SKAP1 (src kinase associated phosphoprotein 1) - Rat Genome Database

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Gene: SKAP1 (src kinase associated phosphoprotein 1) Canis lupus familiaris
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Symbol: SKAP1
Name: src kinase associated phosphoprotein 1
RGD ID: 12091248
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); SH2 domain binding (ortholog); INVOLVED IN positive regulation of cell adhesion (ortholog); protein localization to plasma membrane (ortholog); ASSOCIATED WITH genetic disease (ortholog); Ovarian Neoplasms (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: src kinase-associated phosphoprotein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,412,820 - 24,700,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,412,820 - 24,700,734 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,879,000 - 24,165,316 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,207,000 - 25,495,187 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,207,000 - 25,496,198 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,976,750 - 24,263,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,236,821 - 24,524,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,364,228 - 24,652,057 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SKAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,412,820 - 24,700,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,412,820 - 24,700,734 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,879,000 - 24,165,316 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,207,000 - 25,495,187 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,207,000 - 25,496,198 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,976,750 - 24,263,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,236,821 - 24,524,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,364,228 - 24,652,057 (-)NCBIUU_Cfam_GSD_1.0
SKAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,133,442 - 48,445,061 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,133,442 - 48,430,275 (-)EnsemblGRCh38hg38GRCh38
GRCh371746,210,804 - 46,507,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,565,801 - 43,862,593 (-)NCBINCBI36Build 36hg18NCBI36
Build 341743,565,803 - 43,862,551NCBI
Celera1742,665,165 - 42,961,971 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,580,532 - 41,877,202 (-)NCBIHuRef
CHM1_11746,275,836 - 46,573,375 (-)NCBICHM1_1
T2T-CHM13v2.01748,996,813 - 49,308,533 (-)NCBIT2T-CHM13v2.0
Skap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,355,396 - 96,650,448 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1196,355,419 - 96,649,956 (+)EnsemblGRCm39 Ensembl
GRCm381196,464,570 - 96,759,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,464,593 - 96,759,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,325,905 - 96,620,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,280,714 - 96,575,712 (+)NCBIMGSCv36mm8
Celera11106,114,510 - 106,406,502 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.93NCBI
Skap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,921,961 - 82,229,106 (+)NCBIGRCr8
mRatBN7.21081,425,472 - 81,732,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,425,525 - 81,732,650 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1086,374,269 - 86,680,941 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,872,331 - 86,178,995 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,264,918 - 81,571,595 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01084,309,379 - 84,619,051 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1084,309,430 - 84,619,050 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,110,193 - 84,412,122 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,193,804 - 85,507,161 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,467,411 - 85,521,530 (+)NCBI
Celera1080,191,059 - 80,494,813 (+)NCBICelera
Cytogenetic Map10q26-q31NCBI
Skap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,793,009 - 13,044,922 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,791,633 - 13,043,249 (+)NCBIChiLan1.0ChiLan1.0
SKAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,643,683 - 16,972,403 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,609,292 - 18,938,034 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0179,079,452 - 9,402,192 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,290,859 - 9,585,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,290,929 - 9,581,253 (+)Ensemblpanpan1.1panPan2
Skap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,861,720 - 24,140,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,934,351 - 13,213,465 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,885,443 - 13,213,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1224,374,140 - 24,680,237 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11224,371,699 - 24,680,280 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,146,798 - 24,199,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SKAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,539,842 - 68,851,594 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607739,591,363 - 39,923,289 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Skap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,727,149 - 4,960,082 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,726,715 - 4,960,167 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SKAP1
2588 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 6 5
Low 5 4 15 5 5 6 5 8 10 5
Below cutoff 1 2 1 1 6 2 1

Sequence


RefSeq Acc Id: ENSCAFT00000026653   ⟹   ENSCAFP00000024759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl924,412,820 - 24,700,479 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081471   ⟹   ENSCAFP00000058908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl924,572,288 - 24,700,734 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030041   ⟹   ENSCAFP00845023568
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl925,207,000 - 25,495,129 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030111   ⟹   ENSCAFP00845023617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl925,207,000 - 25,495,129 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030164   ⟹   ENSCAFP00845023656
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl925,366,153 - 25,496,198 (-)Ensembl
RefSeq Acc Id: XM_038485780   ⟹   XP_038341708
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1923,976,750 - 24,263,407 (-)NCBI
RefSeq Acc Id: XM_038547555   ⟹   XP_038403483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0924,364,228 - 24,652,057 (-)NCBI
RefSeq Acc Id: XM_038611532   ⟹   XP_038467460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0924,236,821 - 24,524,016 (-)NCBI
RefSeq Acc Id: XM_038676729   ⟹   XP_038532657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0925,207,000 - 25,495,187 (-)NCBI
RefSeq Acc Id: XM_537665   ⟹   XP_537665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1924,412,820 - 24,700,579 (-)NCBI
Dog10K_Boxer_Tasha923,879,000 - 24,165,316 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005330718
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1923,976,785 - 24,263,407 (-)NCBI
RefSeq Acc Id: XR_005364446
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0924,364,263 - 24,652,057 (-)NCBI
RefSeq Acc Id: XR_005395535
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha923,879,035 - 24,165,316 (-)NCBI
RefSeq Acc Id: XR_005398872
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0924,236,856 - 24,524,016 (-)NCBI
RefSeq Acc Id: XR_005432200
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0925,207,035 - 25,495,187 (-)NCBI
RefSeq Acc Id: XP_537665   ⟸   XM_537665
- UniProtKB: A0A8C0LFC5 (UniProtKB/TrEMBL),   A0A8C0LXF5 (UniProtKB/TrEMBL),   A0A8I3NS32 (UniProtKB/TrEMBL),   A0A8C0M487 (UniProtKB/TrEMBL),   A0A8I3NS72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024759   ⟸   ENSCAFT00000026653
RefSeq Acc Id: ENSCAFP00000058908   ⟸   ENSCAFT00000081471
RefSeq Acc Id: XP_038341708   ⟸   XM_038485780
RefSeq Acc Id: XP_038467460   ⟸   XM_038611532
RefSeq Acc Id: XP_038532657   ⟸   XM_038676729
- UniProtKB: A0A8C0LFC5 (UniProtKB/TrEMBL),   A0A8C0LXF5 (UniProtKB/TrEMBL),   A0A8I3NS32 (UniProtKB/TrEMBL),   A0A8C0M487 (UniProtKB/TrEMBL),   A0A8I3NS72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403483   ⟸   XM_038547555
- UniProtKB: A0A8C0LFC5 (UniProtKB/TrEMBL),   A0A8C0LXF5 (UniProtKB/TrEMBL),   A0A8C0M487 (UniProtKB/TrEMBL),   A0A8I3NS32 (UniProtKB/TrEMBL),   A0A8I3NS72 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845023568   ⟸   ENSCAFT00845030041
RefSeq Acc Id: ENSCAFP00845023617   ⟸   ENSCAFT00845030111
RefSeq Acc Id: ENSCAFP00845023656   ⟸   ENSCAFT00845030164
Protein Domains
PH   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016837 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001951 UniProtKB/TrEMBL
  ENSCAFG00845016959 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026653.6 UniProtKB/TrEMBL
  ENSCAFT00000081471.2 UniProtKB/TrEMBL
  ENSCAFT00000107274.1 UniProtKB/TrEMBL
  ENSCAFT00030003545.1 UniProtKB/TrEMBL
  ENSCAFT00030003562.1 UniProtKB/TrEMBL
  ENSCAFT00845030041 ENTREZGENE
  ENSCAFT00845030041.1 UniProtKB/TrEMBL
  ENSCAFT00845030111.1 UniProtKB/TrEMBL
  ENSCAFT00845030164.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  6.10.250.220 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SKAP1_SH3 UniProtKB/TrEMBL
  SKAP_fam UniProtKB/TrEMBL
KEGG Report cfa:480543 UniProtKB/TrEMBL
NCBI Gene SKAP1 ENTREZGENE
PANTHER PTHR15129 UniProtKB/TrEMBL
  SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 1 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH3DOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8C0LFC5 ENTREZGENE
  A0A8C0LXF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0M487 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NS32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NS72 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P1I6_CANLF UniProtKB/TrEMBL
  A0A8P0TAU9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46196 ENTREZGENE