LAMB1 (laminin subunit beta 1) - Rat Genome Database

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Gene: LAMB1 (laminin subunit beta 1) Canis lupus familiaris
Analyze
Symbol: LAMB1
Name: laminin subunit beta 1
RGD ID: 12063435
Description: ENCODES a protein that exhibits enzyme binding (ortholog); glycosphingolipid binding (ortholog); integrin binding (ortholog); INVOLVED IN cell migration (ortholog); embryo implantation (ortholog); negative regulation of cell adhesion (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); Classical Lissencephalies and Subcortical Band Heterotopias (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); extracellular matrix (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: laminin subunit beta-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,634,640 - 12,700,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,630,554 - 12,700,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1812,273,909 - 12,344,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01812,901,205 - 12,971,843 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,886,065 - 13,160,390 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,719,649 - 12,788,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,639,931 - 12,709,079 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,866,134 - 12,936,827 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LAMB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,634,640 - 12,700,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,630,554 - 12,700,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1812,273,909 - 12,344,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01812,901,205 - 12,971,843 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,886,065 - 13,160,390 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,719,649 - 12,788,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,639,931 - 12,709,079 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,866,134 - 12,936,827 (+)NCBIUU_Cfam_GSD_1.0
LAMB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387107,923,799 - 108,003,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7107,923,799 - 108,003,213 (-)EnsemblGRCh38hg38GRCh38
GRCh377107,564,244 - 107,643,606 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367107,351,499 - 107,431,040 (-)NCBINCBI36Build 36hg18NCBI36
Build 347107,158,213 - 107,237,755NCBI
Celera7102,371,233 - 102,450,770 (-)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7101,926,690 - 102,006,298 (-)NCBIHuRef
CHM1_17107,497,967 - 107,577,516 (-)NCBICHM1_1
T2T-CHM13v2.07109,241,996 - 109,321,407 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27106,925,375 - 107,004,933 (-)NCBI
Lamb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391231,315,230 - 31,379,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1231,315,233 - 31,379,643 (+)EnsemblGRCm39 Ensembl
GRCm381231,265,146 - 31,329,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,265,234 - 31,329,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv371231,950,159 - 32,014,504 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361231,851,443 - 31,915,700 (+)NCBIMGSCv36mm8
Celera1232,713,386 - 32,777,732 (+)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.39NCBI
Lamb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8653,562,849 - 53,630,118 (+)NCBIGRCr8
mRatBN7.2647,835,492 - 47,902,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl647,835,525 - 47,902,585 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0650,528,796 - 50,596,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl650,528,823 - 50,596,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,204,031 - 59,271,336 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,115,671 - 49,183,374 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1649,109,263 - 49,186,072 (+)NCBI
Celera647,038,296 - 47,105,077 (+)NCBICelera
Cytogenetic Map6q16NCBI
Lamb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541012,241,235 - 12,305,433 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541012,241,235 - 12,305,433 (-)NCBIChiLan1.0ChiLan1.0
LAMB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26144,769,878 - 144,849,511 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17193,039,847 - 193,120,895 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0799,905,761 - 99,985,233 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17112,627,488 - 112,706,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7112,627,488 - 112,706,554 (-)Ensemblpanpan1.1panPan2
Lamb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,053,363 - 55,121,513 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647916,177,158 - 16,247,165 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647916,177,200 - 16,245,268 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9107,671,152 - 107,772,269 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19107,670,120 - 107,747,242 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29118,440,049 - 118,515,695 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12176,829,287 - 76,914,348 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2176,829,443 - 76,914,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604226,949,313 - 27,034,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473921,771,226 - 21,843,884 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473921,771,617 - 21,843,888 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LAMB1
789 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 6 6 12 10 6
Low 6 6 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006148   ⟹   ENSCAFP00000005692
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1812,637,547 - 12,700,308 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087385   ⟹   ENSCAFP00000049135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1812,630,554 - 12,700,308 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042116   ⟹   ENSCAFP00845033030
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1812,886,065 - 13,160,390 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042463   ⟹   ENSCAFP00845033287
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1812,886,065 - 12,971,790 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042652   ⟹   ENSCAFP00845033445
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1812,898,441 - 12,971,837 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845042988   ⟹   ENSCAFP00845033702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1812,901,558 - 12,971,837 (+)Ensembl
RefSeq Acc Id: XM_014120760   ⟹   XP_013976235
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11812,634,640 - 12,700,311 (+)NCBI
Dog10K_Boxer_Tasha1812,275,372 - 12,344,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038423774   ⟹   XP_038279702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01812,901,205 - 12,971,695 (+)NCBI
RefSeq Acc Id: XM_038423775   ⟹   XP_038279703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01812,902,672 - 12,971,843 (+)NCBI
RefSeq Acc Id: XM_038454405   ⟹   XP_038310333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1812,273,909 - 12,344,396 (+)NCBI
RefSeq Acc Id: XM_038500129   ⟹   XP_038356057
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11812,719,649 - 12,788,770 (+)NCBI
RefSeq Acc Id: XM_038562689   ⟹   XP_038418617
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01812,866,134 - 12,936,679 (+)NCBI
RefSeq Acc Id: XM_038562690   ⟹   XP_038418618
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01812,867,603 - 12,936,827 (+)NCBI
RefSeq Acc Id: XM_038626802   ⟹   XP_038482730
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01812,639,931 - 12,709,079 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013976235   ⟸   XM_014120760
- UniProtKB: A0A8C0YWX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005692   ⟸   ENSCAFT00000006148
RefSeq Acc Id: ENSCAFP00000049135   ⟸   ENSCAFT00000087385
RefSeq Acc Id: XP_038356057   ⟸   XM_038500129
RefSeq Acc Id: XP_038482730   ⟸   XM_038626802
RefSeq Acc Id: XP_038279702   ⟸   XM_038423774
- UniProtKB: A0A8C0YWX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279703   ⟸   XM_038423775
- UniProtKB: A0A8C0YWX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310333   ⟸   XM_038454405
- UniProtKB: A0A8C0YWX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418617   ⟸   XM_038562689
- UniProtKB: A0A8C0YWX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418618   ⟸   XM_038562690
- UniProtKB: A0A8C0YWX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033445   ⟸   ENSCAFT00845042652
RefSeq Acc Id: ENSCAFP00845033702   ⟸   ENSCAFT00845042988
RefSeq Acc Id: ENSCAFP00845033287   ⟸   ENSCAFT00845042463
RefSeq Acc Id: ENSCAFP00845033030   ⟸   ENSCAFT00845042116
Protein Domains
Laminin EGF-like   Laminin IV type B   Laminin N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025057 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021750 UniProtKB/TrEMBL
  ENSCAFG00040012493 UniProtKB/TrEMBL
  ENSCAFG00845023838 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006148.5 UniProtKB/TrEMBL
  ENSCAFT00000087385.2 UniProtKB/TrEMBL
  ENSCAFT00000098504.1 UniProtKB/TrEMBL
  ENSCAFT00000102711.1 UniProtKB/TrEMBL
  ENSCAFT00030039900.1 UniProtKB/TrEMBL
  ENSCAFT00030040010.1 UniProtKB/TrEMBL
  ENSCAFT00030040144.1 UniProtKB/TrEMBL
  ENSCAFT00040023062.1 UniProtKB/TrEMBL
  ENSCAFT00845042116 ENTREZGENE
  ENSCAFT00845042116.1 UniProtKB/TrEMBL
  ENSCAFT00845042463.1 UniProtKB/TrEMBL
  ENSCAFT00845042652 ENTREZGENE
  ENSCAFT00845042652.1 UniProtKB/TrEMBL
  ENSCAFT00845042988.1 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_IV_B UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
NCBI Gene LAMB1 ENTREZGENE
PANTHER LAMININ SUBUNIT BETA-1 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
Pfam Laminin_EGF UniProtKB/TrEMBL
  LAMININ_IV_B UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  LAMININ_IVB UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  LamNT UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A8C0PD38_CANLF UniProtKB/TrEMBL
  A0A8C0PDD2_CANLF UniProtKB/TrEMBL
  A0A8C0PGS7_CANLF UniProtKB/TrEMBL
  A0A8C0YWX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PH89_CANLF UniProtKB/TrEMBL
  A0A8I3PKU7_CANLF UniProtKB/TrEMBL
  A0A8I3PL58_CANLF UniProtKB/TrEMBL
  A0A8I3S7R9_CANLF UniProtKB/TrEMBL
  A0A8P0N6M8_CANLF UniProtKB/TrEMBL
  A0A8P0NZ53_CANLF UniProtKB/TrEMBL
  A0A8P0TMZ1_CANLF UniProtKB/TrEMBL
  A0A8P0TQI0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42567 ENTREZGENE