MYOD1 (myogenic differentiation 1) - Rat Genome Database

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Gene: MYOD1 (myogenic differentiation 1) Canis lupus familiaris
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Symbol: MYOD1
Name: myogenic differentiation 1
RGD ID: 12084207
Description: ENCODES a protein that exhibits DNA binding (ortholog); E-box binding (ortholog); INVOLVED IN cellular response to glucocorticoid stimulus (ortholog); cellular response to oxygen levels (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH autosomal dominant centronuclear myopathy (ortholog); congenital diaphragmatic hernia (ortholog); congenital myopathy 17 (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myoblast determination protein 1; MYOD
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,257,792 - 40,260,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,258,027 - 40,259,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,757,431 - 39,759,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,362,253 - 41,364,156 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,362,471 - 41,364,912 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,375,120 - 40,377,023 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,582,881 - 40,584,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,921,445 - 40,923,349 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cellular response to estradiol stimulus  (IEA)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to oxygen levels  (IEA,ISO)
cellular response to starvation  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
muscle cell differentiation  (IEA)
muscle organ development  (IEA,ISO)
myoblast differentiation  (IEA,ISO)
myoblast fate determination  (IEA,ISO)
myoblast fusion  (IEA,ISO)
myotube cell development  (IEA)
myotube differentiation  (IEA,ISO)
myotube differentiation involved in skeletal muscle regeneration  (IEA,ISO)
negative regulation of myoblast proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of muscle cell differentiation  (IEA)
positive regulation of myoblast fusion  (IEA)
positive regulation of skeletal muscle tissue regeneration  (IEA,ISO)
positive regulation of snRNA transcription by RNA polymerase II  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of alternative mRNA splicing, via spliceosome  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of RNA splicing  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to muscle stretch  (ISO)
skeletal muscle atrophy  (ISO)
skeletal muscle cell differentiation  (IEA,ISO)
skeletal muscle fiber adaptation  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
striated muscle cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:25403511   PMID:30032202  


Genomics

Comparative Map Data
MYOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,257,792 - 40,260,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,258,027 - 40,259,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,757,431 - 39,759,334 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,362,253 - 41,364,156 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,362,471 - 41,364,912 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,375,120 - 40,377,023 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,582,881 - 40,584,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,921,445 - 40,923,349 (+)NCBIUU_Cfam_GSD_1.0
MYOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,719,571 - 17,722,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,719,571 - 17,722,136 (+)EnsemblGRCh38hg38GRCh38
GRCh371117,741,118 - 17,743,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,697,686 - 17,700,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 341117,697,734 - 17,700,254NCBI
Celera1117,873,623 - 17,876,191 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,425,110 - 17,427,678 (+)NCBIHuRef
CHM1_11117,740,837 - 17,743,405 (+)NCBICHM1_1
T2T-CHM13v2.01117,817,261 - 17,819,826 (+)NCBIT2T-CHM13v2.0
Myod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,025,898 - 46,028,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,025,898 - 46,028,523 (+)EnsemblGRCm39 Ensembl
GRCm38746,376,474 - 46,379,092 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,376,474 - 46,379,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv37753,631,844 - 53,634,462 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,244,524 - 46,247,137 (+)NCBIMGSCv36mm8
Celera741,849,969 - 41,852,587 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.03NCBI
Myod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,021,161 - 106,023,871 (+)NCBIGRCr8
mRatBN7.2196,884,864 - 96,887,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,884,948 - 96,887,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,270,899 - 102,273,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,742,884 - 110,745,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,033,260 - 104,035,970 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,396,538 - 102,399,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,396,538 - 102,399,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,481,604 - 103,484,314 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,910,190 - 96,912,900 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,988,300 - 96,991,011 (+)NCBI
Celera191,133,211 - 91,135,921 (+)NCBICelera
Cytogenetic Map1q22NCBI
Myod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,523,924 - 32,526,674 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,523,959 - 32,526,575 (+)NCBIChiLan1.0ChiLan1.0
MYOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,051,315 - 20,053,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,011,813 - 20,014,376 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,772,317 - 17,774,884 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,456,124 - 17,458,690 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,456,124 - 17,458,690 (+)Ensemblpanpan1.1panPan2
Myod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,372,988 - 45,375,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,407,661 - 1,409,573 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,407,187 - 1,409,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,415,775 - 41,424,435 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,422,522 - 41,424,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,483,015 - 44,484,730 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103239432
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,250,927 - 47,254,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,251,551 - 47,253,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038144,644,005 - 144,646,580 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,345,613 - 9,347,326 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,345,390 - 9,347,985 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYOD1
39 total Variants

Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
mesenchyme
mesoderm
nervous system
reproductive system
1 15 9 10 10 12 14

Sequence


Ensembl Acc Id: ENSCAFT00000014416   ⟹   ENSCAFP00000013332
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2140,258,027 - 40,259,712 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845026712   ⟹   ENSCAFP00845021049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2141,362,471 - 41,364,912 (+)Ensembl
RefSeq Acc Id: XM_038429609   ⟹   XP_038285537
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02141,362,253 - 41,364,156 (+)NCBI
RefSeq Acc Id: XM_038506186   ⟹   XP_038362114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12140,375,120 - 40,377,023 (+)NCBI
RefSeq Acc Id: XM_038568190   ⟹   XP_038424118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02140,921,445 - 40,923,349 (+)NCBI
RefSeq Acc Id: XM_038632290   ⟹   XP_038488218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02140,582,881 - 40,584,784 (+)NCBI
RefSeq Acc Id: XM_849663   ⟹   XP_854756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12140,257,792 - 40,260,461 (+)NCBI
Dog10K_Boxer_Tasha2139,757,431 - 39,759,334 (+)NCBI
Sequence:
RefSeq Acc Id: XP_854756   ⟸   XM_849663
- UniProtKB: A0A8C0TH61 (UniProtKB/TrEMBL),   A0A8C0KWK8 (UniProtKB/TrEMBL),   A0A8I3NJT4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000013332   ⟸   ENSCAFT00000014416
RefSeq Acc Id: XP_038362114   ⟸   XM_038506186
RefSeq Acc Id: XP_038488218   ⟸   XM_038632290
RefSeq Acc Id: XP_038285537   ⟸   XM_038429609
- UniProtKB: A0A8C0TH61 (UniProtKB/TrEMBL),   A0A8C0KWK8 (UniProtKB/TrEMBL),   A0A8I3NJT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038424118   ⟸   XM_038568190
- UniProtKB: A0A8C0KWK8 (UniProtKB/TrEMBL),   A0A8C0TH61 (UniProtKB/TrEMBL),   A0A8I3NJT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845021049   ⟸   ENSCAFT00845026712
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009066 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024241 UniProtKB/TrEMBL
  ENSCAFG00040022928 UniProtKB/TrEMBL
  ENSCAFG00845014938 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014416.4 UniProtKB/TrEMBL
  ENSCAFT00030044572.1 UniProtKB/TrEMBL
  ENSCAFT00040042627.1 UniProtKB/TrEMBL
  ENSCAFT00845026712 ENTREZGENE
  ENSCAFT00845026712.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Myf5 UniProtKB/TrEMBL
  MyoD_N UniProtKB/TrEMBL
  Myogenic_factor UniProtKB/TrEMBL
KEGG Report cfa:611940 UniProtKB/TrEMBL
NCBI Gene MYOD1 ENTREZGENE
PANTHER MYOBLAST DETERMINATION PROTEIN 1 UniProtKB/TrEMBL
  PTHR11534 UniProtKB/TrEMBL
Pfam Basic UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
  Myf5 UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART BASIC UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A8C0KWK8 ENTREZGENE
  A0A8C0TH61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NJT4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43578 ENTREZGENE