MCL1 (MCL1 apoptosis regulator, BCL2 family member)

Gene: MCL1 (MCL1 apoptosis regulator, BCL2 family member) Canis lupus familiaris

Analyze

Symbol:

MCL1

Name:

MCL1 apoptosis regulator, BCL2 family member

RGD ID:

12081468

Description:

ENCODES a protein that exhibits BH domain binding (ortholog); protein dimerization activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN DNA damage response (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; interleukin-6 signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH Barrett's esophagus (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytosol (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BCL2 family apoptosis regulator; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; MCL1, BCL2 family apoptosis regulator; myeloid cell leukemia sequence 1 (BCL2-related)

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	59,759,605 - 59,763,111 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	59,759,605 - 59,763,111 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	59,205,905 - 59,209,411 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	60,773,751 - 60,778,808 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	60,773,753 - 60,778,722 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	59,605,427 - 59,608,935 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,689,378 - 59,692,878 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	60,416,999 - 60,420,508 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Barrett's esophagus (ISO)

colon cancer (ISO)

colorectal cancer (ISO)

COVID-19 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

High Myopia (ISO)

immunodeficiency 42 (ISO)

Intestinal Neoplasms (ISO)

leishmaniasis (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

MHC class II deficiency (ISO)

multiple myeloma (ISO)

parathyroid carcinoma (ISO)

primary cutaneous T-cell non-Hodgkin lymphoma (ISO)

sarcoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

stomach cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

cell differentiation (IEA)

DNA damage response (IEA,ISO)

extrinsic apoptotic signaling pathway in absence of ligand (IBA,IEA,ISS)

intrinsic apoptotic signaling pathway in response to DNA damage (IBA,IEA,ISO)

mitochondrial fusion (IBA)

negative regulation of anoikis (IEA)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of autophagy (IEA)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA)

positive regulation of apoptotic process (IEA)

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (IEA)

regulation of apoptotic process (IEA)

release of cytochrome c from mitochondria (IBA)

response to cytokine (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

Bcl-2 family protein complex (IEA,ISO)

cytoplasm (IEA)

cytosol (IEA,ISS)

membrane (IEA,ISS)

mitochondrial outer membrane (IBA,IEA)

mitochondrion (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

BH domain binding (IBA,ISO)

BH3 domain binding (IEA)

channel activity (IBA)

protein binding (ISO)

protein dimerization activity (ISO)

protein heterodimerization activity (IEA,ISS)

protein homodimerization activity (IEA)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

interleukin-6 signaling pathway (ISO)

intrinsic apoptotic pathway (ISO)

References

Additional References at PubMed

PMID:15240948	PMID:15563927	PMID:19185893	PMID:23428776	PMID:30032202

Genomics

Comparative Map Data

MCL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	59,759,605 - 59,763,111 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	59,759,605 - 59,763,111 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	59,205,905 - 59,209,411 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	60,773,751 - 60,778,808 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	60,773,753 - 60,778,722 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	59,605,427 - 59,608,935 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,689,378 - 59,692,878 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	60,416,999 - 60,420,508 (-)	NCBI		UU_Cfam_GSD_1.0

MCL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	150,574,558 - 150,579,610 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	150,560,895 - 150,579,738 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	150,547,034 - 150,552,086 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	148,813,658 - 148,818,760 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	147,360,106 - 147,365,209	NCBI
Celera	1	123,662,793 - 123,667,900 (-)	NCBI		Celera
Cytogenetic Map	1	q21.2	NCBI
HuRef	1	121,925,157 - 121,930,349 (-)	NCBI		HuRef
CHM1_1	1	151,942,802 - 151,947,994 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	149,698,578 - 149,703,635 (-)	NCBI		T2T-CHM13v2.0

Mcl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	95,564,017 - 95,583,553 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	95,566,099 - 95,570,487 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	95,656,944 - 95,663,179 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	95,658,788 - 95,663,176 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	95,462,643 - 95,467,102 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	95,744,192 - 95,748,584 (+)	NCBI		MGSCv36	mm8
MGSCv36	3	95,942,505 - 95,946,924 (+)	NCBI		MGSCv36	mm8
Celera	3	97,090,304 - 97,094,626 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.74	NCBI

Mcl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,884,840 - 185,912,532 (+)	NCBI		GRCr8
mRatBN7.2	2	183,219,137 - 183,235,676 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	183,219,220 - 183,222,303 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,884,075 - 190,887,160 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,679,562 - 188,682,647 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	183,516,603 - 183,519,688 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	197,786,212 - 197,788,992 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	217,273,158 - 217,275,930 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	175,749,995 - 175,752,956 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Mcl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955413	238,043 - 243,317 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	99,257,840 - 99,264,868 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	99,013,464 - 99,018,758 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	125,918,760 - 125,923,952 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	129,566,827 - 129,572,086 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	129,566,827 - 129,572,086 (-)	Ensembl	panpan1.1		panPan2

Mcl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,772,943 - 21,777,059 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	804,903 - 806,796 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	803,452 - 806,966 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	98,534,812 - 98,567,006 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	98,562,092 - 98,567,014 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	107,809,204 - 107,814,036 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666038	12,707,472 - 12,712,711 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mcl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	18,289,509 - 18,319,033 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	18,287,587 - 18,292,384 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MCL1
58 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	22	6	6	6	6	6	12	8	10	6
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038690428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB093582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000019132 ⟹ ENSCAFP00000017738

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	17	59,759,605 - 59,763,111 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000076312 ⟹ ENSCAFP00000046220

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	17	59,759,605 - 59,763,030 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845032721 ⟹ ENSCAFP00845025596

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	17	60,773,753 - 60,778,722 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845032754 ⟹ ENSCAFP00845025628

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	17	60,773,753 - 60,778,541 (-)	Ensembl

RefSeq Acc Id:

NM_001003016 ⟹ NP_001003016

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	17	59,759,605 - 59,763,111 (-)	NCBI
Dog10K_Boxer_Tasha	17	59,205,905 - 59,209,411 (-)	NCBI
ROS_Cfam_1.0	17	60,775,117 - 60,778,622 (-)	NCBI
UMICH_Zoey_3.1	17	59,605,427 - 59,608,935 (-)	NCBI
UNSW_CanFamBas_1.0	17	59,689,378 - 59,692,878 (-)	NCBI
UU_Cfam_GSD_1.0	17	60,416,999 - 60,420,508 (-)	NCBI

Sequence:

show sequence

TCAACTGAGGAGTCGGGGCCATCCCCATTTTTCTCACTCAGGAGGCGGCGGCGGCGGCGGCGGC
GGCGGCAGGAGCTTGCGATGTTCGGCCTCAAGAGAAACGCAGTAATCGGACTCAACCTCTACTG
TGGGGGGGCCGGGCTGGGGGCCGGCAGCGGCGGCGCCTCCTCTTCGGGAGGGCGGCTTTTGGCT
TCGGGGAAGGAGGCCACGACCAGACGGGAGGGAGGGGGAGGGGAAGCCGGTGCGGTGATTGGCG
GAAGCGCCGGCGCAAGTCCCCCGACCACTCTGGCGCCGGACGCCCGGAGGGTCGCGCGGCCCTC
ACCCATTGGCGCTGAGGGCCCCAACGTCAGCGCGACCCCCCCGAGGCTGCTGCTGCTCGCGCCC
CCCTGCCGCGCGTCGCCGCCTGAAGAGATGGAAGGCCCGGCCGCCGACGCCATCATGTCGCCCG
AAGAGGAGCTAGACGGGTACGAGCCGGAACCTTTGGGGAAGCGGCCGGCGGTCCTGCCTCTGCT
GGAGTTGGTGGGGGAGGCCAGCAGTGGCCCCGGCATGGACGGCTCGCTACCCTCGACGCCACCC
CCGGCGGAGGAGGAGGAAGATGAGTTGTACCGGCAGTCCCTGGAGATTATCTCTCGGTACCTTC
GGGAACAGGCCACAGGCGCCAAGGACGCGAAACCACTGGGCGGGTCTCGGGCGGCCAGCCGGAA
GGCGTTAGAGACCCTCCGGCGAGTCGGGGACGGGGTACAGCGCAACCACGAGACAGCCTTCCAA
GGCATGCTTCGGAAACTGGACATCAAAAACGAAGACGATGTCAAATCGTTGTCTCGAGTGATTG
TCCATGTTTTCAGTGACGGAGTAACAAACTGGGGCAGGATTGTGACTCTTATTTCCTTTGGTGC
CTTTGTGGCCAAACACTTGAAGAGTATAAACCAAGAAAGCTGCATCGAACCATTAGCAGAAAGC
ATCACAGATGTTCTCGTAAGGACGAAACGAGACTGGCTAGTCAAACAAAGAGGCTGGGATGGGT
TTGTGGAGTTCTTCCATGTAGAGGACCTAGAAGGTGGCATCAGAAATGTGCTGCTGGCTTTTGC
AGGTGTTGCTGGAGTAGGAGCTGGTTTGGCATATCTAATAAGATAGCCTTTTAAGTGCAATAAT
TAACTTTTAAACAACCCCAGGCACCAAAACCACATATGACTGCTGTGAAATCAAATGTATTTAT
GAAGTTGGACTTTGAGCTGTCCAGGCTGTAACCTCGGAGAGTTCTACTCTAGCAACGTAGAAAA
GCAAGTGGCAAGAGGATTATGGCTAACAGGAATAAATACATGGGAGAAGTAGTCCCCCTTGAAG
AGTCACTGTCTAAAAGAAGCAGAGCTCAGTTTCAGCAACAGGCAAACTTGGGGAGGCCATGGAG
GAGGACTTTTAGATTTAGTAAAGTTGGTAGGGTTGAAGAGACTTAATTTTCTTGTCTAGAACAG
GAGAGTGGCCAGTAGCCAGGCTAGTCATAGAGTCCATTAAATATGTCCACTGAATTCATTAACT
TCCCATATAGTGTTAAAAGAGAAGCACTAACAATGGCATTGATCTGTATGAAATGGATTTAAGC
TACAGGTGATAGAACTATGACTAGAAGCCGCAGTACTGTACAACAGTGTGAAGGAAAGCTTTTT
CTCTGTAATTAGCTTTCCCAAGTATACTTCTTGAAAGTCCAAGTGCTCAGGACGTTTTTACCTG
TTCTACTTTGGCTTGGTTTGAGTGGTTTAGTTTATTAGCCTAGTAATGGCCAACAATACTTGAC
TTAGGGTCAATAATTACAATTGCAAATGTGGGAATAGCCTCAATTTTTAAGGCAAAAACAAATT
GTAAATGTATTTGTCTGTAAAAATTGTGTATATTTTTACAGAAAGTCTATTTCTTTGAAATGTA
AAGGGATGAAGAGTCTCAAAATATATTAGTTTTTTTTTCATGCCCGTTTGAAATTTACAACTTC
TGTAGTTAGGAATCTATTTCTTACAGCTTTTCTAAATTTTGTCCTGGTCAGTTCTAGATTGTAT
ACAGAACCAATTGATGTAATTGTATGCAACTTGGTTGTAGTGGAACAATTCCAATTCATAACTA
TGCAGACTTTTTAATTTTCCTATCTGATTGGTAAGTATTCTTTAGTGGTTTTGGGTGTTTTGTT
TTGTTTTAAACCTGGGATTGAGAAGTTGATGAATGGAAATTCATCCTTTAACTTCATTACATGT
GGGTTTACAATAATTGAGTCAAGGTGAAGTTTGAAGTTTGGGGGCAGGGGGTGTGTGTGGGTTG
ATAACTTAAAAAAATAATGGGCTCTGATTGGGCAGCTACTCATTTGAGTTCCTTCCATTTGACC
TAATTTAACTGGTGAAATTTAAATTGAGTTTATGAGCTCATCTTCAAAACTTTTGCTAGAAGAT
TTTCAGCTGTTCCAAATGGGACTTACTAACAGTATGTATATAAAAAGATCACATCAGTGGATGA
GAGACATTTGATCCCTTGTTTGCTTAATAAATTGTAAAATGATGGCTTGGAAAAGCAGGCTTAT
AGTCTAACCATGGTGCTATTATTAGGCTTGCTTGTTAAACACAGGTCTAAGCCTAGTATATCAA
TAAAACAAATACTTATTTCATTTG

hide sequence

RefSeq Acc Id:

XM_038690428 ⟹ XP_038546356

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	17	60,773,751 - 60,778,808 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001003016	(Get FASTA)	NCBI Sequence Viewer
	XP_038546356	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC21258	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000017738.2
	ENSCAFP00000046220.1
	ENSCAFP00030009903.1
	ENSCAFP00030009921.1
	ENSCAFP00040017296.1
	ENSCAFP00040017366.1
	ENSCAFP00845025596
	ENSCAFP00845025596.1
	ENSCAFP00845025628.1
GenBank Protein	Q8HYS5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001003016 ⟸ NM_001003016

- UniProtKB:

Q8HYS5 (UniProtKB/Swiss-Prot), A0A8C0MD43 (UniProtKB/TrEMBL), A0A8C0L4C8 (UniProtKB/TrEMBL), A0A8I3P430 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFGLKRNAVIGLNLYCGGAGLGAGSGGASSSGGRLLASGKEATTRREGGGGEAGAVIGGSAGAS
PPTTLAPDARRVARPSPIGAEGPNVSATPPRLLLLAPPCRASPPEEMEGPAADAIMSPEEELDG
YEPEPLGKRPAVLPLLELVGEASSGPGMDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATG
AKDAKPLGGSRAASRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVIVHVFSD
GVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
VEDLEGGIRNVLLAFAGVAGVGAGLAYLIR

hide sequence

RefSeq Acc Id:

ENSCAFP00000017738 ⟸ ENSCAFT00000019132

RefSeq Acc Id:

ENSCAFP00000046220 ⟸ ENSCAFT00000076312

RefSeq Acc Id:	XP_038546356 ⟸ XM_038690428
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0MCZ5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845025628 ⟸ ENSCAFT00845032754

RefSeq Acc Id:

ENSCAFP00845025596 ⟸ ENSCAFT00845032721

Protein Domains

Bcl-2 Bcl-2 homology region 1-3

Promoters

RGD ID:

13686388

Promoter ID:

EPDNEW_C4458

Type:

multiple initiation site

Name:

MCL1_1

Description:

MCL1, BCL2 family apoptosis regulator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	17	59,763,131 - 59,763,191	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000012050	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030006114	UniProtKB/TrEMBL
	ENSCAFG00040010751	UniProtKB/TrEMBL
	ENSCAFG00845018496	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000019132.4	UniProtKB/TrEMBL
	ENSCAFT00000076312.2	UniProtKB/TrEMBL
	ENSCAFT00030011328.1	UniProtKB/TrEMBL
	ENSCAFT00030011346.1	UniProtKB/TrEMBL
	ENSCAFT00040019936.1	UniProtKB/TrEMBL
	ENSCAFT00040020013.1	UniProtKB/TrEMBL
	ENSCAFT00845032721	ENTREZGENE
	ENSCAFT00845032721.1	UniProtKB/TrEMBL
	ENSCAFT00845032754.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.437.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Apop_reg_Mc1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl-2-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl-2_BH1-3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl-2_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl2_BH1_motif_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl2_BH2_motif_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Bcl2_BH3_motif_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:403537	UniProtKB/TrEMBL
NCBI Gene	MCL1	ENTREZGENE
PANTHER	PTHR11256	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11256:SF46	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Bcl-2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	APOPREGMCL1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BCL2FAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	BCL2_FAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BH1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BCL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56854	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0L4C8	ENTREZGENE
	A0A8C0MCZ5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0MD43	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0S8A7_CANLF	UniProtKB/TrEMBL
	A0A8I3P430	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P6T4_CANLF	UniProtKB/TrEMBL
	MCL1_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID	VGNC:43079	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-30	MCL1	MCL1 apoptosis regulator, BCL2 family member		MCL1, BCL2 family apoptosis regulator	Symbol and/or name change	5135510	APPROVED
2017-03-08	MCL1	MCL1, BCL2 family apoptosis regulator		BCL2 family apoptosis regulator	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)