BPIFB4 (BPI fold containing family B member 4) - Rat Genome Database

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Gene: BPIFB4 (BPI fold containing family B member 4) Canis lupus familiaris
Analyze
Symbol: BPIFB4
Name: BPI fold containing family B member 4
RGD ID: 12099079
Description: ENCODES a protein that exhibits lipid binding (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BPI fold-containing family B member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,343,202 - 22,371,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,344,828 - 22,369,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,988,777 - 22,015,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,028,889 - 23,057,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,028,850 - 23,055,728 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,304,485 - 22,331,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,414,400 - 22,442,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,845,542 - 22,873,932 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21787330   PMID:21787333   PMID:22301074  


Genomics

Comparative Map Data
BPIFB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,343,202 - 22,371,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,344,828 - 22,369,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,988,777 - 22,015,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,028,889 - 23,057,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,028,850 - 23,055,728 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,304,485 - 22,331,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,414,400 - 22,442,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,845,542 - 22,873,932 (+)NCBIUU_Cfam_GSD_1.0
BPIFB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,079,643 - 33,111,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,079,643 - 33,111,751 (+)EnsemblGRCh38hg38GRCh38
GRCh372031,667,449 - 31,699,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,134,416 - 31,163,218 (+)NCBINCBI36Build 36hg18NCBI36
Build 342031,134,415 - 31,163,217NCBI
Celera2028,423,195 - 28,453,431 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2028,456,441 - 28,486,360 (+)NCBIHuRef
CHM1_12031,569,450 - 31,600,637 (+)NCBICHM1_1
T2T-CHM13v2.02034,806,383 - 34,838,494 (+)NCBIT2T-CHM13v2.0
Bpifb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,780,137 - 153,805,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,780,141 - 153,806,021 (+)EnsemblGRCm39 Ensembl
GRCm382153,938,217 - 153,963,852 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,938,221 - 153,964,101 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,938,212 - 153,964,101 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,766,598 - 153,789,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,635,364 - 153,655,293 (+)NCBIMGSCv36mm8
Celera2159,777,486 - 159,800,795 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.99NCBI
Bpifb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,881,478 - 162,908,207 (+)NCBIGRCr8
mRatBN7.23142,423,571 - 142,448,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,400,976 - 142,448,044 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,325,494 - 146,349,942 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03154,909,321 - 154,933,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03152,649,656 - 152,674,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,424,392 - 149,449,350 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,424,392 - 149,449,350 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,802,169 - 155,827,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,325,761 - 144,350,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3141,164,705 - 141,189,176 (+)NCBICelera
Cytogenetic Map3q41NCBI
Bpifb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,167,179 - 28,188,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,166,892 - 28,190,403 (-)NCBIChiLan1.0ChiLan1.0
BPIFB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22138,768,992 - 38,801,037 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,762,097 - 38,794,222 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,365,756 - 29,397,786 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12030,484,734 - 30,516,954 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2030,484,734 - 30,516,954 (+)Ensemblpanpan1.1panPan2
Bpifb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,331,449 - 171,352,876 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648519,764,242 - 19,783,943 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648519,764,242 - 19,783,963 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BPIFB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1736,609,798 - 36,639,034 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11736,609,805 - 36,639,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,526,418 - 41,541,772 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BPIFB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,447,136 - 37,479,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,449,440 - 37,476,276 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605089,424,247 - 89,454,738 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bpifb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248426,194,389 - 6,225,515 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248426,194,291 - 6,225,515 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BPIFB4
431 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5
Low 3 4 1 8 4 1
Below cutoff 5 5 13 5 2 5 6 4 6 6 5

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022409494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038509628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038509629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038571998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038571999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000011771   ⟹   ENSCAFP00000010910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2422,344,828 - 22,369,974 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845041121   ⟹   ENSCAFP00845032226
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2423,028,850 - 23,055,728 (+)Ensembl
RefSeq Acc Id: XM_038433503   ⟹   XP_038289431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02423,028,889 - 23,057,272 (+)NCBI
RefSeq Acc Id: XM_038433504   ⟹   XP_038289432
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02423,028,903 - 23,057,272 (+)NCBI
RefSeq Acc Id: XM_038457770   ⟹   XP_038313698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2421,988,777 - 22,015,736 (+)NCBI
RefSeq Acc Id: XM_038457771   ⟹   XP_038313699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2421,988,791 - 22,015,736 (+)NCBI
RefSeq Acc Id: XM_038509628   ⟹   XP_038365556
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12422,304,485 - 22,331,438 (+)NCBI
RefSeq Acc Id: XM_038509629   ⟹   XP_038365557
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12422,304,499 - 22,331,438 (+)NCBI
RefSeq Acc Id: XM_038571998   ⟹   XP_038427926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02422,845,542 - 22,873,932 (+)NCBI
RefSeq Acc Id: XM_038571999   ⟹   XP_038427927
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02422,845,556 - 22,873,932 (+)NCBI
RefSeq Acc Id: XM_038636253   ⟹   XP_038492181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02422,414,400 - 22,442,868 (+)NCBI
RefSeq Acc Id: XM_038636254   ⟹   XP_038492182
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02422,414,414 - 22,442,868 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000010910   ⟸   ENSCAFT00000011771
RefSeq Acc Id: XP_038365556   ⟸   XM_038509628
RefSeq Acc Id: XP_038365557   ⟸   XM_038509629
RefSeq Acc Id: XP_038492181   ⟸   XM_038636253
RefSeq Acc Id: XP_038492182   ⟸   XM_038636254
RefSeq Acc Id: XP_038289431   ⟸   XM_038433503
- UniProtKB: A0A8C0QM20 (UniProtKB/TrEMBL),   A0A8I3PIZ8 (UniProtKB/TrEMBL),   A0A8C0JVG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038289432   ⟸   XM_038433504
- UniProtKB: A0A8C0QM20 (UniProtKB/TrEMBL),   A0A8I3PIZ8 (UniProtKB/TrEMBL),   A0A8C0JVG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313698   ⟸   XM_038457770
- UniProtKB: A0A8C0QM20 (UniProtKB/TrEMBL),   A0A8I3PIZ8 (UniProtKB/TrEMBL),   A0A8C0JVG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038313699   ⟸   XM_038457771
- UniProtKB: A0A8C0QM20 (UniProtKB/TrEMBL),   A0A8I3PIZ8 (UniProtKB/TrEMBL),   A0A8C0JVG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038427926   ⟸   XM_038571998
- UniProtKB: A0A8C0JVG4 (UniProtKB/TrEMBL),   A0A8C0QM20 (UniProtKB/TrEMBL),   A0A8I3PIZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038427927   ⟸   XM_038571999
- UniProtKB: A0A8C0JVG4 (UniProtKB/TrEMBL),   A0A8C0QM20 (UniProtKB/TrEMBL),   A0A8I3PIZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032226   ⟸   ENSCAFT00845041121
Protein Domains
Lipid-binding serum glycoprotein C-terminal   Lipid-binding serum glycoprotein N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007356 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018001 UniProtKB/TrEMBL
  ENSCAFG00040005893 UniProtKB/TrEMBL
  ENSCAFG00845023291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011771.6 UniProtKB/TrEMBL
  ENSCAFT00030033179.1 UniProtKB/TrEMBL
  ENSCAFT00030033276.1 UniProtKB/TrEMBL
  ENSCAFT00040011027.1 UniProtKB/TrEMBL
  ENSCAFT00845041121 ENTREZGENE
  ENSCAFT00845041121.1 UniProtKB/TrEMBL
InterPro Bactericidal_perm-incr_a/b_dom UniProtKB/TrEMBL
  Lipid-bd_serum_glycop_C UniProtKB/TrEMBL
  Lipid-bd_serum_glycop_N UniProtKB/TrEMBL
NCBI Gene BPIFB4 ENTREZGENE
PANTHER BPI FOLD-CONTAINING FAMILY B MEMBER 4 UniProtKB/TrEMBL
  BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED UniProtKB/TrEMBL
Pfam LBP_BPI_CETP UniProtKB/TrEMBL
  LBP_BPI_CETP_C UniProtKB/TrEMBL
SMART BPI1 UniProtKB/TrEMBL
  BPI2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55394 UniProtKB/TrEMBL
UniProt A0A8C0JVG4 ENTREZGENE
  A0A8C0NUE0_CANLF UniProtKB/TrEMBL
  A0A8C0QM20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PIZ8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38510 ENTREZGENE