HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1) - Rat Genome Database

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Gene: HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1) Canis lupus familiaris
Analyze
Symbol: HSD17B1
Name: hydroxysteroid 17-beta dehydrogenase 1
RGD ID: 12075378
Description: ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase activity (ortholog); NADP binding (ortholog); steroid binding (ortholog); INVOLVED IN bone development (ortholog); cellular response to metal ion (ortholog); estrogen biosynthetic process (ortholog); PARTICIPATES IN estradiol biosynthetic pathway; ASSOCIATED WITH endometriosis (ortholog); invasive ductal carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 17-beta-dehydrogenase 1; 17-beta-hydroxysteroid dehydrogenase type 1; estradiol 17-beta-dehydrogenase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,402,124 - 20,407,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,405,019 - 20,406,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,866,871 - 19,868,985 (-)NCBI
ROS_Cfam_1.0921,123,971 - 21,126,087 (-)NCBI
UMICH_Zoey_3.1919,909,803 - 19,911,916 (-)NCBI
UNSW_CanFamBas_1.0920,175,037 - 20,177,147 (-)NCBI
UU_Cfam_GSD_1.0920,279,091 - 20,281,208 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:23691576  


Genomics

Comparative Map Data
HSD17B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,402,124 - 20,407,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,405,019 - 20,406,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,866,871 - 19,868,985 (-)NCBI
ROS_Cfam_1.0921,123,971 - 21,126,087 (-)NCBI
UMICH_Zoey_3.1919,909,803 - 19,911,916 (-)NCBI
UNSW_CanFamBas_1.0920,175,037 - 20,177,147 (-)NCBI
UU_Cfam_GSD_1.0920,279,091 - 20,281,208 (-)NCBI
HSD17B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,552,922 - 42,555,214 (+)EnsemblGRCh38hg38GRCh38
GRCh381742,552,923 - 42,555,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,704,941 - 40,707,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,957,510 - 37,960,757 (+)NCBINCBI36hg18NCBI36
Build 341737,957,509 - 37,960,757NCBI
Celera1737,359,920 - 37,363,168 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,468,996 - 36,472,244 (+)NCBIHuRef
CHM1_11740,939,828 - 40,943,076 (+)NCBICHM1_1
Hsd17b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,968,792 - 100,972,014 (+)NCBIGRCm39mm39
GRCm39 Ensembl11100,969,237 - 100,971,353 (+)Ensembl
GRCm3811101,077,968 - 101,081,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,078,411 - 101,080,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,939,725 - 100,941,819 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611100,894,501 - 100,896,595 (+)NCBImm8
Celera11112,374,513 - 112,376,607 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.17NCBI
Hsd17b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,009,728 - 86,011,928 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01088,987,558 - 88,989,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01088,786,054 - 88,788,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,094,249 - 90,096,451 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11090,108,618 - 90,110,820 (+)NCBI
Celera1084,727,443 - 84,729,643 (+)NCBICelera
Cytogenetic Map10q31NCBI
Hsd17b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,449,683 - 16,451,945 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,449,333 - 16,452,036 (+)NCBIChiLan1.0ChiLan1.0
HSD17B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11714,986,538 - 14,989,741 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,986,814 - 14,988,820 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01714,760,856 - 14,763,584 (-)NCBIMhudiblu_PPA_v0panPan3
Hsd17b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,760,718 - 19,762,826 (-)NCBI
SpeTri2.0NW_00493649017,312,390 - 17,314,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,269,056 - 20,279,569 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,269,468 - 20,271,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,482,373 - 20,484,253 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,730,303 - 63,733,974 (-)NCBI
ChlSab1.1 Ensembl1663,728,777 - 63,732,411 (-)Ensembl
Vero_WHO_p1.0NW_02366607734,525,962 - 34,529,030 (-)NCBI
Hsd17b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,551,311 - 1,553,432 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 4 15 5 1 12 8
Below cutoff 1 5 7 6 1 6 5 6 8 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023737   ⟹   ENSCAFP00000022032
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl920,405,019 - 20,406,792 (-)Ensembl
RefSeq Acc Id: XM_005624453   ⟹   XP_005624510
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1920,405,423 - 20,407,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038484499   ⟹   XP_038340427
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1919,909,803 - 19,911,916 (-)NCBI
RefSeq Acc Id: XM_038546021   ⟹   XP_038401949
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0920,279,091 - 20,281,208 (-)NCBI
RefSeq Acc Id: XM_038610047   ⟹   XP_038465975
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0920,175,037 - 20,177,147 (-)NCBI
RefSeq Acc Id: XM_038675110   ⟹   XP_038531038
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0921,123,971 - 21,126,087 (-)NCBI
RefSeq Acc Id: XM_844306   ⟹   XP_849399
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1920,402,124 - 20,407,143 (-)NCBI
Dog10K_Boxer_Tasha919,866,871 - 19,868,985 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_849399   ⟸   XM_844306
- UniProtKB: E2RI88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005624510   ⟸   XM_005624453
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000022032   ⟸   ENSCAFT00000023737
RefSeq Acc Id: XP_038340427   ⟸   XM_038484499
RefSeq Acc Id: XP_038465975   ⟸   XM_038610047
RefSeq Acc Id: XP_038531038   ⟸   XM_038675110
RefSeq Acc Id: XP_038401949   ⟸   XM_038546021


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014961 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000022032 ENTREZGENE
NCBI Gene HSD17B1 ENTREZGENE
UniProt E2RI88 ENTREZGENE
VGNC ID VGNC:41800 ENTREZGENE