LOC100686511 (myeloid cell surface antigen CD33)

Gene: LOC100686511 (myeloid cell surface antigen CD33) Canis lupus familiaris

Analyze

Symbol:

LOC100686511

Name:

myeloid cell surface antigen CD33

RGD ID:

12097270

Description:

ENCODES a protein that exhibits protein phosphatase binding (ortholog); protein tyrosine phosphatase activator activity (ortholog); INVOLVED IN cell-cell adhesion (ortholog); Fc-gamma receptor signaling pathway (ortholog); immune response-inhibiting signal transduction (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); Golgi apparatus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

CD33; CD33 molecule

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	105,722,187 - 105,731,616 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	105,294,588 - 105,304,256 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	106,231,215 - 106,240,879 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	1	105,903,008 - 105,912,671 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	105,543,870 - 105,553,532 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	106,339,280 - 106,348,950 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Alzheimer's disease (ISO)

genetic disease (ISO)

multiple acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

cell-cell adhesion (ISO)

Fc-gamma receptor signaling pathway (ISO)

immune response-inhibiting signal transduction (ISO)

negative regulation of interleukin-1 beta production (ISO)

negative regulation of interleukin-8 production (ISO)

negative regulation of monocyte activation (ISO)

negative regulation of tumor necrosis factor production (ISO)

positive regulation of protein secretion (ISO)

Cellular Component

cell surface (ISO)

external side of plasma membrane (ISO)

Golgi apparatus (ISO)

membrane (IEA)

nucleoplasm (ISO)

peroxisome (ISO)

plasma membrane (IEA)

Molecular Function

carbohydrate binding (IEA)

protein binding (ISO)

protein phosphatase binding (ISO)

protein tyrosine phosphatase activator activity (ISO)

sialic acid binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LOC100686511
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	105,722,187 - 105,731,616 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	105,294,588 - 105,304,256 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	106,231,215 - 106,240,879 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	1	105,903,008 - 105,912,671 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	105,543,870 - 105,553,532 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	106,339,280 - 106,348,950 (-)	NCBI		UU_Cfam_GSD_1.0

CD33
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	51,211,076 - 51,240,016 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	51,225,064 - 51,243,860 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	51,728,336 - 51,743,271 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	56,420,147 - 56,435,086 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	56,420,174 - 56,435,084	NCBI
Celera	19	48,780,420 - 48,795,363 (+)	NCBI		Celera
Cytogenetic Map	19	q13.41	NCBI
HuRef	19	48,061,383 - 48,076,328 (+)	NCBI		HuRef
CHM1_1	19	51,730,399 - 51,745,342 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	54,304,101 - 54,328,637 (+)	NCBI		T2T-CHM13v2.0

Cd33
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	43,176,823 - 43,186,679 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	43,173,640 - 43,193,852 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	43,527,399 - 43,537,424 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	43,524,216 - 43,544,428 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	50,782,826 - 50,788,541 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	43,396,037 - 43,401,143 (-)	NCBI		MGSCv36	mm8
Celera	7	38,996,297 - 39,002,012 (-)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	28.25	NCBI

Cd33
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	103,071,985 - 103,086,687 (-)	NCBI		GRCr8
mRatBN7.2	1	93,935,418 - 93,940,452 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	93,930,971 - 93,950,149 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	98,388,811 - 98,403,539 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	98,398,660 - 98,402,968 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	99,475,380 - 99,480,079 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	93,904,033 - 93,910,383 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	88,211,524 - 88,226,240 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

LOC100983058
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	57,264,065 - 57,279,033 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	59,185,554 - 59,200,518 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	48,161,860 - 48,176,824 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	57,049,009 - 57,063,958 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	57,049,009 - 57,063,958 (+)	Ensembl	panpan1.1		panPan2

LOC110261034
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	55,745,864 - 55,778,989 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CD33
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	44,149,695 - 44,166,710 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	44,156,925 - 44,166,487 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	24,201,799 - 24,213,530 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in LOC100686511
90 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			2	2	6	2					4
Low	4		20	4		4	6		8		6	6
Below cutoff	1	5						5	4	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005616249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038467334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038528027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038592328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038656126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005616249 ⟹ XP_005616306

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	105,722,187 - 105,731,616 (-)	NCBI
Dog10K_Boxer_Tasha	1	105,294,588 - 105,304,256 (-)	NCBI

Sequence:

show sequence

TCCTCCCCAGCTTCTCATGGGTCCTTCCCAGCACCAATCCTACTGGCTTTCACTTCTCCTTCAC
CCACAGGAAGCCTACATACCCTCTTGTCTAGGATGCTGCTCCTGCTGCTGCCCATACTGTGGGC
AGTTGAATGGGCCCAGGGGAAGGTGAAGTTGGGAGCCTCTGCCGACGCTGGAGTCCCAAGATCC
TTGGCTCAAGATCCGATATACTGGCTACAAATACAGGAGTCCCTGACGGTGCAGGAGGGCCTGT
GCATCTCTGTGCCCTGCTACTTCTCCTACCCCATGGAATACTGGATCAAGACTTACTCTGCTTT
GGGCTACTGGTTCCGGAATGGGACCAATGTACATTGGGGTGCTCCAGTGGCCACAAACAACCCA
GATCGAAAAGTACAAGAGGAGACCCAGGGCCAATTCTTCCTACTTGGGGACCCTCAGGCCAACA
ACTGCTCCCTGGAGATCAGAGATGCACAAAGAAGGGACTCAGGGACATACTTCTTTAGGGTGGA
GAGAGGGCCTTATTTGAAATATAGTTACCTACAGAACCAGCTCTCCGTGCATGTGACAGCCCTG
ACCCATACACCTGACATCCTCATACCAGGGACCCTGGAATCTGGCCACCCCAGGAACCTGACCT
GCTCTGTGCCCTGGGCTTGTGAGCAGGGCATACCCCCCATCTTCTCCTGGATGTCAGCTGCCCT
TACCTCCCTGGGCCCCAGGACCCACCTCTCCTCGGTGCTCACCCTCACCCCCAGGCCCCAAGAC
CACGGCACCAACCTCACCTGTCAGGTGCAGTTCCCTGCAGTTGGTGTAATGGTGGAAAGGACCA
TCCAACTCAATGTCACCTGTACCACACAGAACCCAACAAATGGTGTCTGCCTGGAACACAGCAC
AGGGAAACCAGGGACCAGGTCAGGAGTGACTGTAGGCGCCATTGGGGGAGCTGGTGTCACCATG
CTGCTCACTCTCTGCCTCTGCCTTATCTTCTTTCGAGTGAAGACCTGCAGGAAGACAGCATCCC
GGACAGCAGTGGGCATGGACAATATCCACCCAGTTGTGGAGCCAGCTCCCTTGGATTACCAGGA
GTCAGACCTCCCTGATGACCCCACAAGCTCTGCAGAGGTACCCTCCACCTCGGAGATGGAGCAG
GAGCTGTATTATGCCTCCATCAGCTTTCACAGGAGGACGGAGAGCACCTGTGCAGAATACTCAG
AGATCAGGACCCAATGAGGAACCACAAGGAGCATCAGTCTCAGAGGAAGCGTCCATATCCTCCA
GGAAGGGGGATCCAAACCCGATTTTTAGAAGAGTTAACATCCCCATAGGCAACGGGCTTACAAA
CTCCTGAATATGAGTTTCCTGCTATATGAAACTAACTAAGGCTTTGTAATCAGAGAGGCCTGGG
ATGGAATCCATGCTCTCTAATTTATCAGCAGGGTGACTTCATACAAGCCACCTTACCCCTCCGT
GTCTCGGTTTCCTGCTTTGCGAAATGGTTGTAAGAAGTCCCATCTCACAGGGTTGCCATGAGGA
TTAAAAAGAAGTGCATATGGAAAACA

hide sequence

RefSeq Acc Id:

XM_038467334 ⟹ XP_038323262

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	1	105,903,008 - 105,912,671 (-)	NCBI

RefSeq Acc Id:

XM_038528027 ⟹ XP_038383955

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	1	106,339,280 - 106,348,950 (-)	NCBI

RefSeq Acc Id:

XM_038592328 ⟹ XP_038448256

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	1	105,543,870 - 105,553,532 (-)	NCBI

RefSeq Acc Id:

XM_038656126 ⟹ XP_038512054

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	1	106,231,215 - 106,240,879 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005616306	(Get FASTA)	NCBI Sequence Viewer
	XP_038323262	(Get FASTA)	NCBI Sequence Viewer
	XP_038383955	(Get FASTA)	NCBI Sequence Viewer
	XP_038448256	(Get FASTA)	NCBI Sequence Viewer
	XP_038512054	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000041113.1
	ENSCAFP00000062916.1
	ENSCAFP00030005423.1
	ENSCAFP00030005439.1
	ENSCAFP00040014453.1
	ENSCAFP00040014473.1
	ENSCAFP00845020337.1
	ENSCAFP00845020345
	ENSCAFP00845020345.1

RefSeq Acc Id:

XP_005616306 ⟸ XM_005616249

- UniProtKB:

A0A8C0S1J2 (UniProtKB/TrEMBL), A0A8I3NW55 (UniProtKB/TrEMBL), A0A8C0YR14 (UniProtKB/TrEMBL), A0A8I3RY39 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLLLLLPILWAVEWAQGKVKLGASADAGVPRSLAQDPIYWLQIQESLTVQEGLCISVPCYFSYP
MEYWIKTYSALGYWFRNGTNVHWGAPVATNNPDRKVQEETQGQFFLLGDPQANNCSLEIRDAQR
RDSGTYFFRVERGPYLKYSYLQNQLSVHVTALTHTPDILIPGTLESGHPRNLTCSVPWACEQGI
PPIFSWMSAALTSLGPRTHLSSVLTLTPRPQDHGTNLTCQVQFPAVGVMVERTIQLNVTCTTQN
PTNGVCLEHSTGKPGTRSGVTVGAIGGAGVTMLLTLCLCLIFFRVKTCRKTASRTAVGMDNIHP
VVEPAPLDYQESDLPDDPTSSAEVPSTSEMEQELYYASISFHRRTESTCAEYSEIRTQ

hide sequence

RefSeq Acc Id:

XP_038323262 ⟸ XM_038467334

RefSeq Acc Id:

XP_038448256 ⟸ XM_038592328

RefSeq Acc Id:	XP_038512054 ⟸ XM_038656126
- UniProtKB:	A0A8C0S1J2 (UniProtKB/TrEMBL), A0A8I3NW55 (UniProtKB/TrEMBL), A0A8C0YR14 (UniProtKB/TrEMBL), A0A8I3RY39 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038383955 ⟸ XM_038528027
- UniProtKB:	A0A8C0S1J2 (UniProtKB/TrEMBL), A0A8C0YR14 (UniProtKB/TrEMBL), A0A8I3NW55 (UniProtKB/TrEMBL), A0A8I3RY39 (UniProtKB/TrEMBL)

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000028603	UniProtKB/TrEMBL
	ENSCAFG00030003305	UniProtKB/TrEMBL
	ENSCAFG00040008984	UniProtKB/TrEMBL
	ENSCAFG00845014428	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000044048.4	UniProtKB/TrEMBL
	ENSCAFT00000062268.2	UniProtKB/TrEMBL
	ENSCAFT00030006154.1	UniProtKB/TrEMBL
	ENSCAFT00030006178.1	UniProtKB/TrEMBL
	ENSCAFT00040016678.1	UniProtKB/TrEMBL
	ENSCAFT00040016701.1	UniProtKB/TrEMBL
	ENSCAFT00845025812.1	UniProtKB/TrEMBL
	ENSCAFT00845025822	ENTREZGENE
	ENSCAFT00845025822.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
KEGG Report	cfa:100686511	UniProtKB/TrEMBL
NCBI Gene	LOC100686511	ENTREZGENE
PANTHER	SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN	UniProtKB/TrEMBL
	SIALIC ACID-BINDING IG-LIKE LECTIN 9	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A8C0S1J2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0YR14	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3NW55	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RY39	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD