PRKD2 (protein kinase D2) - Rat Genome Database

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Gene: PRKD2 (protein kinase D2) Canis lupus familiaris
Analyze
Symbol: PRKD2
Name: protein kinase D2
RGD ID: 12073435
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN cellular response to vascular endothelial growth factor stimulus (inferred); intracellular signal transduction (inferred); positive regulation of angiogenesis (inferred); ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); genetic disease (ortholog); long QT syndrome 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase D2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,206,400 - 109,241,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,207,067 - 109,330,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,686,213 - 108,721,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,732,886 - 109,767,802 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,732,806 - 109,767,767 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,410,008 - 109,444,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,044,199 - 109,079,115 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,912,894 - 109,947,820 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,206,400 - 109,241,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,207,067 - 109,330,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,686,213 - 108,721,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,732,886 - 109,767,802 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,732,806 - 109,767,767 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,410,008 - 109,444,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,044,199 - 109,079,115 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,912,894 - 109,947,820 (+)NCBIUU_Cfam_GSD_1.0
PRKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,674,316 - 46,717,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,674,275 - 46,717,127 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,177,573 - 47,220,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,869,413 - 51,912,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,869,412 - 51,911,506NCBI
Celera1943,981,103 - 44,023,914 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,602,696 - 43,645,312 (-)NCBIHuRef
CHM1_11947,179,449 - 47,222,284 (-)NCBICHM1_1
T2T-CHM13v2.01949,499,855 - 49,545,002 (-)NCBIT2T-CHM13v2.0
Prkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,576,827 - 16,604,386 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,576,827 - 16,604,389 (+)EnsemblGRCm39 Ensembl
GRCm38716,842,902 - 16,870,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,842,902 - 16,870,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,428,414 - 17,455,810 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36716,001,587 - 16,028,983 (+)NCBIMGSCv36mm8
Celera714,041,053 - 14,076,870 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Prkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,640,095 - 86,670,476 (+)NCBIGRCr8
mRatBN7.2177,513,625 - 77,542,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,513,986 - 77,542,376 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,894,204 - 82,922,473 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,458,248 - 91,486,518 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,649,293 - 84,677,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,767,911 - 78,796,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,767,911 - 78,796,231 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0180,015,106 - 80,043,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,168,290 - 77,197,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,246,400 - 77,275,388 (+)NCBI
Celera171,999,137 - 72,027,468 (+)NCBICelera
Cytogenetic Map1q21NCBI
Prkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574723,933 - 750,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574723,933 - 750,794 (-)NCBIChiLan1.0ChiLan1.0
PRKD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,824,032 - 52,868,739 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,694,894 - 54,739,621 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,666,591 - 43,710,858 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,195,096 - 52,238,758 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,195,303 - 52,237,731 (-)Ensemblpanpan1.1panPan2
Prkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,906,807 - 18,933,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664522,910 - 551,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936664524,532 - 551,451 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,559,393 - 52,599,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,559,066 - 52,599,174 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,880,007 - 47,919,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,028,214 - 40,071,523 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,027,552 - 40,071,455 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,740,729 - 19,783,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,886,327 - 6,915,179 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,885,627 - 6,915,316 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKD2
236 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 5 2 6 5
Low 4 5 16 6 1 6 4 6 6 8 5 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005616411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005616412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014119463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000006841   ⟹   ENSCAFP00000006334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,207,067 - 109,241,450 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064705   ⟹   ENSCAFP00000047362
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,207,071 - 109,330,007 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089891   ⟹   ENSCAFP00000047470
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,207,071 - 109,266,324 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090158   ⟹   ENSCAFP00000057287
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,207,071 - 109,241,247 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845006019   ⟹   ENSCAFP00845004782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1109,732,806 - 109,767,767 (+)Ensembl
RefSeq Acc Id: XM_005616411   ⟹   XP_005616468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11109,206,401 - 109,241,529 (+)NCBI
Dog10K_Boxer_Tasha1108,686,213 - 108,721,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005616412   ⟹   XP_005616469
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11109,207,172 - 109,241,529 (+)NCBI
Dog10K_Boxer_Tasha1108,686,973 - 108,721,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038467769   ⟹   XP_038323697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11109,410,008 - 109,444,923 (+)NCBI
RefSeq Acc Id: XM_038467770   ⟹   XP_038323698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11109,410,768 - 109,444,923 (+)NCBI
RefSeq Acc Id: XM_038528489   ⟹   XP_038384417
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01109,912,894 - 109,947,820 (+)NCBI
RefSeq Acc Id: XM_038528490   ⟹   XP_038384418
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01109,913,654 - 109,947,820 (+)NCBI
RefSeq Acc Id: XM_038592770   ⟹   XP_038448698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01109,044,199 - 109,079,115 (+)NCBI
RefSeq Acc Id: XM_038592771   ⟹   XP_038448699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01109,044,959 - 109,079,115 (+)NCBI
RefSeq Acc Id: XM_038656570   ⟹   XP_038512498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01109,732,886 - 109,767,802 (+)NCBI
RefSeq Acc Id: XM_038656571   ⟹   XP_038512499
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01109,733,646 - 109,767,802 (+)NCBI
RefSeq Acc Id: XP_005616468   ⟸   XM_005616411
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JLY4 (UniProtKB/TrEMBL),   A0A8C0RE79 (UniProtKB/TrEMBL),   A0A8I3MQ74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005616469   ⟸   XM_005616412
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000047362   ⟸   ENSCAFT00000064705
RefSeq Acc Id: ENSCAFP00000006334   ⟸   ENSCAFT00000006841
RefSeq Acc Id: ENSCAFP00000057287   ⟸   ENSCAFT00000090158
RefSeq Acc Id: ENSCAFP00000047470   ⟸   ENSCAFT00000089891
RefSeq Acc Id: XP_038323697   ⟸   XM_038467769
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038323698   ⟸   XM_038467770
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038448698   ⟸   XM_038592770
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038448699   ⟸   XM_038592771
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038512498   ⟸   XM_038656570
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JLY4 (UniProtKB/TrEMBL),   A0A8C0RE79 (UniProtKB/TrEMBL),   A0A8I3MQ74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512499   ⟸   XM_038656571
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038384417   ⟸   XM_038528489
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JLY4 (UniProtKB/TrEMBL),   A0A8C0RE79 (UniProtKB/TrEMBL),   A0A8I3MQ74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384418   ⟸   XM_038528490
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845004782   ⟸   ENSCAFT00845006019
Protein Domains
PH   Phorbol-ester/DAG-type   Protein kinase

Promoters
RGD ID:13682225
Promoter ID:EPDNEW_C293
Type:multiple initiation site
Name:PRKD2_1
Description:protein kinase D2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11109,206,330 - 109,206,390EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004256 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006593 UniProtKB/TrEMBL
  ENSCAFG00040002904 UniProtKB/TrEMBL
  ENSCAFG00845003382 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006841.5 UniProtKB/TrEMBL
  ENSCAFT00030012356.1 UniProtKB/TrEMBL
  ENSCAFT00040005589.1 UniProtKB/TrEMBL
  ENSCAFT00845006019 ENTREZGENE
  ENSCAFT00845006019.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Protein_Kinase_C_mu-related UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PRKD2 ENTREZGENE
PANTHER PTHR22968 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE D2 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF PKC_mu_nu_D2 UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8C0JLY4 ENTREZGENE
  A0A8C0RE79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQ74 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44987 ENTREZGENE