AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1) Canis lupus familiaris
Analyze
Symbol: AREL1
Name: apoptosis resistant E3 ubiquitin protein ligase 1
RGD ID: 12098685
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN negative regulation of apoptotic process (inferred); protein K11-linked ubiquitination (inferred); protein K33-linked ubiquitination (inferred); ASSOCIATED WITH endometrial carcinoma (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-resistant E3 ubiquitin protein ligase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,798,946 - 47,819,364 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,801,895 - 47,819,318 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,482,601 - 47,525,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,025,898 - 48,069,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,026,855 - 48,069,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,696,920 - 47,740,078 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,718,274 - 47,761,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,116,253 - 48,159,412 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AREL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,798,946 - 47,819,364 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,801,895 - 47,819,318 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,482,601 - 47,525,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,025,898 - 48,069,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,026,855 - 48,069,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,696,920 - 47,740,078 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,718,274 - 47,761,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,116,253 - 48,159,412 (-)NCBIUU_Cfam_GSD_1.0
AREL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,661,256 - 74,713,080 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,653,437 - 74,713,117 (-)EnsemblGRCh38hg38GRCh38
GRCh371475,127,959 - 75,179,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,197,708 - 74,249,560 (-)NCBINCBI36Build 36hg18NCBI36
Build 341474,189,634 - 74,249,560NCBI
Celera1455,166,339 - 55,218,171 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,296,047 - 55,347,878 (-)NCBIHuRef
CHM1_11475,067,096 - 75,118,955 (-)NCBICHM1_1
T2T-CHM13v2.01468,870,372 - 68,922,179 (-)NCBIT2T-CHM13v2.0
Arel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,964,914 - 85,017,674 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,964,922 - 85,017,674 (-)EnsemblGRCm39 Ensembl
GRCm381284,918,140 - 84,970,878 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,918,148 - 84,970,900 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,259,098 - 86,311,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,807,494 - 85,840,311 (-)NCBIMGSCv36mm8
Celera1286,375,198 - 86,428,152 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.46NCBI
Arel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,296,072 - 110,348,751 (-)NCBIGRCr8
mRatBN7.26104,560,556 - 104,617,712 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,564,986 - 104,617,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,734,704 - 104,763,166 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,033,876 - 105,062,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,403,226 - 104,431,688 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,630,790 - 108,796,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,635,220 - 108,796,124 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,882,562 - 116,922,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,963,520 - 108,992,271 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,969,035 - 108,999,416 (-)NCBI
Celera6102,388,676 - 102,416,454 (-)NCBICelera
Cytogenetic Map6q31NCBI
Arel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523818,535 - 874,189 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955523818,535 - 874,189 (+)NCBIChiLan1.0ChiLan1.0
AREL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,744,134 - 75,795,871 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,960,644 - 75,012,411 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,213,600 - 55,265,198 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,060,648 - 74,112,165 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,060,653 - 74,112,165 (-)Ensemblpanpan1.1panPan2
Arel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,186,925 - 28,233,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,835,075 - 3,876,403 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,835,021 - 3,882,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AREL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,875,220 - 97,940,876 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,893,182 - 97,940,932 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,736,289 - 103,783,732 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AREL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,877,074 - 51,928,042 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605340,104,994 - 40,156,793 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,960,548 - 27,009,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,960,511 - 27,014,369 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AREL1
146 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 1 16 5 2 5 4 11 7 10
Low 3 4 6 1 4 1 2 6 1 1 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022422459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038483788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038545269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038591200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038591204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038591207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038609366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000026863   ⟹   ENSCAFP00000024966
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl847,801,895 - 47,819,318 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025989   ⟹   ENSCAFP00845020488
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl848,026,855 - 48,069,067 (-)Ensembl
RefSeq Acc Id: XM_038483786   ⟹   XP_038339714
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1847,696,920 - 47,740,078 (-)NCBI
RefSeq Acc Id: XM_038483787   ⟹   XP_038339715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1847,696,920 - 47,740,078 (-)NCBI
RefSeq Acc Id: XM_038483788   ⟹   XP_038339716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1847,696,920 - 47,740,078 (-)NCBI
RefSeq Acc Id: XM_038545267   ⟹   XP_038401195
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0848,116,253 - 48,159,412 (-)NCBI
RefSeq Acc Id: XM_038545268   ⟹   XP_038401196
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0848,116,253 - 48,159,412 (-)NCBI
RefSeq Acc Id: XM_038545269   ⟹   XP_038401197
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0848,116,253 - 48,159,412 (-)NCBI
RefSeq Acc Id: XM_038591200   ⟹   XP_038447128
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha847,482,601 - 47,525,768 (-)NCBI
RefSeq Acc Id: XM_038591204   ⟹   XP_038447132
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha847,482,601 - 47,525,768 (-)NCBI
RefSeq Acc Id: XM_038591207   ⟹   XP_038447135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha847,482,601 - 47,525,768 (-)NCBI
RefSeq Acc Id: XM_038609363   ⟹   XP_038465291
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0847,718,274 - 47,761,437 (-)NCBI
RefSeq Acc Id: XM_038609364   ⟹   XP_038465292
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0847,718,274 - 47,761,437 (-)NCBI
RefSeq Acc Id: XM_038609366   ⟹   XP_038465294
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0847,718,274 - 47,761,437 (-)NCBI
RefSeq Acc Id: XM_038674187   ⟹   XP_038530115
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0848,025,898 - 48,069,077 (-)NCBI
RefSeq Acc Id: XM_038674188   ⟹   XP_038530116
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0848,025,898 - 48,069,077 (-)NCBI
RefSeq Acc Id: XM_038674189   ⟹   XP_038530117
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0848,025,898 - 48,069,077 (-)NCBI
RefSeq Acc Id: ENSCAFP00000024966   ⟸   ENSCAFT00000026863
RefSeq Acc Id: XP_038339716   ⟸   XM_038483788
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038339715   ⟸   XM_038483787
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038339714   ⟸   XM_038483786
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038465294   ⟸   XM_038609366
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038465292   ⟸   XM_038609364
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038465291   ⟸   XM_038609363
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038530117   ⟸   XM_038674189
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530116   ⟸   XM_038674188
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NJX8 (UniProtKB/TrEMBL),   A0A8P0SL68 (UniProtKB/TrEMBL),   A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530115   ⟸   XM_038674187
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QUI6 (UniProtKB/TrEMBL),   A0A8C0SCP6 (UniProtKB/TrEMBL),   A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038447135   ⟸   XM_038591207
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038447132   ⟸   XM_038591204
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NJX8 (UniProtKB/TrEMBL),   A0A8P0SL68 (UniProtKB/TrEMBL),   A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038447128   ⟸   XM_038591200
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QUI6 (UniProtKB/TrEMBL),   A0A8C0SCP6 (UniProtKB/TrEMBL),   A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401197   ⟸   XM_038545269
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JRA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401196   ⟸   XM_038545268
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JRA9 (UniProtKB/TrEMBL),   A0A8I3NJX8 (UniProtKB/TrEMBL),   A0A8P0SL68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038401195   ⟸   XM_038545267
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JRA9 (UniProtKB/TrEMBL),   A0A8C0QUI6 (UniProtKB/TrEMBL),   A0A8C0SCP6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020488   ⟸   ENSCAFT00845025989
Protein Domains
HECT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016962 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040011980 UniProtKB/TrEMBL
  ENSCAFG00845014520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026863.5 UniProtKB/TrEMBL
  ENSCAFT00040022079.1 UniProtKB/TrEMBL
  ENSCAFT00040022144.1 UniProtKB/TrEMBL
  ENSCAFT00845025989 ENTREZGENE
  ENSCAFT00845025989.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
NCBI Gene AREL1 ENTREZGENE
PANTHER APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam Filamin UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
Superfamily-SCOP SSF56204 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A8C0JRA9 ENTREZGENE
  A0A8C0QUI6 ENTREZGENE
  A0A8C0SCP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SCU4_CANLF UniProtKB/TrEMBL
  A0A8I3NJX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SL68 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38029 ENTREZGENE