DVL3 (dishevelled segment polarity protein 3) - Rat Genome Database

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Gene: DVL3 (dishevelled segment polarity protein 3) Canis lupus familiaris
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Symbol: DVL3
Name: dishevelled segment polarity protein 3
RGD ID: 12090940
Description: ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN cochlea morphogenesis (ortholog); heart morphogenesis (ortholog); non-canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH autosomal dominant Robinow syndrome 1 (ortholog); autosomal dominant Robinow syndrome 2 (ortholog); autosomal dominant Robinow syndrome 3 (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dishevelled, dsh homolog 3; segment polarity protein dishevelled homolog DVL-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,053,534 - 17,069,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,053,343 - 17,068,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,140,844 - 21,154,943 (+)NCBI
ROS_Cfam_1.03416,961,718 - 16,975,817 (+)NCBI
UMICH_Zoey_3.13416,999,057 - 17,013,143 (+)NCBI
UNSW_CanFamBas_1.03416,995,018 - 17,011,464 (+)NCBI
UU_Cfam_GSD_1.03417,225,218 - 17,241,675 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
DVL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,053,534 - 17,069,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,053,343 - 17,068,389 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,140,844 - 21,154,943 (+)NCBI
ROS_Cfam_1.03416,961,718 - 16,975,817 (+)NCBI
UMICH_Zoey_3.13416,999,057 - 17,013,143 (+)NCBI
UNSW_CanFamBas_1.03416,995,018 - 17,011,464 (+)NCBI
UU_Cfam_GSD_1.03417,225,218 - 17,241,675 (+)NCBI
DVL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3184,155,377 - 184,173,614 (+)EnsemblGRCh38hg38GRCh38
GRCh383184,155,377 - 184,173,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,873,165 - 183,891,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,355,978 - 185,374,008 (+)NCBINCBI36hg18NCBI36
Build 343185,355,985 - 185,374,016NCBI
Celera3182,315,580 - 182,333,025 (+)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,280,976 - 181,298,206 (+)NCBIHuRef
CHM1_13183,837,689 - 183,855,719 (+)NCBICHM1_1
Dvl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,335,694 - 20,352,763 (+)NCBIGRCm39mm39
GRCm39 Ensembl1620,335,732 - 20,352,760 (+)Ensembl
GRCm381620,516,949 - 20,534,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,516,982 - 20,534,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,517,137 - 20,532,260 (+)NCBIGRCm37mm9NCBIm37
MGSCv361620,430,525 - 20,445,193 (+)NCBImm8
Celera1621,081,348 - 21,096,276 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.46NCBI
Dvl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,365,446 - 80,382,641 (-)NCBI
Rnor_6.0 Ensembl1184,051,078 - 84,068,302 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01184,051,177 - 84,068,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01187,123,483 - 87,139,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,597,654 - 82,622,175 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11182,654,389 - 82,679,764 (-)NCBI
Celera1179,207,145 - 79,222,292 (-)NCBICelera
Cytogenetic Map11q23NCBI
Dvl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,293,222 - 23,301,694 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,291,650 - 23,301,695 (-)NCBIChiLan1.0ChiLan1.0
DVL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13189,674,405 - 189,691,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,674,399 - 189,693,130 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03181,190,961 - 181,207,831 (+)NCBIMhudiblu_PPA_v0panPan3
Dvl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,602,013 - 119,618,283 (-)NCBI
SpeTri2.0NW_0049365785,693,433 - 5,710,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DVL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,076,003 - 122,092,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,075,851 - 122,092,975 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,521,353 - 131,532,563 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DVL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,254,764 - 5,270,661 (-)NCBI
ChlSab1.1 Ensembl155,254,661 - 5,270,403 (-)Ensembl
Vero_WHO_p1.0NW_02366606314,033,307 - 14,049,218 (-)NCBI
Dvl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,396,437 - 72,412,260 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 21 5 6 5 6 6 12 8 10 6
Low 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019400   ⟹   ENSCAFP00000017997
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3417,053,343 - 17,068,389 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000047567   ⟹   ENSCAFP00000042156
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3417,053,343 - 17,067,641 (+)Ensembl
RefSeq Acc Id: XM_014110434   ⟹   XP_013965909
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13417,053,534 - 17,069,965 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038445695   ⟹   XP_038301623
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03416,961,718 - 16,975,817 (+)NCBI
RefSeq Acc Id: XM_038519884   ⟹   XP_038375812
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13416,999,057 - 17,013,143 (+)NCBI
RefSeq Acc Id: XM_038583521   ⟹   XP_038439449
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03417,225,218 - 17,241,675 (+)NCBI
RefSeq Acc Id: XM_038583522   ⟹   XP_038439450
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03417,225,218 - 17,239,316 (+)NCBI
RefSeq Acc Id: XM_038647928   ⟹   XP_038503856
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03416,995,018 - 17,011,464 (+)NCBI
RefSeq Acc Id: XM_038647929   ⟹   XP_038503857
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03416,995,018 - 17,009,111 (+)NCBI
RefSeq Acc Id: XM_535822   ⟹   XP_535822
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13417,053,535 - 17,067,642 (+)NCBI
Dog10K_Boxer_Tasha3421,140,844 - 21,154,943 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_535822   ⟸   XM_535822
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013965909   ⟸   XM_014110434
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000017997   ⟸   ENSCAFT00000019400
RefSeq Acc Id: ENSCAFP00000042156   ⟸   ENSCAFT00000047567
RefSeq Acc Id: XP_038375812   ⟸   XM_038519884
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038503856   ⟸   XM_038647928
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038503857   ⟸   XM_038647929
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038301623   ⟸   XM_038445695
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038439449   ⟸   XM_038583521
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038439450   ⟸   XM_038583522
- Peptide Label: isoform X1

Promoters
RGD ID:13688891
Promoter ID:EPDNEW_C6959
Type:initiation region
Name:DVL3_1
Description:dishevelled segment polarity protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C6960  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13417,053,390 - 17,053,450EPDNEW
RGD ID:13688892
Promoter ID:EPDNEW_C6960
Type:multiple initiation site
Name:DVL3_2
Description:dishevelled segment polarity protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C6959  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13417,053,571 - 17,053,631EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012180 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000017997 UniProtKB/TrEMBL
  ENSCAFP00000042156 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019400 UniProtKB/TrEMBL
  ENSCAFT00000047567 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  3.10.20.380 UniProtKB/TrEMBL
InterPro DEP_dom UniProtKB/TrEMBL
  Dishevelled_C-dom UniProtKB/TrEMBL
  Dishevelled_fam UniProtKB/TrEMBL
  Dishevelled_protein_dom UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/TrEMBL
  Dsh/Dvl-rel UniProtKB/TrEMBL
  DVL3 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report cfa:478650 UniProtKB/TrEMBL
NCBI Gene DVL3 ENTREZGENE
PANTHER PTHR10878 UniProtKB/TrEMBL
  PTHR10878:SF6 UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  Dishevelled UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  Dsh_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PRINTS DISHEVELLED UniProtKB/TrEMBL
  DISHEVELLED3 UniProtKB/TrEMBL
PROSITE DEP UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
SMART DAX UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt F1PIB1_CANLF UniProtKB/TrEMBL
  J9P8S5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40139 ENTREZGENE