasha331,470,479 - 31,678,170 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_546060   ⟸   XM_546060
- UniProtKB: A0A8C0LK27 (UniProtKB/TrEMBL),   A0A8C0MWS1 (UniProtKB/TrEMBL),   A0A8I3RYA0 (UniProtKB/TrEMBL),   A0A8C0PX20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022272482   ⟸   XM_022416774
- UniProtKB: A0A8C0LK27 (UniProtKB/TrEMBL),   A0A8C0MWS1 (UniProtKB/TrEMBL),   A0A8I3RYA0 (UniProtKB/TrEMBL),   A0A8C0PX20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000013754   ⟸   ENSCAFT00000014862
RefSeq Acc Id: XP_038327513   ⟸   XM_038471585
RefSeq Acc Id: XP_038452726   ⟸   XM_038596798
RefSeq Acc Id: XP_038452725   ⟸   XM_038596797
RefSeq Acc Id: XP_038516938   ⟸   XM_038661010
- UniProtKB: A0A8C0LK27 (UniProtKB/TrEMBL),   A0A8C0MWS1 (UniProtKB/TrEMBL),   A0A8I3RYA0 (UniProtKB/TrEMBL),   A0A8C0PX20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038516937   ⟸   XM_038661009
- UniProtKB: A0A8C0LK27 (UniProtKB/TrEMBL),   A0A8C0MWS1 (UniProtKB/TrEMBL),   A0A8I3RYA0 (UniProtKB/TrEMBL),   A0A8C0PX20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038388446   ⟸   XM_038532518
- UniProtKB: A0A8C0LK27 (UniProtKB/TrEMBL),   A0A8C0MWS1 (UniProtKB/TrEMBL),   A0A8C0PX20 (UniProtKB/TrEMBL),   A0A8I3RYA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038388445   ⟸   XM_038532517
- UniProtKB: A0A8C0LK27 (UniProtKB/TrEMBL),   A0A8C0MWS1 (UniProtKB/TrEMBL),   A0A8C0PX20 (UniProtKB/TrEMBL),   A0A8I3RYA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845015076   ⟸   ENSCAFT00845019289
Protein Domains
Major facilitator superfamily (MFS) profile

Promoters
RGD ID:13682707
Promoter ID:EPDNEW_C776
Type:single initiation site
Name:SV2C_1
Description:synaptic vesicle glycoprotein 2C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1330,440,080 - 30,440,140EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009330 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009939 UniProtKB/TrEMBL
  ENSCAFG00040002141 UniProtKB/TrEMBL
  ENSCAFG00845010918 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014862.5 UniProtKB/TrEMBL
  ENSCAFT00030018388.1 UniProtKB/TrEMBL
  ENSCAFT00040004144.1 UniProtKB/TrEMBL
  ENSCAFT00845019289 ENTREZGENE
  ENSCAFT00845019289.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
  E3 ubiquitin-protein ligase SopA UniProtKB/TrEMBL
InterPro 5peptide_repeat UniProtKB/TrEMBL
  MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
  SV2 UniProtKB/TrEMBL
NCBI Gene SV2C ENTREZGENE
PANTHER SYNAPTIC VESICLE GLYCOPROTEIN 2 UniProtKB/TrEMBL
  SYNAPTIC VESICLE GLYCOPROTEIN 2C UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
  Pentapeptide_4 UniProtKB/TrEMBL
  Sugar_tr UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/TrEMBL
Superfamily-SCOP Pentapeptide repeat-like UniProtKB/TrEMBL
  SSF103473 UniProtKB/TrEMBL
UniProt A0A8C0LK27 ENTREZGENE
  A0A8C0MWS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PX20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RYA0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47005 ENTREZGENE