ISCU (iron-sulfur cluster assembly enzyme) - Rat Genome Database

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Gene: ISCU (iron-sulfur cluster assembly enzyme) Canis lupus familiaris
Analyze
Symbol: ISCU
Name: iron-sulfur cluster assembly enzyme
RGD ID: 12086610
Description: ENCODES a protein that exhibits iron-sulfur cluster chaperone activity (ortholog); molecular adaptor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN [2Fe-2S] cluster assembly (ortholog); [4Fe-4S] cluster assembly (ortholog); negative regulation of iron ion import across plasma membrane (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); genetic disease (ortholog); myopathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: iron-sulfur cluster assembly enzyme ISCU, mitochondrial; iron-sulfur cluster scaffold homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,300,800 - 18,307,668 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,300,803 - 18,307,652 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2617,492,198 - 17,499,090 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02618,647,123 - 18,654,012 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,647,126 - 18,653,991 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,701,195 - 17,708,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,638,137 - 18,645,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,656,527 - 18,663,400 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ISCU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,300,800 - 18,307,668 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,300,803 - 18,307,652 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2617,492,198 - 17,499,090 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02618,647,123 - 18,654,012 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,647,126 - 18,653,991 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,701,195 - 17,708,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,638,137 - 18,645,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,656,527 - 18,663,400 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ISCU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,561,463 - 108,569,384 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,562,582 - 108,569,368 (+)Ensemblhg38GRCh38
GRCh3712108,955,239 - 108,963,160 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,480,512 - 107,487,273 (+)NCBIBuild 36Build 36hg18NCBI36
Celera12108,625,685 - 108,632,553 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12106,020,849 - 106,027,716 (+)NCBIHuRef
CHM1_112108,922,512 - 108,929,380 (+)NCBICHM1_1
T2T-CHM13v2.012108,530,831 - 108,538,753 (+)NCBIT2T-CHM13v2.0
Iscu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,910,479 - 113,916,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,910,809 - 113,916,349 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385113,772,418 - 113,778,288 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,772,748 - 113,778,288 (+)Ensemblmm10GRCm38
MGSCv375114,222,821 - 114,228,291 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365114,033,811 - 114,039,281 (+)NCBIMGSCv36mm8
Celera5110,873,936 - 110,879,406 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
Iscu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,512,852 - 48,518,696 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1248,512,852 - 48,518,696 (-)EnsemblGRCr8
mRatBN7.21242,852,305 - 42,858,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,852,305 - 42,858,150 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1244,018,678 - 44,024,102 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,632,273 - 44,637,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,692,805 - 43,698,229 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,621,454 - 48,627,297 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,621,454 - 48,627,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01250,403,338 - 50,409,181 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,886,419 - 43,892,329 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1244,453,913 - 44,459,757 (-)NCBICelera
RGSC_v3.11243,749,819 - 43,755,677 (-)NCBI
Cytogenetic Map12q16NCBI
Iscu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,833,924 - 9,841,619 (+)Ensembl
ChiLan1.0NW_0049554559,833,924 - 9,840,547 (+)NCBIChiLan1.0ChiLan1.0
ISCU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,622,727 - 116,629,492 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,619,125 - 116,625,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,132,987 - 106,140,879 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,529,162 - 109,537,053 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,529,162 - 109,537,053 (+)EnsemblpanPan2panpan1.1
Iscu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,977,307 - 144,983,670 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936769491,530 - 498,692 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936769492,024 - 498,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISCU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,216,111 - 42,222,711 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11442,216,103 - 42,222,570 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,761,391 - 44,767,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISCU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111103,753,175 - 103,760,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11103,753,189 - 103,760,364 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037141,335,350 - 141,342,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iscu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474711,808,640 - 11,816,400 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474711,808,789 - 11,815,269 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in ISCU
129 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000018004   ⟹   ENSCAFP00000016673
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,300,859 - 18,307,641 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000063584   ⟹   ENSCAFP00000047520
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,300,803 - 18,306,660 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000067814   ⟹   ENSCAFP00000062959
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,302,381 - 18,307,652 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000089796   ⟹   ENSCAFP00000050125
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,302,772 - 18,307,652 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047100   ⟹   ENSCAFP00845036964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,647,126 - 18,652,614 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047159   ⟹   ENSCAFP00845037007
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,647,182 - 18,653,980 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047211   ⟹   ENSCAFP00845037052
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,648,704 - 18,653,991 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845047265   ⟹   ENSCAFP00845037096
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,649,095 - 18,653,991 (-)Ensembl
RefSeq Acc Id: XM_038437037   ⟹   XP_038292965
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02618,647,123 - 18,654,012 (-)NCBI
RefSeq Acc Id: XM_038511861   ⟹   XP_038367789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12617,701,195 - 17,708,096 (+)NCBI
RefSeq Acc Id: XM_038575445   ⟹   XP_038431373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02618,656,527 - 18,663,400 (-)NCBI
RefSeq Acc Id: XM_038639627   ⟹   XP_038495555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02618,638,137 - 18,645,016 (-)NCBI
RefSeq Acc Id: XM_534722   ⟹   XP_534722
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12618,300,800 - 18,307,668 (-)NCBI
Dog10K_Boxer_Tasha2617,492,198 - 17,499,090 (+)NCBI
Sequence:
RefSeq Acc Id: XP_534722   ⟸   XM_534722
- UniProtKB: A0A8C0PS73 (UniProtKB/TrEMBL),   A0A8I3PX30 (UniProtKB/TrEMBL),   A0A8C0PIG2 (UniProtKB/TrEMBL),   A0A8C0TFE0 (UniProtKB/TrEMBL),   A0A8I3PZQ7 (UniProtKB/TrEMBL),   A0A8I3SAD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000062959   ⟸   ENSCAFT00000067814
Ensembl Acc Id: ENSCAFP00000047520   ⟸   ENSCAFT00000063584
Ensembl Acc Id: ENSCAFP00000016673   ⟸   ENSCAFT00000018004
Ensembl Acc Id: ENSCAFP00000050125   ⟸   ENSCAFT00000089796
RefSeq Acc Id: XP_038367789   ⟸   XM_038511861
RefSeq Acc Id: XP_038495555   ⟸   XM_038639627
RefSeq Acc Id: XP_038292965   ⟸   XM_038437037
- UniProtKB: A0A8C0PS73 (UniProtKB/TrEMBL),   A0A8I3PX30 (UniProtKB/TrEMBL),   A0A8C0PIG2 (UniProtKB/TrEMBL),   A0A8C0TFE0 (UniProtKB/TrEMBL),   A0A8I3PZQ7 (UniProtKB/TrEMBL),   A0A8I3SAD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431373   ⟸   XM_038575445
- UniProtKB: A0A8C0PIG2 (UniProtKB/TrEMBL),   A0A8C0PS73 (UniProtKB/TrEMBL),   A0A8C0TFE0 (UniProtKB/TrEMBL),   A0A8I3PX30 (UniProtKB/TrEMBL),   A0A8I3PZQ7 (UniProtKB/TrEMBL),   A0A8I3SAD9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845037007   ⟸   ENSCAFT00845047159
Ensembl Acc Id: ENSCAFP00845037096   ⟸   ENSCAFT00845047265
Ensembl Acc Id: ENSCAFP00845036964   ⟸   ENSCAFT00845047100
Ensembl Acc Id: ENSCAFP00845037052   ⟸   ENSCAFT00845047211
Protein Domains
NIF system FeS cluster assembly NifU N-terminal

Promoters
RGD ID:13687952
Promoter ID:EPDNEW_C6019
Type:multiple initiation site
Name:ISCU_1
Description:iron-sulfur cluster assembly enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12618,307,636 - 18,307,696EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011324 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030026154 UniProtKB/TrEMBL
  ENSCAFG00040021484 UniProtKB/TrEMBL
  ENSCAFG00845026711 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018004.5 UniProtKB/TrEMBL
  ENSCAFT00000063584.2 UniProtKB/TrEMBL
  ENSCAFT00000067814.2 UniProtKB/TrEMBL
  ENSCAFT00000089796.2 UniProtKB/TrEMBL
  ENSCAFT00030048386.1 UniProtKB/TrEMBL
  ENSCAFT00030048387.1 UniProtKB/TrEMBL
  ENSCAFT00030048388.1 UniProtKB/TrEMBL
  ENSCAFT00030048389.1 UniProtKB/TrEMBL
  ENSCAFT00040039921.1 UniProtKB/TrEMBL
  ENSCAFT00040039958.1 UniProtKB/TrEMBL
  ENSCAFT00040039998.1 UniProtKB/TrEMBL
  ENSCAFT00040040050.1 UniProtKB/TrEMBL
  ENSCAFT00845047100.1 UniProtKB/TrEMBL
  ENSCAFT00845047159 ENTREZGENE
  ENSCAFT00845047159.1 UniProtKB/TrEMBL
  ENSCAFT00845047211.1 UniProtKB/TrEMBL
  ENSCAFT00845047265.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1010.10 UniProtKB/TrEMBL
InterPro ISC_FeS_clus_asmbl_IscU UniProtKB/TrEMBL
  NIF_FeS_clus_asmbl_NifU_N UniProtKB/TrEMBL
KEGG Report cfa:477527 UniProtKB/TrEMBL
NCBI Gene ISCU ENTREZGENE
PANTHER PTHR10093 UniProtKB/TrEMBL
Pfam NifU_N UniProtKB/TrEMBL
Superfamily-SCOP SufE/NifU UniProtKB/TrEMBL
UniProt A0A8C0PIG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PS73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TC72_CANLF UniProtKB/TrEMBL
  A0A8C0TFE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PX30 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PZQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3SAB7_CANLF UniProtKB/TrEMBL
  A0A8I3SAD9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42105 ENTREZGENE