GPR18 (G protein-coupled receptor 18) - Rat Genome Database

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Gene: GPR18 (G protein-coupled receptor 18) Canis lupus familiaris
Analyze
Symbol: GPR18
Name: G protein-coupled receptor 18
RGD ID: 12072808
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN CD8-positive, alpha-beta intraepithelial T cell differentiation (ortholog); CD8-positive, gamma-delta intraepithelial T cell differentiation (ortholog); negative regulation of leukocyte chemotaxis (ortholog); ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); genetic disease (ortholog); holoprosencephaly (ortholog); FOUND IN cytoplasmic vesicle (inferred); cytoplasmic vesicle membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: N-arachidonyl glycine receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12249,288,226 - 49,294,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2249,288,343 - 49,289,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2249,069,390 - 49,076,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02249,729,137 - 49,736,486 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2249,729,269 - 49,730,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12249,380,774 - 49,387,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02249,414,634 - 49,421,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02249,451,114 - 49,458,263 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:9205118   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GPR18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12249,288,226 - 49,294,567 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2249,288,343 - 49,289,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2249,069,390 - 49,076,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02249,729,137 - 49,736,486 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2249,729,269 - 49,730,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12249,380,774 - 49,387,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02249,414,634 - 49,421,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02249,451,114 - 49,458,263 (-)NCBIUU_Cfam_GSD_1.0
GPR18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381399,254,739 - 99,258,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1399,254,732 - 99,261,744 (-)EnsemblGRCh38hg38GRCh38
GRCh371399,906,993 - 99,910,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361398,704,968 - 98,708,683 (-)NCBINCBI36Build 36hg18NCBI36
Build 341398,704,972 - 98,708,629NCBI
Celera1380,750,537 - 80,754,253 (-)NCBICelera
Cytogenetic Map13q32.3NCBI
HuRef1380,501,358 - 80,505,073 (-)NCBIHuRef
CHM1_11399,877,156 - 99,880,871 (-)NCBICHM1_1
T2T-CHM13v2.01398,464,982 - 98,489,443 (-)NCBIT2T-CHM13v2.0
Gpr18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,148,846 - 122,153,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14122,148,665 - 122,153,193 (-)EnsemblGRCm39 Ensembl
GRCm3814121,911,434 - 121,915,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14121,911,253 - 121,915,781 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714122,310,656 - 122,314,996 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614121,046,614 - 121,050,954 (-)NCBIMGSCv36mm8
Celera14120,472,856 - 120,477,195 (-)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1465.86NCBI
Gpr18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815105,404,062 - 105,407,812 (-)NCBIGRCr8
mRatBN7.21598,997,427 - 99,001,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1598,997,259 - 99,001,470 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15102,931,135 - 102,934,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015104,023,208 - 104,026,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015100,951,028 - 100,954,757 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015108,323,157 - 108,326,907 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,323,179 - 108,326,907 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015111,710,713 - 111,714,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415107,014,823 - 107,018,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1597,769,869 - 97,773,606 (-)NCBICelera
Cytogenetic Map15q25NCBI
Gpr18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540411,293,897 - 11,321,072 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540411,293,897 - 11,321,072 (+)NCBIChiLan1.0ChiLan1.0
GPR18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214100,778,706 - 100,816,860 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11399,445,859 - 99,454,370 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01380,423,534 - 80,427,604 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11399,562,425 - 99,566,292 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1399,562,589 - 99,563,584 (-)Ensemblpanpan1.1panPan2
Gpr18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945184,709,977 - 184,714,884 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647211,240,880 - 11,241,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647211,240,287 - 11,242,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1168,187,327 - 68,191,269 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11168,187,402 - 68,191,622 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,421,543 - 75,425,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1377,911,752 - 77,919,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl377,911,915 - 77,912,910 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604634,407,270 - 34,412,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479311,781,250 - 11,785,952 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPR18
87 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 7 4 6 4 2 8 7 3
Below cutoff 5 15 2 2 4 4 12 3 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038431360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038431361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038456611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038506747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038506748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038569943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038569944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038634103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038634104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_542650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000009342   ⟹   ENSCAFP00000035502
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2249,288,343 - 49,289,338 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845038728   ⟹   ENSCAFP00845030324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2249,729,269 - 49,730,264 (-)Ensembl
RefSeq Acc Id: XM_038431360   ⟹   XP_038287288
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02249,729,137 - 49,736,486 (-)NCBI
RefSeq Acc Id: XM_038431361   ⟹   XP_038287289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02249,729,137 - 49,736,486 (-)NCBI
RefSeq Acc Id: XM_038456611   ⟹   XP_038312539
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2249,069,390 - 49,076,594 (-)NCBI
RefSeq Acc Id: XM_038506747   ⟹   XP_038362675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12249,380,774 - 49,387,977 (-)NCBI
RefSeq Acc Id: XM_038506748   ⟹   XP_038362676
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12249,380,774 - 49,387,977 (-)NCBI
RefSeq Acc Id: XM_038569943   ⟹   XP_038425871
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02249,451,114 - 49,458,263 (-)NCBI
RefSeq Acc Id: XM_038569944   ⟹   XP_038425872
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02249,451,114 - 49,458,263 (-)NCBI
RefSeq Acc Id: XM_038634103   ⟹   XP_038490031
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02249,414,634 - 49,421,920 (-)NCBI
RefSeq Acc Id: XM_038634104   ⟹   XP_038490032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02249,414,634 - 49,421,920 (-)NCBI
RefSeq Acc Id: XM_542650   ⟹   XP_542650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12249,288,226 - 49,294,567 (-)NCBI
Dog10K_Boxer_Tasha2249,069,390 - 49,076,594 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_542650   ⟸   XM_542650
- UniProtKB: A0A8C0LDL0 (UniProtKB/TrEMBL),   A0A8C0MFA6 (UniProtKB/TrEMBL),   A0A8I3PH14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000035502   ⟸   ENSCAFT00000009342
RefSeq Acc Id: XP_038362676   ⟸   XM_038506748
RefSeq Acc Id: XP_038362675   ⟸   XM_038506747
RefSeq Acc Id: XP_038490032   ⟸   XM_038634104
RefSeq Acc Id: XP_038490031   ⟸   XM_038634103
RefSeq Acc Id: XP_038287289   ⟸   XM_038431361
- UniProtKB: A0A8C0LDL0 (UniProtKB/TrEMBL),   A0A8C0MFA6 (UniProtKB/TrEMBL),   A0A8I3PH14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038287288   ⟸   XM_038431360
- UniProtKB: A0A8C0LDL0 (UniProtKB/TrEMBL),   A0A8C0MFA6 (UniProtKB/TrEMBL),   A0A8I3PH14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038312539   ⟸   XM_038456611
- UniProtKB: A0A8C0LDL0 (UniProtKB/TrEMBL),   A0A8C0MFA6 (UniProtKB/TrEMBL),   A0A8I3PH14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038425872   ⟸   XM_038569944
- UniProtKB: A0A8C0LDL0 (UniProtKB/TrEMBL),   A0A8C0MFA6 (UniProtKB/TrEMBL),   A0A8I3PH14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038425871   ⟸   XM_038569943
- UniProtKB: A0A8C0LDL0 (UniProtKB/TrEMBL),   A0A8C0MFA6 (UniProtKB/TrEMBL),   A0A8I3PH14 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845030324   ⟸   ENSCAFT00845038728
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005800 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006748 UniProtKB/TrEMBL
  ENSCAFG00040023628 UniProtKB/TrEMBL
  ENSCAFG00845021961 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000009342.4 UniProtKB/TrEMBL
  ENSCAFT00030012408.1 UniProtKB/TrEMBL
  ENSCAFT00040043987.1 UniProtKB/TrEMBL
  ENSCAFT00845038728 ENTREZGENE
  ENSCAFT00845038728.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  GPR18 UniProtKB/TrEMBL
NCBI Gene GPR18 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24232:SF1 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C0LDL0 ENTREZGENE
  A0A8C0MFA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PH14 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41420 ENTREZGENE