LRRC14B (leucine rich repeat containing 14B) - Rat Genome Database

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Gene: LRRC14B (leucine rich repeat containing 14B) Canis lupus familiaris
Analyze
Symbol: LRRC14B
Name: leucine rich repeat containing 14B
RGD ID: 12078348
Description: ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat-containing protein 14B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,978,345 - 11,990,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,982,394 - 11,985,329 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,491,590 - 16,504,184 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,883,384 - 11,892,615 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,880,018 - 11,889,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,932,470 - 11,945,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,918,990 - 11,931,580 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,121,098 - 12,133,708 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LRRC14B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,978,345 - 11,990,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,982,394 - 11,985,329 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,491,590 - 16,504,184 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,883,384 - 11,892,615 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,880,018 - 11,889,469 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,932,470 - 11,945,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,918,990 - 11,931,580 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,121,098 - 12,133,708 (-)NCBIUU_Cfam_GSD_1.0
LRRC14B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385191,495 - 196,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5191,495 - 196,334 (+)EnsemblGRCh38hg38GRCh38
GRCh375191,610 - 196,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365244,626 - 248,468 (+)NCBINCBI36Build 36hg18NCBI36
Celera5291,236 - 295,074 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5181,453 - 185,345 (+)NCBIHuRef
CHM1_15190,313 - 194,155 (+)NCBICHM1_1
T2T-CHM13v2.05182,851 - 187,790 (+)NCBIT2T-CHM13v2.0
Lrrc14b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,507,701 - 74,512,119 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,507,697 - 74,512,124 (-)EnsemblGRCm39 Ensembl
GRCm381374,359,582 - 74,364,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,359,578 - 74,364,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv371374,497,030 - 74,501,448 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,825,584 - 74,830,002 (-)NCBIMGSCv36mm8
Celera1376,689,799 - 76,694,218 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.22NCBI
Lrrc14b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,748,103 - 30,754,236 (+)NCBIGRCr8
mRatBN7.2128,921,475 - 28,925,646 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,921,416 - 28,925,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,722,629 - 28,726,801 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,722,483 - 34,726,655 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,923,251 - 28,927,423 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,531,143 - 31,535,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,531,143 - 31,535,314 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0132,957,291 - 32,961,462 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,724,871 - 29,729,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera127,573,322 - 27,577,493 (+)NCBICelera
Cytogenetic Map1p11NCBI
Lrrc14b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555049,014 - 13,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555049,559 - 13,238 (+)NCBIChiLan1.0ChiLan1.0
LRRC14B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24411,315 - 416,117 (+)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl5332,054 - 336,881 (+)Ensemblpanpan1.1panPan2
Lrrc14b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213245,024,531 - 245,028,411 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368151,185,409 - 1,189,669 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368151,185,648 - 1,189,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC14B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,877,256 - 79,882,960 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,877,618 - 79,883,027 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LRRC14B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14132,428 - 148,965 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4133,339 - 143,458 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236669721,249 - 6,652 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc14b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475129,324 - 33,001 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475129,373 - 32,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LRRC14B
170 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 1 6
Below cutoff 5 22 6 5 6 6 12 8 10 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022414190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038445579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038583395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038647808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_545199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002622571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005306762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005349736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005383726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005417380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000045302   ⟹   ENSCAFP00000036780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3411,982,394 - 11,985,329 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845027207   ⟹   ENSCAFP00845021402
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3411,880,018 - 11,889,469 (-)Ensembl
RefSeq Acc Id: XM_022414190   ⟹   XP_022269898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13411,978,345 - 11,990,951 (-)NCBI
Dog10K_Boxer_Tasha3416,491,590 - 16,504,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038445578   ⟹   XP_038301506
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03411,883,384 - 11,887,399 (-)NCBI
RefSeq Acc Id: XM_038445579   ⟹   XP_038301507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03411,883,384 - 11,892,615 (-)NCBI
RefSeq Acc Id: XM_038519753   ⟹   XP_038375681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13411,932,470 - 11,939,855 (-)NCBI
RefSeq Acc Id: XM_038519754   ⟹   XP_038375682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13411,932,470 - 11,945,070 (-)NCBI
RefSeq Acc Id: XM_038583394   ⟹   XP_038439322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03412,121,098 - 12,128,493 (-)NCBI
RefSeq Acc Id: XM_038583395   ⟹   XP_038439323
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03412,121,098 - 12,133,708 (-)NCBI
RefSeq Acc Id: XM_038647807   ⟹   XP_038503735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03411,918,990 - 11,926,376 (-)NCBI
RefSeq Acc Id: XM_038647808   ⟹   XP_038503736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03411,918,990 - 11,931,580 (-)NCBI
RefSeq Acc Id: XM_545199   ⟹   XP_545199
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13411,978,345 - 11,987,660 (-)NCBI
Dog10K_Boxer_Tasha3416,491,590 - 16,498,980 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002622571
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13411,978,345 - 11,987,660 (-)NCBI
Dog10K_Boxer_Tasha3416,491,590 - 16,498,980 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005306762
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03411,883,384 - 11,887,399 (-)NCBI
RefSeq Acc Id: XR_005349736
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13411,932,470 - 11,939,855 (-)NCBI
RefSeq Acc Id: XR_005383726
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03412,121,098 - 12,128,493 (-)NCBI
RefSeq Acc Id: XR_005417380
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03411,918,990 - 11,926,376 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_545199   ⟸   XM_545199
- Peptide Label: isoform X1
- UniProtKB: A0A8P0PIP8 (UniProtKB/TrEMBL),   A0A8C0P020 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022269898   ⟸   XM_022414190
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P020 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000036780   ⟸   ENSCAFT00000045302
RefSeq Acc Id: XP_038375682   ⟸   XM_038519754
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038375681   ⟸   XM_038519753
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038503736   ⟸   XM_038647808
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038503735   ⟸   XM_038647807
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038301507   ⟸   XM_038445579
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T7Y2 (UniProtKB/TrEMBL),   A0A8C0P020 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038301506   ⟸   XM_038445578
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LFD9 (UniProtKB/TrEMBL),   A0A8I3NTA6 (UniProtKB/TrEMBL),   A0A8C0P020 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439323   ⟸   XM_038583395
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P020 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439322   ⟸   XM_038583394
- Peptide Label: isoform X1
- UniProtKB: A0A8C0P020 (UniProtKB/TrEMBL),   A0A8P0PIP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845021402   ⟸   ENSCAFT00845027207


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029782 Ensembl
  ENSCAFG00000055732 UniProtKB/TrEMBL
  ENSCAFG00030019498 UniProtKB/TrEMBL
  ENSCAFG00040019164 UniProtKB/TrEMBL
  ENSCAFG00845015253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000108082.1 UniProtKB/TrEMBL
  ENSCAFT00030035802.1 UniProtKB/TrEMBL
  ENSCAFT00040035441.1 UniProtKB/TrEMBL
  ENSCAFT00845027207 ENTREZGENE
  ENSCAFT00845027207.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro LRR_dom_sf UniProtKB/TrEMBL
NCBI Gene LRRC14B ENTREZGENE
PANTHER LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14B UniProtKB/TrEMBL
  SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt A0A8C0LFD9 ENTREZGENE
  A0A8C0P020 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T7Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NTA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PIP8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42785 ENTREZGENE