OR2T2 (olfactory receptor family 2 subfamily T member 2)

Gene: OR2T2 (olfactory receptor family 2 subfamily T member 2) Canis lupus familiaris

Analyze

Symbol:

OR2T2

Name:

olfactory receptor family 2 subfamily T member 2

RGD ID:

12072731

Description:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cOR2T21; olfactory receptor 2T2; olfactory receptor, family 2, subfamily T, member 2; OR04B08

RGD Orthologs

Human

Bonobo

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	2,663,502 - 2,664,476 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	2,663,502 - 2,664,476 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	2,313,685 - 2,314,659 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	2,396,267 - 2,397,241 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	14	2,541,502 - 2,542,476 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	2,342,145 - 2,343,119 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	2,202,318 - 2,203,292 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 54 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of smell (IEA)

G protein-coupled receptor signaling pathway (IEA)

sensory perception of smell (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

olfactory receptor activity (IEA)

References

Additional References at PubMed

PMID:14659017	PMID:14962662	PMID:22301074

Genomics

Comparative Map Data

OR2T2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	2,663,502 - 2,664,476 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	2,663,502 - 2,664,476 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	2,313,685 - 2,314,659 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	2,396,267 - 2,397,241 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	14	2,541,502 - 2,542,476 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	2,342,145 - 2,343,119 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	2,202,318 - 2,203,292 (-)	NCBI		UU_Cfam_GSD_1.0

OR2T2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	248,445,637 - 248,455,725 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	248,445,512 - 248,455,725 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	248,608,938 - 248,619,026 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	246,682,722 - 246,683,696 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	244,942,139 - 244,943,114	NCBI
Celera	1	222,100,387 - 222,101,452 (-)	NCBI		Celera
Cytogenetic Map	1	q44	NCBI
HuRef	1	219,003,385 - 219,004,359 (+)	NCBI		HuRef
CHM1_1	1	249,888,263 - 249,889,237 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	247,890,321 - 247,900,427 (+)	NCBI		T2T-CHM13v2.0

LOC100969970
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	376,858 - 377,832 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	647,293 - 648,265 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	224,311,299 - 224,312,271 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	229,761,591 - 229,762,563 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

Variants

Variants in OR2T2
13 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	reproductive system
High
Medium
Low
Below cutoff	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038495253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038557533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038620330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038686015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_539359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ431415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY355804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000001957 ⟹ ENSCAFP00000001806

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	14	2,663,502 - 2,664,476 (+)	Ensembl

RefSeq Acc Id:

XM_038495253 ⟹ XP_038351181

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	14	2,541,502 - 2,542,476 (+)	NCBI

RefSeq Acc Id:

XM_038557533 ⟹ XP_038413461

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	14	2,202,318 - 2,203,292 (-)	NCBI

RefSeq Acc Id:

XM_038620330 ⟹ XP_038476258

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	14	2,342,145 - 2,343,119 (+)	NCBI

RefSeq Acc Id:

XM_038686015 ⟹ XP_038541943

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	14	2,396,267 - 2,397,241 (+)	NCBI

RefSeq Acc Id:

XM_539359 ⟹ XP_539359

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	14	2,663,502 - 2,664,476 (+)	NCBI
Dog10K_Boxer_Tasha	14	2,313,685 - 2,314,659 (+)	NCBI

Sequence:

show sequence

ATGAGCATGGAGGCCATTCTCCAGAACTCCACTGATTTTATCCTTCTGGGCCTTATCACCCATC
CTGCATTTCCTGGGATTATCTTTGCAGTGGTTTTCTCCATTTTTTTGGTGGCTGTCACAGCCAA
TGTGGTCATGATTCTACTCATCCATGTTAACTCTCGGCTCCATACACCCATGTACTTTTTACTC
AGCCAGCTTTCCATCATGGACACTGTTTACATTTGCATCACTGTTCCCAAGATGCTTCAAGACC
TTCTGTCCAAGGAAAAGATGATCTCCTTCTTGGGATGTTCCCTTCAGATCTTCCTCTACCTGAC
TCTAATTGGAGGTGAATTTTTCCTGCTAGGCCTCATGGCCTATGACCGGTATGTAGCTGTGTGC
AAACCCCTGCGATACCCTCTCCTCATGAACCGCAGAATTTGCTTATTCATGGTGGTGGGTTCCT
GGGTTGGTGGGTCCTTAGATGGATTCATGCTGACACCCTTTACTATGAGTTTCCCCTACTGTGG
GTCCCGAGAAATCAATCACTTTTTCTGTGAAATCCCAGCAGTACTGAAACTGTCATGTGTTGAC
ACATCACTCTATGAGACTCTGATGTATGCCTGCTGTGTGCTAATGCTGCTCATTCCCATATCCA
TTATCTCTATTTCCTACACACACATCCTACTCACTGTCCATCGAATGAACTCTGCTGAGGGCCG
GCATAAAGCCTTTGCTACCTGTTCTTCCCACATTATGGTGGTGAGCATTTTCTATGGAGCAGCC
TTCTACACTAATGTGCTGCCCCATTCCTACCACACACCAGAGAAAGACAAGGTTGTATCCGCCT
TCTATACCATCCTCACCCCAATGCTCAACCCACTCATCTACAGCTTGAGAAACAAAGATGTGGC
CACAGCTCTAAGAAAAGTGCTGGGGAGATGCCCCTCTTCTCAGAGAATAAGAGTGGTGGATTTG
TCCAGGAAATACTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_038351181	(Get FASTA)	NCBI Sequence Viewer
	XP_038413461	(Get FASTA)	NCBI Sequence Viewer
	XP_038476258	(Get FASTA)	NCBI Sequence Viewer
	XP_038541943	(Get FASTA)	NCBI Sequence Viewer
	XP_539359	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAD24124	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000001806.3
	ENSCAFP00030023694.1
	ENSCAFP00040008250.1
	ENSCAFP00040018707.1
	ENSCAFP00845020354
	ENSCAFP00845020354.1

RefSeq Acc Id:

XP_539359 ⟸ XM_539359

- UniProtKB:

A0A8P0S776 (UniProtKB/TrEMBL), A0A8C0QVQ3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSMEAILQNSTDFILLGLITHPAFPGIIFAVVFSIFLVAVTANVVMILLIHVNSRLHTPMYFLL
SQLSIMDTVYICITVPKMLQDLLSKEKMISFLGCSLQIFLYLTLIGGEFFLLGLMAYDRYVAVC
KPLRYPLLMNRRICLFMVVGSWVGGSLDGFMLTPFTMSFPYCGSREINHFFCEIPAVLKLSCVD
TSLYETLMYACCVLMLLIPISIISISYTHILLTVHRMNSAEGRHKAFATCSSHIMVVSIFYGAA
FYTNVLPHSYHTPEKDKVVSAFYTILTPMLNPLIYSLRNKDVATALRKVLGRCPSSQRIRVVDL
SRKY

hide sequence

RefSeq Acc Id:

ENSCAFP00000001806 ⟸ ENSCAFT00000001957

RefSeq Acc Id:

XP_038351181 ⟸ XM_038495253

RefSeq Acc Id:

XP_038476258 ⟸ XM_038620330

RefSeq Acc Id:	XP_038541943 ⟸ XM_038686015
- UniProtKB:	A0A8I3NNV7 (UniProtKB/TrEMBL), A0A8C0QVQ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038413461 ⟸ XM_038557533
- UniProtKB:	A0A8C0QVQ3 (UniProtKB/TrEMBL), A0A8P0S776 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001268	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030014718	UniProtKB/TrEMBL
	ENSCAFG00040005083	UniProtKB/TrEMBL
	ENSCAFG00040011682	UniProtKB/TrEMBL
	ENSCAFG00845014440	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000001957.4	UniProtKB/TrEMBL
	ENSCAFT00030027147.1	UniProtKB/TrEMBL
	ENSCAFT00040009518.1	UniProtKB/TrEMBL
	ENSCAFT00040021549.1	UniProtKB/TrEMBL
	ENSCAFT00845025831	ENTREZGENE
	ENSCAFT00845025831.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Olfact_rcpt	UniProtKB/TrEMBL
KEGG Report	cfa:482240	UniProtKB/TrEMBL
NCBI Gene	OR2T2	ENTREZGENE
PANTHER	OLFACTORY RECEPTOR	UniProtKB/TrEMBL
	OLFACTORY RECEPTOR 2T2-RELATED	UniProtKB/TrEMBL
Pfam	7tm_4	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	OLFACTORYR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A8C0QFZ9_CANLF	UniProtKB/TrEMBL
	A0A8C0QVQ3	ENTREZGENE
	A0A8I3NNV7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0S776	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:84671	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-01-14	OR2T2	olfactory receptor family 2 subfamily T member 2	OR2T2	olfactory receptor, family 2, subfamily T, member 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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