F12 (coagulation factor XII) - Rat Genome Database

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Gene: F12 (coagulation factor XII) Canis lupus familiaris
Analyze
Symbol: F12
Name: coagulation factor XII
RGD ID: 12092157
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN blood coagulation (ortholog); plasma kallikrein-kinin cascade (ortholog); protein processing (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acquired angioedema (ortholog); Acute Coronary Syndrome (ortholog); angioedema (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,950,642 - 35,968,137 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,950,695 - 35,998,025 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBI
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBI
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBI
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBI
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
F12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,950,642 - 35,968,137 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,950,695 - 35,998,025 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBI
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBI
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBI
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBI
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBI
F12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5177,402,141 - 177,409,564 (-)EnsemblGRCh38hg38GRCh38
GRCh385177,402,138 - 177,409,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375176,829,142 - 176,836,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,761,745 - 176,769,183 (-)NCBINCBI36hg18NCBI36
Build 345176,761,746 - 176,769,183NCBI
Celera5171,664,877 - 171,672,315 (+)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5171,749,566 - 171,757,004 (-)NCBIHuRef
CHM1_15176,262,187 - 176,269,625 (-)NCBICHM1_1
F12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,565,771 - 55,574,617 (-)NCBIGRCm39mm39
GRCm39 Ensembl1355,565,771 - 55,574,606 (-)Ensembl
GRCm381355,417,958 - 55,426,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,417,958 - 55,426,793 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,519,327 - 55,528,163 (-)NCBIGRCm37mm9NCBIm37
MGSCv361355,427,610 - 55,436,409 (-)NCBImm8
Celera1356,472,191 - 56,480,813 (-)NCBICelera
Cytogenetic Map13B1NCBI
F12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,207,683 - 9,215,530 (+)NCBI
Rnor_6.0 Ensembl179,736,577 - 9,744,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0179,736,577 - 9,744,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01711,845,561 - 11,853,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,251,611 - 15,259,583 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11715,251,610 - 15,259,583 (+)NCBI
Celera179,286,222 - 9,294,037 (+)NCBICelera
Cytogenetic Map17p14NCBI
F12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,642,096 - 29,650,950 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,644,279 - 29,665,161 (-)NCBIChiLan1.0ChiLan1.0
F12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15179,766,089 - 179,773,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,766,243 - 179,773,485 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05172,703,724 - 172,711,618 (-)NCBIMhudiblu_PPA_v0panPan3
F12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,662,598 - 122,670,021 (-)NCBI
SpeTri2.0NW_0049365971,687,511 - 1,694,782 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,526,767 - 80,546,096 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,527,451 - 80,544,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
F12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,414,074 - 79,438,896 (-)NCBI
ChlSab1.1 Ensembl2379,414,225 - 79,432,298 (-)Ensembl
Vero_WHO_p1.0NW_02366607510,603,660 - 10,619,663 (-)NCBI
F12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473312,666,410 - 12,683,273 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 1 1
Low 5 4 16 6 5 11 8 10 6
Below cutoff 1 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005619160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022417649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038663248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_546206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005324337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005335290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005392620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005392621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005392622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005392623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005425734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005425735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005425736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005425737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000025831   ⟹   ENSCAFP00000023987
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl435,950,695 - 35,998,025 (+)Ensembl
RefSeq Acc Id: XM_005619160   ⟹   XP_005619217
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1435,950,642 - 35,968,137 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022417649   ⟹   XP_022273357
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1435,950,642 - 35,958,592 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038473568   ⟹   XP_038329496
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1436,142,096 - 36,150,033 (+)NCBI
RefSeq Acc Id: XM_038534641   ⟹   XP_038390569
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0436,837,547 - 36,845,486 (+)NCBI
RefSeq Acc Id: XM_038598945   ⟹   XP_038454873
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0436,328,310 - 36,336,250 (+)NCBI
RefSeq Acc Id: XM_038663248   ⟹   XP_038519176
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0436,316,872 - 36,324,811 (+)NCBI
RefSeq Acc Id: XM_546206   ⟹   XP_546206
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1435,950,642 - 35,958,592 (+)NCBI
Dog10K_Boxer_Tasha435,918,068 - 35,926,006 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005324334
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBI
RefSeq Acc Id: XR_005324335
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBI
RefSeq Acc Id: XR_005324336
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBI
RefSeq Acc Id: XR_005324337
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1436,142,096 - 36,150,855 (+)NCBI
RefSeq Acc Id: XR_005335285
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBI
RefSeq Acc Id: XR_005335287
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBI
RefSeq Acc Id: XR_005335288
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBI
RefSeq Acc Id: XR_005335290
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha435,918,068 - 35,926,827 (+)NCBI
RefSeq Acc Id: XR_005358110
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBI
RefSeq Acc Id: XR_005358111
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBI
RefSeq Acc Id: XR_005358112
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBI
RefSeq Acc Id: XR_005358113
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0436,837,547 - 36,846,307 (+)NCBI
RefSeq Acc Id: XR_005392620
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBI
RefSeq Acc Id: XR_005392621
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBI
RefSeq Acc Id: XR_005392622
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBI
RefSeq Acc Id: XR_005392623
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0436,328,310 - 36,337,073 (+)NCBI
RefSeq Acc Id: XR_005425734
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBI
RefSeq Acc Id: XR_005425735
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBI
RefSeq Acc Id: XR_005425736
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBI
RefSeq Acc Id: XR_005425737
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0436,316,872 - 36,325,631 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038329496 (Get FASTA)   NCBI Sequence Viewer  
  XP_038390569 (Get FASTA)   NCBI Sequence Viewer  
  XP_038454873 (Get FASTA)   NCBI Sequence Viewer  
  XP_038519176 (Get FASTA)   NCBI Sequence Viewer  
  XP_546206 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005619217   ⟸   XM_005619160
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_546206   ⟸   XM_546206
- Sequence:
RefSeq Acc Id: XP_022273357   ⟸   XM_022417649
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000023987   ⟸   ENSCAFT00000025831
RefSeq Acc Id: XP_038329496   ⟸   XM_038473568
RefSeq Acc Id: XP_038454873   ⟸   XM_038598945
RefSeq Acc Id: XP_038519176   ⟸   XM_038663248
RefSeq Acc Id: XP_038390569   ⟸   XM_038534641

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016281 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000023987 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025831 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Fibronectin_type1 UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene F12 ENTREZGENE
Pfam EGF UniProtKB/TrEMBL
  fn1 UniProtKB/TrEMBL
  fn2 UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FN1_1 UniProtKB/TrEMBL
  FN2_1 UniProtKB/TrEMBL
  FN2_2 UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FN1 UniProtKB/TrEMBL
  FN2 UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt E2R9D2_CANLF UniProtKB/TrEMBL