ESAM (endothelial cell adhesion molecule) - Rat Genome Database

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Gene: ESAM (endothelial cell adhesion molecule) Canis lupus familiaris
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Symbol: ESAM
Name: endothelial cell adhesion molecule
RGD ID: 12082309
Description: ENCODES a protein that exhibits cell-cell adhesion mediator activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); homophilic cell adhesion via plasma membrane adhesion molecules (ortholog); ASSOCIATED WITH Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); genetic disease (ortholog); FOUND IN adherens junction (inferred); bicellular tight junction (inferred); cell-cell junction (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endothelial cell-selective adhesion molecule
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,658,920 - 9,667,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,658,937 - 9,667,141 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha59,703,800 - 9,712,017 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.059,598,546 - 9,606,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl59,598,562 - 9,606,762 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.159,670,739 - 9,678,936 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.059,641,129 - 9,649,324 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,677,654 - 9,685,860 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ESAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,658,920 - 9,667,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,658,937 - 9,667,141 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha59,703,800 - 9,712,017 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.059,598,546 - 9,606,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl59,598,562 - 9,606,762 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.159,670,739 - 9,678,936 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.059,641,129 - 9,649,324 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,677,654 - 9,685,860 (+)NCBIUU_Cfam_GSD_1.0
ESAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811124,753,126 - 124,762,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11124,752,583 - 124,762,290 (-)EnsemblGRCh38hg38GRCh38
GRCh3711124,623,022 - 124,632,186 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,128,229 - 124,137,433 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411124,128,241 - 124,137,385NCBI
Celera11121,783,196 - 121,792,400 (-)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11120,565,472 - 120,574,614 (-)NCBIHuRef
CHM1_111124,509,116 - 124,518,320 (-)NCBICHM1_1
T2T-CHM13v2.011124,781,790 - 124,790,954 (-)NCBIT2T-CHM13v2.0
Esam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,439,385 - 37,449,615 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,439,374 - 37,449,615 (+)EnsemblGRCm39 Ensembl
GRCm38937,528,089 - 37,538,319 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,528,078 - 37,538,319 (+)EnsemblGRCm38mm10GRCm38
MGSCv37937,335,674 - 37,345,904 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36937,263,004 - 37,287,987 (+)NCBIMGSCv36mm8
Celera934,745,238 - 34,755,449 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.77NCBI
Esam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,426,985 - 45,437,976 (+)NCBIGRCr8
mRatBN7.2837,238,228 - 37,249,217 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,238,287 - 37,249,215 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx841,254,688 - 41,265,679 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0839,537,741 - 39,548,734 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0837,400,661 - 37,411,652 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0839,997,875 - 40,008,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,997,875 - 40,008,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0839,998,699 - 40,009,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,773,224 - 38,784,349 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,781,989 - 38,793,113 (+)NCBI
Celera837,205,957 - 37,216,885 (-)NCBICelera
Cytogenetic Map8q22NCBI
ESAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29125,448,572 - 125,457,765 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111126,553,459 - 126,562,632 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011119,580,140 - 119,589,338 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111123,495,773 - 123,504,938 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11123,495,779 - 123,504,938 (-)Ensemblpanpan1.1panPan2
Esam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947106,957,212 - 106,966,360 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,203,400 - 1,213,975 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367431,204,536 - 1,213,918 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl951,983,023 - 51,992,393 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1951,983,019 - 51,992,415 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2957,498,520 - 57,507,920 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ESAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,901,705 - 115,911,100 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,900,499 - 115,911,660 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604310,207,913 - 10,216,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ESAM
115 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 5 10 2 5 2 5 6 7 10 6
Low 2 12 4 1 4 1 5 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000017725   ⟹   ENSCAFP00000016408
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl59,658,937 - 9,667,141 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845021385   ⟹   ENSCAFP00845016811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl59,598,562 - 9,606,762 (+)Ensembl
RefSeq Acc Id: XM_005619618   ⟹   XP_005619675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.159,659,158 - 9,667,134 (+)NCBI
Dog10K_Boxer_Tasha59,704,687 - 9,712,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038474680   ⟹   XP_038330608
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.159,670,739 - 9,678,936 (+)NCBI
RefSeq Acc Id: XM_038535810   ⟹   XP_038391738
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.059,677,654 - 9,685,860 (+)NCBI
RefSeq Acc Id: XM_038535811   ⟹   XP_038391739
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.059,678,544 - 9,685,860 (+)NCBI
RefSeq Acc Id: XM_038600012   ⟹   XP_038455940
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.059,641,129 - 9,649,324 (+)NCBI
RefSeq Acc Id: XM_038600013   ⟹   XP_038455941
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.059,642,015 - 9,649,324 (+)NCBI
RefSeq Acc Id: XM_038664552   ⟹   XP_038520480
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.059,598,546 - 9,606,762 (+)NCBI
RefSeq Acc Id: XM_038664553   ⟹   XP_038520481
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.059,599,437 - 9,606,762 (+)NCBI
RefSeq Acc Id: XM_546427   ⟹   XP_546427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.159,658,920 - 9,667,134 (+)NCBI
Dog10K_Boxer_Tasha59,703,800 - 9,712,017 (+)NCBI
Sequence:
RefSeq Acc Id: XP_546427   ⟸   XM_546427
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NPR6 (UniProtKB/TrEMBL),   A0A8P0SG52 (UniProtKB/TrEMBL),   A0A8C0T3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005619675   ⟸   XM_005619618
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016408   ⟸   ENSCAFT00000017725
RefSeq Acc Id: XP_038330608   ⟸   XM_038474680
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038455940   ⟸   XM_038600012
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038455941   ⟸   XM_038600013
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038520480   ⟸   XM_038664552
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KD44 (UniProtKB/TrEMBL),   A0A8I3RWV8 (UniProtKB/TrEMBL),   A0A8C0T3D3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038520481   ⟸   XM_038664553
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T3D3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391738   ⟸   XM_038535810
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KD44 (UniProtKB/TrEMBL),   A0A8C0T3D3 (UniProtKB/TrEMBL),   A0A8I3RWV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038391739   ⟸   XM_038535811
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T3D3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845016811   ⟸   ENSCAFT00845021385
Protein Domains
Ig-like

Promoters
RGD ID:13683109
Promoter ID:EPDNEW_C1177
Type:single initiation site
Name:ESAM_1
Description:endothelial cell adhesion molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.159,658,932 - 9,658,992EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011147 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015902 UniProtKB/TrEMBL
  ENSCAFG00040018910 UniProtKB/TrEMBL
  ENSCAFG00845012033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017725.5 UniProtKB/TrEMBL
  ENSCAFT00030029275.1 UniProtKB/TrEMBL
  ENSCAFT00040034950.1 UniProtKB/TrEMBL
  ENSCAFT00040034988.1 UniProtKB/TrEMBL
  ENSCAFT00845021385 ENTREZGENE
  ENSCAFT00845021385.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro ESAM UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
NCBI Gene ESAM ENTREZGENE
PANTHER ENDOTHELIAL CELL-SELECTIVE ADHESION MOLECULE UniProtKB/TrEMBL
  PTHR44549 UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8C0KD44 ENTREZGENE
  A0A8C0NPR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T3D3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T534_CANLF UniProtKB/TrEMBL
  A0A8I3RWV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SG52 ENTREZGENE
UniProt Secondary A0A8P0SG52 UniProtKB/TrEMBL
VGNC ID VGNC:53356 ENTREZGENE