CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2) - Rat Genome Database

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Gene: CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2) Canis lupus familiaris
Analyze
Symbol: CHCHD2
Name: coiled-coil-helix-coiled-coil-helix domain containing 2
RGD ID: 12062598
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (inferred); sequence-specific DNA binding (inferred); INVOLVED IN cellular response to oxidative stress (inferred); mitochondrion organization (inferred); positive regulation of mitochondrial ATP synthesis coupled electron transport (inferred); ASSOCIATED WITH amelogenesis imperfecta (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial intermembrane space (inferred); mitochondrion (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: coiled-coil-helix-coiled-coil-helix domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16581,276 - 585,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6581,280 - 585,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,280,745 - 2,284,839 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06385,111 - 389,203 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6385,115 - 389,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16328,861 - 332,963 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06322,956 - 327,041 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06494,144 - 498,243 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CHCHD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16581,276 - 585,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6581,280 - 585,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,280,745 - 2,284,839 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06385,111 - 389,203 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6385,115 - 389,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16328,861 - 332,963 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06322,956 - 327,041 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06494,144 - 498,243 (-)NCBIUU_Cfam_GSD_1.0
CHCHD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38756,101,573 - 56,106,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl756,101,573 - 56,106,476 (-)EnsemblGRCh38hg38GRCh38
GRCh37756,169,266 - 56,174,169 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36756,136,760 - 56,141,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 34755,943,476 - 55,948,396NCBI
Celera767,222,175 - 67,227,096 (-)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,983,486 - 55,988,171 (-)NCBIHuRef
CHM1_1756,172,294 - 56,177,215 (-)NCBICHM1_1
T2T-CHM13v2.0756,261,388 - 56,266,291 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2756,173,513 - 56,178,434 (-)NCBI
Chchd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,910,002 - 129,916,311 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,909,997 - 129,916,311 (-)EnsemblGRCm39 Ensembl
GRCm385129,881,161 - 129,887,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,881,156 - 129,887,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,357,032 - 130,363,340 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,165,865 - 130,172,173 (-)NCBIMGSCv36mm8
Celera5126,880,556 - 126,886,855 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.26NCBI
Chchd2l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,947,769 - 101,948,440 (-)NCBIGRCr8
mRatBN7.2994,500,439 - 94,501,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,500,432 - 94,501,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,935,898 - 102,936,569 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09108,071,025 - 108,071,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,427,988 - 106,428,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09101,388,148 - 101,388,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09101,018,487 - 101,019,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.09101,018,677 - 101,019,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4927,858,760 - 28,053,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.4993,253,912 - 93,254,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,460,637 - 93,461,304 (-)NCBI
Celera992,034,380 - 92,035,051 (-)NCBICelera
Cytogenetic Map9q36NCBI
Chchd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,255,898 - 8,265,488 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,260,533 - 8,265,488 (-)NCBIChiLan1.0ChiLan1.0
CHCHD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,953,733 - 60,958,902 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17109,278,455 - 109,283,547 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0756,714,583 - 56,719,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1757,136,723 - 57,141,765 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl757,134,303 - 57,141,765 (-)Ensemblpanpan1.1panPan2
Chchd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,172,517 - 126,175,918 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,860,448 - 7,863,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,860,432 - 7,864,050 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHCHD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,812,404 - 16,819,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,812,409 - 16,819,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,065,147 - 17,071,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHCHD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1212,675,522 - 2,680,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041179,877,669 - 179,882,552 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chchd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,278,078 - 8,283,657 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247408,279,416 - 8,283,730 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CHCHD2
46 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016162   ⟹   ENSCAFP00000014948
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl6581,280 - 585,301 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845023424   ⟹   ENSCAFP00845018381
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl6385,115 - 389,137 (-)Ensembl
RefSeq Acc Id: XM_038477737   ⟹   XP_038333665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.16328,861 - 332,963 (-)NCBI
RefSeq Acc Id: XM_038538984   ⟹   XP_038394912
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.06494,144 - 498,243 (-)NCBI
RefSeq Acc Id: XM_038603079   ⟹   XP_038459007
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.06322,956 - 327,041 (-)NCBI
RefSeq Acc Id: XM_038667784   ⟹   XP_038523712
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.06385,111 - 389,203 (-)NCBI
RefSeq Acc Id: XM_536830   ⟹   XP_536830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.16581,276 - 585,367 (-)NCBI
Dog10K_Boxer_Tasha62,280,745 - 2,284,839 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_536830   ⟸   XM_536830
- UniProtKB: A0A8C0LV97 (UniProtKB/TrEMBL),   A0A8I3RXD6 (UniProtKB/TrEMBL),   A0A8C0JUD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014948   ⟸   ENSCAFT00000016162
RefSeq Acc Id: XP_038333665   ⟸   XM_038477737
RefSeq Acc Id: XP_038459007   ⟸   XM_038603079
RefSeq Acc Id: XP_038523712   ⟸   XM_038667784
- UniProtKB: A0A8C0LV97 (UniProtKB/TrEMBL),   A0A8I3RXD6 (UniProtKB/TrEMBL),   A0A8C0JUD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394912   ⟸   XM_038538984
- UniProtKB: A0A8C0JUD1 (UniProtKB/TrEMBL),   A0A8C0LV97 (UniProtKB/TrEMBL),   A0A8I3RXD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845018381   ⟸   ENSCAFT00845023424
Protein Domains
CHCH

Promoters
RGD ID:13683492
Promoter ID:EPDNEW_C1561
Type:initiation region
Name:CHCHD2_1
Description:coiled-coil-helix-coiled-coil-helix domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.16585,301 - 585,361EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010178 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000624 UniProtKB/TrEMBL
  ENSCAFG00040005918 UniProtKB/TrEMBL
  ENSCAFG00845013155 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016162.5 UniProtKB/TrEMBL
  ENSCAFT00030001013.1 UniProtKB/TrEMBL
  ENSCAFT00040011065.1 UniProtKB/TrEMBL
  ENSCAFT00845023424 ENTREZGENE
  ENSCAFT00845023424.1 UniProtKB/TrEMBL
InterPro CHCH UniProtKB/TrEMBL
KEGG Report cfa:479702 UniProtKB/TrEMBL
NCBI Gene CHCHD2 ENTREZGENE
PANTHER COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77 UniProtKB/TrEMBL
  COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam CHCH UniProtKB/TrEMBL
PROSITE CHCH UniProtKB/TrEMBL
UniProt A0A8C0JUD1 ENTREZGENE
  A0A8C0LV97 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RXD6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54011 ENTREZGENE