TXNDC12 (thioredoxin domain containing 12) - Rat Genome Database

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Gene: TXNDC12 (thioredoxin domain containing 12) Canis lupus familiaris
Analyze
Symbol: TXNDC12
Name: thioredoxin domain containing 12 (Ensembl:RAB3B, member RAS oncogene family)
RGD ID: 12062123
Description: ENCODES a protein that exhibits protein-disulfide reductase (glutathione) activity (ortholog); protein-disulfide reductase activity (ortholog); INVOLVED IN negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thioredoxin domain-containing protein 12; thioredoxin domain-containing protein 12-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,261,493 - 9,292,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,262,004 - 9,291,553 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,414,248 - 9,444,245 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,386,745 - 9,416,751 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,386,741 - 9,503,119 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,197,412 - 9,227,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,286,920 - 9,316,775 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,304,316 - 9,334,308 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TXNDC12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,261,493 - 9,292,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,262,004 - 9,291,553 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,414,248 - 9,444,245 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,386,745 - 9,416,751 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,386,741 - 9,503,119 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,197,412 - 9,227,390 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,286,920 - 9,316,775 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,304,316 - 9,334,308 (+)NCBIUU_Cfam_GSD_1.0
TXNDC12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38152,020,131 - 52,056,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl152,020,131 - 52,055,191 (-)EnsemblGRCh38hg38GRCh38
GRCh37152,485,803 - 52,521,843 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36152,258,391 - 52,293,635 (-)NCBINCBI36Build 36hg18NCBI36
Celera150,773,286 - 50,808,524 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,603,209 - 50,639,242 (-)NCBIHuRef
CHM1_1152,603,297 - 52,639,345 (-)NCBICHM1_1
T2T-CHM13v2.0151,901,645 - 51,937,676 (-)NCBIT2T-CHM13v2.0
Txndc12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,691,875 - 108,719,317 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,691,798 - 108,719,324 (+)EnsemblGRCm39 Ensembl
GRCm384108,834,678 - 108,862,120 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4108,834,601 - 108,862,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,507,283 - 108,534,725 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,332,610 - 108,360,052 (+)NCBIMGSCv36mm8
Celera4107,172,837 - 107,199,896 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.64NCBI
Txndc12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,815,471 - 128,841,574 (+)NCBIGRCr8
mRatBN7.25123,587,854 - 123,612,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,586,781 - 123,612,870 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,210,642 - 126,235,652 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,933,744 - 127,958,758 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05127,985,034 - 128,010,042 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,450,830 - 128,475,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,450,680 - 128,475,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,291,196 - 132,316,224 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45130,142,600 - 130,167,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15130,147,623 - 130,172,855 (+)NCBI
Celera5122,322,074 - 122,347,022 (+)NCBICelera
Cytogenetic Map5q34NCBI
Txndc12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,070,555 - 7,094,981 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554647,070,555 - 7,094,991 (+)NCBIChiLan1.0ChiLan1.0
TXNDC12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21174,803,916 - 174,840,151 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11173,946,705 - 173,981,702 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,271,206 - 51,307,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1152,875,130 - 52,911,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl152,875,130 - 52,911,051 (-)Ensemblpanpan1.1panPan2
Txndc12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505866,514,852 - 66,607,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365228,877,826 - 8,903,110 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365228,877,832 - 8,900,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNDC12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6160,137,018 - 160,168,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16160,136,744 - 160,168,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26147,852,519 - 147,870,966 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXNDC12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12080,894,151 - 80,929,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2080,895,228 - 80,929,704 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603336,341,887 - 36,377,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txndc12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248591,137,563 - 1,162,766 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248591,137,428 - 1,160,502 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TXNDC12
388 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000044217   ⟹   ENSCAFP00000039403
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl159,262,049 - 9,291,553 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087256   ⟹   ENSCAFP00000062571
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl159,262,004 - 9,278,097 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845037292   ⟹   ENSCAFP00845029209
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl159,386,741 - 9,402,839 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845037322   ⟹   ENSCAFP00845029232
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl159,386,761 - 9,416,747 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845037390   ⟹   ENSCAFP00845029289
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl159,386,775 - 9,500,791 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845037445   ⟹   ENSCAFP00845029336
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl159,386,804 - 9,500,791 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845037513   ⟹   ENSCAFP00845029391
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl159,386,809 - 9,503,119 (+)Ensembl
RefSeq Acc Id: XM_038495674   ⟹   XP_038351602
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1159,197,412 - 9,227,390 (+)NCBI
RefSeq Acc Id: XM_038558036   ⟹   XP_038413964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0159,304,316 - 9,334,308 (+)NCBI
RefSeq Acc Id: XM_038621905   ⟹   XP_038477833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0159,286,920 - 9,316,775 (+)NCBI
RefSeq Acc Id: XM_038687663   ⟹   XP_038543591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0159,386,745 - 9,416,751 (+)NCBI
RefSeq Acc Id: XM_847187   ⟹   XP_852280
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1159,262,009 - 9,292,097 (+)NCBI
Dog10K_Boxer_Tasha159,414,248 - 9,444,245 (+)NCBI
Sequence:
RefSeq Acc Id: XP_852280   ⟸   XM_847187
- UniProtKB: A0A8C0QRG8 (UniProtKB/TrEMBL),   A0A8C0QYV3 (UniProtKB/TrEMBL),   A0A8I3PAB3 (UniProtKB/TrEMBL),   A0A8C0RHT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000062571   ⟸   ENSCAFT00000087256
RefSeq Acc Id: ENSCAFP00000039403   ⟸   ENSCAFT00000044217
RefSeq Acc Id: XP_038351602   ⟸   XM_038495674
RefSeq Acc Id: XP_038477833   ⟸   XM_038621905
RefSeq Acc Id: XP_038543591   ⟸   XM_038687663
- UniProtKB: A0A8C0QRG8 (UniProtKB/TrEMBL),   A0A8C0QYV3 (UniProtKB/TrEMBL),   A0A8I3PAB3 (UniProtKB/TrEMBL),   A0A8C0RHT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038413964   ⟸   XM_038558036
- UniProtKB: A0A8C0QRG8 (UniProtKB/TrEMBL),   A0A8C0QYV3 (UniProtKB/TrEMBL),   A0A8C0RHT7 (UniProtKB/TrEMBL),   A0A8I3PAB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845029232   ⟸   ENSCAFT00845037322
RefSeq Acc Id: ENSCAFP00845029336   ⟸   ENSCAFT00845037445
RefSeq Acc Id: ENSCAFP00845029209   ⟸   ENSCAFT00845037292
RefSeq Acc Id: ENSCAFP00845029289   ⟸   ENSCAFT00845037390
RefSeq Acc Id: ENSCAFP00845029391   ⟸   ENSCAFT00845037513
Protein Domains
Thioredoxin

Promoters
RGD ID:13685883
Promoter ID:EPDNEW_C3951
Type:initiation region
Name:TXNDC12_1
Description:thioredoxin domain containing 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1159,262,030 - 9,262,090EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029215 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011340 UniProtKB/TrEMBL
  ENSCAFG00040008380 UniProtKB/TrEMBL
  ENSCAFG00845021135 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039721.4 UniProtKB/TrEMBL
  ENSCAFT00000044217.3 UniProtKB/TrEMBL
  ENSCAFT00000087256.2 UniProtKB/TrEMBL
  ENSCAFT00000100740.1 UniProtKB/TrEMBL
  ENSCAFT00000101101.1 UniProtKB/TrEMBL
  ENSCAFT00030021097.1 UniProtKB/TrEMBL
  ENSCAFT00040015643.1 UniProtKB/TrEMBL
  ENSCAFT00845037292.1 UniProtKB/TrEMBL
  ENSCAFT00845037322 ENTREZGENE
  ENSCAFT00845037322.1 UniProtKB/TrEMBL
  ENSCAFT00845037390.1 UniProtKB/TrEMBL
  ENSCAFT00845037445.1 UniProtKB/TrEMBL
  ENSCAFT00845037513.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro ERp19 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Rab3 UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report cfa:609843 UniProtKB/TrEMBL
NCBI Gene TXNDC12 ENTREZGENE
PANTHER ANTERIOR GRADIENT PROTEIN-RELATED UniProtKB/TrEMBL
  LD44762P UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-3B UniProtKB/TrEMBL
  THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
  Thioredoxin_7 UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
  THIOREDOXIN_1 UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0QRG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QYV3 ENTREZGENE
  A0A8C0RHT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P782_CANLF UniProtKB/TrEMBL
  A0A8I3PAB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PF48_CANLF UniProtKB/TrEMBL
  A0A8I3PG06_CANLF UniProtKB/TrEMBL
  A0A8I3S4T4_CANLF UniProtKB/TrEMBL
  A0A8P0NN40_CANLF UniProtKB/TrEMBL
  A0A8P0NQU7_CANLF UniProtKB/TrEMBL
  A0A8P0TE51_CANLF UniProtKB/TrEMBL
  A0A8P0TKJ9_CANLF UniProtKB/TrEMBL
  A0A8P0TRV1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48011 ENTREZGENE