IL5RA (interleukin 5 receptor subunit alpha) - Rat Genome Database

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Gene: IL5RA (interleukin 5 receptor subunit alpha) Canis lupus familiaris
Analyze
Symbol: IL5RA
Name: interleukin 5 receptor subunit alpha
RGD ID: 12091083
Description: ENCODES a protein that exhibits cytokine receptor activity (inferred); interleukin-5 receptor activity (inferred); INVOLVED IN cellular response to organic substance (ortholog); inflammatory response to antigenic stimulus (ortholog); regulation of interleukin-5 production (ortholog); PARTICIPATES IN interleukin-5 signaling pathway; ASSOCIATED WITH allergic disease (ortholog); asthma (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-5 receptor subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12014,309,805 - 14,349,433 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2014,314,227 - 14,343,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2014,274,082 - 14,309,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02014,340,643 - 14,376,680 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2014,340,517 - 14,375,235 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12014,042,324 - 14,077,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02014,376,619 - 14,412,004 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02014,367,796 - 14,403,236 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IL5RA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12014,309,805 - 14,349,433 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2014,314,227 - 14,343,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2014,274,082 - 14,309,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02014,340,643 - 14,376,680 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2014,340,517 - 14,375,235 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12014,042,324 - 14,077,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02014,376,619 - 14,412,004 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02014,367,796 - 14,403,236 (+)NCBIUU_Cfam_GSD_1.0
IL5RA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3833,066,324 - 3,110,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl33,066,324 - 3,126,613 (-)EnsemblGRCh38hg38GRCh38
GRCh3733,108,008 - 3,152,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3633,086,421 - 3,127,031 (-)NCBINCBI36Build 36hg18NCBI36
Build 3433,106,856 - 3,127,031NCBI
Celera33,050,635 - 3,091,288 (-)NCBICelera
Cytogenetic Map3p26.2NCBI
HuRef33,042,189 - 3,086,251 (-)NCBIHuRef
CHM1_133,057,999 - 3,102,013 (-)NCBICHM1_1
T2T-CHM13v2.033,060,643 - 3,104,729 (-)NCBIT2T-CHM13v2.0
Il5ra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396106,687,336 - 106,725,998 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6106,687,318 - 106,725,998 (-)EnsemblGRCm39 Ensembl
GRCm386106,710,375 - 106,749,037 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6106,710,357 - 106,749,037 (-)EnsemblGRCm38mm10GRCm38
MGSCv376106,660,369 - 106,699,031 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366106,676,152 - 106,714,814 (-)NCBIMGSCv36mm8
Celera6108,526,308 - 108,566,269 (-)NCBICelera
Cytogenetic Map6E1NCBI
cM Map649.19NCBI
Il5ra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84141,186,749 - 141,221,348 (-)NCBIGRCr8
mRatBN7.24139,630,652 - 139,664,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4139,632,066 - 139,668,544 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4145,061,194 - 145,092,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04140,841,888 - 140,872,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04139,485,817 - 139,516,790 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04138,796,165 - 138,834,164 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4138,795,327 - 138,830,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04203,264,446 - 203,298,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44142,067,108 - 142,098,051 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14142,311,948 - 142,342,892 (-)NCBI
Celera4128,345,037 - 128,375,976 (-)NCBICelera
Cytogenetic Map4q41NCBI
Il5ra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542110,221,694 - 10,259,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542110,211,594 - 10,259,760 (+)NCBIChiLan1.0ChiLan1.0
IL5RA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v223,063,000 - 3,103,991 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan133,067,759 - 3,132,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v033,009,780 - 3,051,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.133,112,355 - 3,156,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl33,112,355 - 3,156,282 (-)Ensemblpanpan1.1panPan2
Il5ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049429,821,165 - 9,841,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365772,776,721 - 2,797,300 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365772,776,608 - 2,797,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5RA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1359,652,271 - 59,690,176 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11359,651,184 - 59,692,211 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21365,950,136 - 65,987,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5RA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12239,156,711 - 39,199,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2239,158,023 - 39,192,861 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041127,504,673 - 127,547,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5ra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477313,311,583 - 13,347,315 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477313,309,888 - 13,347,318 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL5RA
603 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 8 1
Below cutoff 3 2 16 4 6 4 5 2 9 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000009673   ⟹   ENSCAFP00000008981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2014,314,227 - 14,343,793 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000038503   ⟹   ENSCAFP00000034236
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2014,314,227 - 14,343,793 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022452   ⟹   ENSCAFP00845017635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2014,340,517 - 14,375,235 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845022467   ⟹   ENSCAFP00845017644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2014,340,517 - 14,375,235 (+)Ensembl
RefSeq Acc Id: XM_022407196   ⟹   XP_022262904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12014,309,805 - 14,349,433 (+)NCBI
Dog10K_Boxer_Tasha2014,274,082 - 14,309,507 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038427117   ⟹   XP_038283045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02014,340,643 - 14,376,680 (+)NCBI
RefSeq Acc Id: XM_038502887   ⟹   XP_038358815
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12014,042,324 - 14,077,731 (+)NCBI
RefSeq Acc Id: XM_038565824   ⟹   XP_038421752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02014,367,796 - 14,403,236 (+)NCBI
RefSeq Acc Id: XM_038629948   ⟹   XP_038485876
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02014,376,619 - 14,412,004 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022262904   ⟸   XM_022407196
- UniProtKB: A0A8C0RYQ0 (UniProtKB/TrEMBL),   A0A8P0N8T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000034236   ⟸   ENSCAFT00000038503
RefSeq Acc Id: ENSCAFP00000008981   ⟸   ENSCAFT00000009673
RefSeq Acc Id: XP_038358815   ⟸   XM_038502887
RefSeq Acc Id: XP_038485876   ⟸   XM_038629948
RefSeq Acc Id: XP_038283045   ⟸   XM_038427117
- UniProtKB: A0A8I3RX48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038421752   ⟸   XM_038565824
- UniProtKB: A0A8C0RYQ0 (UniProtKB/TrEMBL),   A0A8P0N8T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017644   ⟸   ENSCAFT00845022467
RefSeq Acc Id: ENSCAFP00845017635   ⟸   ENSCAFT00845022452
Protein Domains
Fibronectin type-III


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005991 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013852 UniProtKB/TrEMBL
  ENSCAFG00040005920 UniProtKB/TrEMBL
  ENSCAFG00845012603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000009673.5 UniProtKB/TrEMBL
  ENSCAFT00000038503.5 UniProtKB/TrEMBL
  ENSCAFT00030025741.1 UniProtKB/TrEMBL
  ENSCAFT00030025789.1 UniProtKB/TrEMBL
  ENSCAFT00040011087.1 UniProtKB/TrEMBL
  ENSCAFT00040011110.1 UniProtKB/TrEMBL
  ENSCAFT00845022452 ENTREZGENE
  ENSCAFT00845022452.1 UniProtKB/TrEMBL
  ENSCAFT00845022467.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Short_hematopoietin_rcpt_2_CS UniProtKB/TrEMBL
  TypeI_recpt_CBD UniProtKB/TrEMBL
NCBI Gene IL5RA ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-21 RECEPTOR UniProtKB/TrEMBL
Pfam IL6Ra-bind UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt A0A8C0N7C6_CANLF UniProtKB/TrEMBL
  A0A8C0RYQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NXY4_CANLF UniProtKB/TrEMBL
  A0A8I3RX48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N8T5 ENTREZGENE
UniProt Secondary A0A8P0N8T5 UniProtKB/TrEMBL
  A0A8P0NMR6 UniProtKB/TrEMBL
VGNC ID VGNC:41991 ENTREZGENE