HGFAC (HGF activator) - Rat Genome Database

Name: HGFAC
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: HGFAC (HGF activator) Canis lupus familiaris

Analyze

Symbol:

HGFAC

Name:

HGF activator

RGD ID:

12092636

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); GTPase activator activity (inferred); GTPase regulator activity (inferred); INVOLVED IN blood coagulation (inferred); neuromuscular junction development (inferred); proteolysis (inferred); ASSOCIATED WITH cherubism (ortholog); Crohn's disease (ortholog); Ellis-Van Creveld syndrome (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hepatocyte growth factor activator; HGFA

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HGFAC (HGF activator)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Hgfac (hepatocyte growth factor activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	60,906,839 - 60,916,879 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	60,906,844 - 60,915,280 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	63,557,017 - 63,565,265 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	61,382,412 - 61,390,658 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	61,382,412 - 61,390,658 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	60,874,179 - 60,882,422 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	61,080,281 - 61,088,528 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	61,436,631 - 61,444,882 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cherubism (ISO)

Crohn's disease (ISO)

Ellis-Van Creveld syndrome (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IBA,IEA)

neuromuscular junction development (IEA)

proteolysis (IEA)

regulation of G protein-coupled receptor signaling pathway (IEA)

signal transduction (IEA)

zymogen activation (IBA,IEA)

Cellular Component

cytoplasm (IEA)

extracellular region (IEA)

extracellular space (IBA,IEA)

nucleus (IEA)

plasma membrane (IEA)

rough endoplasmic reticulum (IBA,IEA)

Molecular Function

calcium ion binding (IEA)

GTPase activator activity (IEA)

GTPase regulator activity (IEA)

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

protein kinase binding (IEA)

serine-type endopeptidase activity (IBA,IEA)

serine-type peptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HGFAC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	60,906,839 - 60,916,879 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	60,906,844 - 60,915,280 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	63,557,017 - 63,565,265 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	61,382,412 - 61,390,658 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	61,382,412 - 61,390,658 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	60,874,179 - 60,882,422 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	61,080,281 - 61,088,528 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	61,436,631 - 61,444,882 (-)	NCBI		UU_Cfam_GSD_1.0

HGFAC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	3,441,005 - 3,449,486 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	3,441,968 - 3,449,486 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	3,443,695 - 3,451,213 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	3,413,524 - 3,421,011 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	3,480,694 - 3,488,182	NCBI
Celera	4	3,354,522 - 3,362,009 (+)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	3,380,866 - 3,388,353 (+)	NCBI		HuRef
CHM1_1	4	3,441,294 - 3,448,781 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	3,440,789 - 3,449,270 (+)	NCBI		T2T-CHM13v2.0

Hgfac
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	35,198,853 - 35,205,805 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	35,198,853 - 35,205,805 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	35,041,509 - 35,048,461 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	35,041,509 - 35,048,461 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	35,384,202 - 35,391,085 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	35,358,455 - 35,365,270 (+)	NCBI		MGSCv36	mm8
Celera	5	32,516,343 - 32,523,227 (+)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	17.99	NCBI

Hgfac
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	79,932,219 - 79,938,773 (-)	NCBI		GRCr8
mRatBN7.2	14	75,707,588 - 75,714,182 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	75,707,591 - 75,714,278 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	80,160,640 - 80,167,194 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	81,401,267 - 81,407,821 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	77,846,489 - 77,853,043 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	80,966,902 - 80,973,525 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	80,966,903 - 80,973,456 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	81,655,780 - 81,662,442 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	81,348,282 - 81,354,836 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	81,351,701 - 81,351,935 (-)	NCBI
Celera	14	74,633,495 - 74,640,049 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Hgfac
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	2,155,384 - 2,165,957 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	2,155,924 - 2,161,302 (+)	NCBI	ChiLan1.0	ChiLan1.0

HGFAC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	3,785,510 - 3,793,038 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	3,719,251 - 3,726,711 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	3,590,908 - 3,599,781 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	3,575,819 - 3,583,436 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	3,575,819 - 3,583,436 (+)	Ensembl	panpan1.1		panPan2

Hgfac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	66,587,535 - 66,597,492 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	20,291,852 - 20,298,764 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	20,291,791 - 20,298,764 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HGFAC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	2,077,176 - 2,084,507 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	2,077,164 - 2,084,506 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	1,757,622 - 1,764,975 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HGFAC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	45,283,213 - 45,290,922 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	45,283,206 - 45,290,644 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	1,638,295 - 1,645,982 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hgfac
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	24,483,431 - 24,488,450 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	24,483,358 - 24,488,505 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HGFAC
148 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			6	6		6
Low	2	1	12		5		6		6	4	9	6
Below cutoff	3	4	4		1			6	6	4	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001031815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022415808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY458142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY532633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000023224 ⟹ ENSCAFP00000021566

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	3	60,906,844 - 60,915,280 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000071451 ⟹ ENSCAFP00000064943

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	3	60,906,844 - 60,915,088 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000085040 ⟹ ENSCAFP00000043967

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	3	60,906,844 - 60,914,059 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845019299 ⟹ ENSCAFP00845015085

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	3	61,382,412 - 61,390,658 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845019336 ⟹ ENSCAFP00845015118

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	3	61,382,412 - 61,390,658 (-)	Ensembl

RefSeq Acc Id:

NM_001031815 ⟹ NP_001026985

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	3	60,906,844 - 60,915,088 (-)	NCBI
Dog10K_Boxer_Tasha	3	63,557,017 - 63,565,265 (-)	NCBI
ROS_Cfam_1.0	3	61,382,412 - 61,390,658 (-)	NCBI
UMICH_Zoey_3.1	3	60,874,179 - 60,882,422 (-)	NCBI
UNSW_CanFamBas_1.0	3	61,080,281 - 61,088,528 (-)	NCBI
UU_Cfam_GSD_1.0	3	61,436,631 - 61,444,882 (-)	NCBI

Sequence:

show sequence

AGCCCAGGAGGAGCCATGGGGCGCTGGGCCTGGGGTCCCAGCCTTTGCCCCCTGCCGGGAATGG
CCCTGCTCCTGCTCCTGCTGCTGCTGCTGGTGCCTCACGGGGCTCAGCCCCAGGCTGGTGGGAA
CCTCACAGAACCCCCAGAACCTAACGCCACAGTGACCCCTGGGACCCCCATGATCCCTGTAACC
TCGGTGACCCCTGTGACCCCAGCCACGAGTGCTCCAGAGGCACAGGGACCCCGTGGTAGGGGGC
TCACCCCCCCGCCCAGGGCAGCTCCCTCCAGCAGCAGCCCTGGGGACCCAGTGCTCACAGTGGA
TGGGCAGCCCTGCAGGTTCCCCTTCCGCTATGGCGGCCGCATGCTCCACGCCTGCACTTCAGAA
GGAAGCGCCCACAGGAAGTGGTGTGCCACCACTCACAACTATGACCGCGACAGGGCCTGGGGCT
ACTGTGTGCAGGCTCCGGTGTCCAGGGAGGGCCCAGCTGCCCTGGACTCCTGTGCCTCCAGCCC
CTGCCTCAACGGGGGCTCATGCTCCCACACCCAGGACCCCGGGTCCTACCACTGCACCTGCCCC
ATGGCCTTCACAGGCAGGAACTGCGACACAGAAAAATGCTTTGATGAGACACGCTATGAGCACC
TGGAGGCAGGCGATCGCTGGGCCCGAGTGAGCCAGGGCCAAGTGGAACAGTGTGAGTGTGCTGG
GGGCCAGATCCGCTGCGAGGGCACCCGCCACACAGCTTGCCTGAGCAGTCCGTGCCTGAACGGG
GGCACCTGCCACCTGATCGTGGCCACTGGGACCACCGTGTGCTCCTGCCCGCCGGGCCATGCTG
GGCGACTCTGCAACATTGTGCCCAGCCAGCGCTGCTTCGTGGGGAATGGCACCGAGTATCGAGG
CGTGGCCAGCACGGCGGCCTCGGGGCTCAGCTGTCTGGCCTGGAACTCTGACCTGCTCTACCAG
GAGCTGCACGTGGATTCGGTGGGCGCCGCGGCCCTGCTCGGCCTGGGCCCCCACGCCTACTGCC
GGAACCCTGACAAGGACGAGAGGCCCTGGTGCTACGTGGTCAAGGACAGTGCGCTCTCCTGGGA
GTACTGCCGCCTGGCGGCCTGCGAATCCCTGGCCAGAATTCCATCTCTGACCACTGCGGTCCTG
CTGAGCCAGGCTGAGCCTGCCCCAGTGGGGCGCCAGACCTGTGGCAAGAGGCACAAGAAAAGGA
CCTTCCTACGGCCACGCATCATCGGAGGTTCATCTTCTCTGCCTGGCTCCCACCCCTGGCTGGC
CGCCATCTATATCGGAGACAGCTTCTGTGCAGGGAGTCTTGTCCACACCTGCTGGGTGGTGTCC
GCAGCGCACTGCTTCTCCAATAGCCCCCGCAGGGAAAGTGTCTTAGTGGTCCTAGGCCAACACT
TCTTCAACCAAACAACGGATGTAACACAGACGTTTGGCATCGAGAAGTATATCCCGTACCCCAT
GTACTCAGTGTTCAACCCCAGTGACCATGACCTGGTCTTGATCCGGCTGAAGAAGAAGGGGGAC
CGCTGTGCCATCCGCTCCCAGTTTGTCCAGCCCATCTGCCTGCCTGAGCCCAGCAGCCCCTTCC
CCGCTGGGCACAAGTGCCAAATTGCGGGCTGGGGCCACCAGGATGAGAATGTGAGTGGCTACTC
CAGCTCCCTGCGGGAGGCGCTGGTCCCCCTGGTCGCAGACCACAAGTGCAGCAGCCCTGAGGTG
TACGGAGCAGACATTAGCCCCAACATGCTGTGTGCAGGTTACTTCGACTGCAAGTCTGATGCCT
GCCAGGGGGACTCAGGCGGGCCCCTGGCCTGTGAGAAGAACGGCGTGGCCTACCTATACGGCAT
CATCAGTTGGGGTGACGGCTGTGGGAGGCTTAACAAACCTGGCGTCTATACCCGTGTAGCCAAG
TACGTGGACTGGATCAAAGACCGGATATGGCCCTCTAAACGCCCTTCGGATCCCTCCTGAGACA
GCACCCATCCTTGAGTGGGGCATCCTGCCTCTGCCTCCCCACTATTCCTAGACTCCTAATAATA
AAGATGCTTCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001026985	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAR21859	(Get FASTA)	NCBI Sequence Viewer
	AAS48370	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000021566.2
	ENSCAFP00000043967.1
	ENSCAFP00000064943.1
	ENSCAFP00030003172.1
	ENSCAFP00030003230.1
	ENSCAFP00030003252.1
	ENSCAFP00030003297.1
	ENSCAFP00040005342.1
	ENSCAFP00040005370.1
	ENSCAFP00040005402.1
	ENSCAFP00040005426.1
	ENSCAFP00040005464.1
	ENSCAFP00040005497.1
	ENSCAFP00845015085
	ENSCAFP00845015085.1
	ENSCAFP00845015118.1
GenBank Protein	Q6QNF4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001026985 ⟸ NM_001031815
- Peptide Label:	precursor
- UniProtKB:	Q6QNF4 (UniProtKB/Swiss-Prot), A0A8I3NIY8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRWAWGPSLCPLPGMALLLLLLLLLVPHGAQPQAGGNLTEPPEPNATVTPGTPMIPVTSVTPV TPATSAPEAQGPRGRGLTPPPRAAPSSSSPGDPVLTVDGQPCRFPFRYGGRMLHACTSEGSAHR KWCATTHNYDRDRAWGYCVQAPVSREGPAALDSCASSPCLNGGSCSHTQDPGSYHCTCPMAFTG RNCDTEKCFDETRYEHLEAGDRWARVSQGQVEQCECAGGQIRCEGTRHTACLSSPCLNGGTCHL IVATGTTVCSCPPGHAGRLCNIVPSQRCFVGNGTEYRGVASTAASGLSCLAWNSDLLYQELHVD SVGAAALLGLGPHAYCRNPDKDERPWCYVVKDSALSWEYCRLAACESLARIPSLTTAVLLSQAE PAPVGRQTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCF SNSPRRESVLVVLGQHFFNQTTDVTQTFGIEKYIPYPMYSVFNPSDHDLVLIRLKKKGDRCAIR SQFVQPICLPEPSSPFPAGHKCQIAGWGHQDENVSGYSSSLREALVPLVADHKCSSPEVYGADI SPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLNKPGVYTRVAKYVDWI KDRIWPSKRPSDPS hide sequence

RefSeq Acc Id:

ENSCAFP00000021566 ⟸ ENSCAFT00000023224

RefSeq Acc Id:

ENSCAFP00000043967 ⟸ ENSCAFT00000085040

RefSeq Acc Id:

ENSCAFP00000064943 ⟸ ENSCAFT00000071451

RefSeq Acc Id:

ENSCAFP00845015118 ⟸ ENSCAFT00845019336

RefSeq Acc Id:

ENSCAFP00845015085 ⟸ ENSCAFT00845019299

Protein Domains

EGF-like Fibronectin type-I Fibronectin type-II IRS-type PTB Kringle PDZ Peptidase S1 PH PID RBD RGS

Promoters

RGD ID:

13682797

Promoter ID:

EPDNEW_C867

Type:

initiation region

Name:

HGFAC_1

Description:

HGF activator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	3	60,915,109 - 60,915,169	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000014629	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030001970	UniProtKB/TrEMBL
	ENSCAFG00040003255	UniProtKB/TrEMBL
	ENSCAFG00845010920	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000023224.3	UniProtKB/TrEMBL
	ENSCAFT00000071451.2	UniProtKB/TrEMBL
	ENSCAFT00000085040.2	UniProtKB/TrEMBL
	ENSCAFT00030003581.1	UniProtKB/TrEMBL
	ENSCAFT00030003645.1	UniProtKB/TrEMBL
	ENSCAFT00030003669.1	UniProtKB/TrEMBL
	ENSCAFT00030003717.1	UniProtKB/TrEMBL
	ENSCAFT00040006181.1	UniProtKB/TrEMBL
	ENSCAFT00040006211.1	UniProtKB/TrEMBL
	ENSCAFT00040006248.1	UniProtKB/TrEMBL
	ENSCAFT00040006279.1	UniProtKB/TrEMBL
	ENSCAFT00040006318.1	UniProtKB/TrEMBL
	ENSCAFT00040006354.1	UniProtKB/TrEMBL
	ENSCAFT00845019299	ENTREZGENE
	ENSCAFT00845019299.1	UniProtKB/TrEMBL
	ENSCAFT00845019336.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.167.10	UniProtKB/TrEMBL
	1.10.196.10	UniProtKB/TrEMBL
	2.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
	2.40.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Coagulation_fac_XII/HGFA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dok-7	UniProtKB/TrEMBL
	Dok-7_PH	UniProtKB/TrEMBL
	Dok-7_PTB	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibronectin_type1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN_type2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN_type2_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GoLoco_motif	UniProtKB/TrEMBL
	IRS_PTB	UniProtKB/TrEMBL
	Kringle	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kringle-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kringle_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kringle_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	PTB/PI_dom	UniProtKB/TrEMBL
	RBD_dom	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
	RGS10/12/14-like	UniProtKB/TrEMBL
	RGS12_RGS	UniProtKB/TrEMBL
	RGS_sf	UniProtKB/TrEMBL
	RGS_subdom1/3	UniProtKB/TrEMBL
	RGS_subdomain_2	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/TrEMBL
KEGG Report	cfa:403432	UniProtKB/Swiss-Prot
NCBI Gene	HGFAC	ENTREZGENE
PANTHER	HEPATOCYTE GROWTH FACTOR ACTIVATOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN DOK-7	UniProtKB/TrEMBL
	PTHR21636	UniProtKB/TrEMBL
	REGULATOR OF G-PROTEIN SIGNALING 12	UniProtKB/TrEMBL
	REGULATOR OF G-PROTEIN SIGNALING LOCO	UniProtKB/TrEMBL
	TRYPSIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	fn1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	fn2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GoLoco	UniProtKB/TrEMBL
	IRS	UniProtKB/TrEMBL
	Kringle	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
	RGS12_us1	UniProtKB/TrEMBL
	RGS12_us2	UniProtKB/TrEMBL
	RGS12_usC	UniProtKB/TrEMBL
	Trypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF	Factor_XII_HGFA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FNTYPEII	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KRINGLE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RGSPROTEIN	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GOLOCO	UniProtKB/TrEMBL
	IRS_PTB	UniProtKB/TrEMBL
	KRINGLE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KRINGLE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	PID	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GoLoco	UniProtKB/TrEMBL
	IRS	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PTB	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
	RGS	UniProtKB/TrEMBL
	SM00130	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SSF48097	UniProtKB/TrEMBL
	SSF50156	UniProtKB/TrEMBL
	SSF50494	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54236	UniProtKB/TrEMBL
	SSF57440	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0LXU3_CANLF	UniProtKB/TrEMBL
	A0A8C0M1E2_CANLF	UniProtKB/TrEMBL
	A0A8C0M364_CANLF	UniProtKB/TrEMBL
	A0A8C0PX81_CANLF	UniProtKB/TrEMBL
	A0A8C0PXQ6_CANLF	UniProtKB/TrEMBL
	A0A8C0PXS4_CANLF	UniProtKB/TrEMBL
	A0A8C0PXT3_CANLF	UniProtKB/TrEMBL
	A0A8C0RAM7_CANLF	UniProtKB/TrEMBL
	A0A8C0RWQ7_CANLF	UniProtKB/TrEMBL
	A0A8C0RX15_CANLF	UniProtKB/TrEMBL
	A0A8I3NC74_CANLF	UniProtKB/TrEMBL
	A0A8I3NIY8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NUD0_CANLF	UniProtKB/TrEMBL
	A0A8P0SJ77_CANLF	UniProtKB/TrEMBL
	A0A8P0TGF4_CANLF	UniProtKB/TrEMBL
	HGFA_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID	VGNC:41675	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD