PLCL1 (phospholipase C like 1 (inactive)) - Rat Genome Database

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Gene: PLCL1 (phospholipase C like 1 (inactive)) Canis lupus familiaris
Analyze
Symbol: PLCL1
Name: phospholipase C like 1 (inactive)
RGD ID: 12059365
Description: ENCODES a protein that exhibits GABA receptor binding (ortholog); INVOLVED IN gamma-aminobutyric acid signaling pathway (ortholog); regulation of synaptic transmission, GABAergic (ortholog); ASSOCIATED WITH Experimental Liver Neoplasms (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inactive phospholipase C-like protein 1; phospholipase C like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,235,403 - 7,575,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl377,235,424 - 7,562,708 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha378,181,566 - 8,509,686 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0377,125,882 - 7,454,891 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl377,125,882 - 7,455,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1377,124,391 - 7,452,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0377,090,950 - 7,418,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0377,115,313 - 7,444,018 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLCL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,235,403 - 7,575,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl377,235,424 - 7,562,708 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha378,181,566 - 8,509,686 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0377,125,882 - 7,454,891 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl377,125,882 - 7,455,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1377,124,391 - 7,452,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0377,090,950 - 7,418,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0377,115,313 - 7,444,018 (+)NCBIUU_Cfam_GSD_1.0
PLCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382197,804,593 - 198,149,863 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2197,804,593 - 198,572,581 (+)EnsemblGRCh38hg38GRCh38
GRCh372198,669,317 - 199,014,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,539,545 - 198,721,293 (+)NCBINCBI36Build 36hg18NCBI36
Build 342198,656,805 - 198,838,554NCBI
Celera2192,425,193 - 192,770,374 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2190,521,603 - 190,866,928 (+)NCBIHuRef
CHM1_12198,675,428 - 199,020,595 (+)NCBICHM1_1
T2T-CHM13v2.02198,288,252 - 198,633,649 (+)NCBIT2T-CHM13v2.0
Plcl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,442,722 - 55,793,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,445,080 - 55,793,444 (+)EnsemblGRCm39 Ensembl
GRCm38155,405,946 - 55,754,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,405,921 - 55,754,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,462,790 - 55,811,129 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,653,237 - 56,014,883 (+)NCBIMGSCv36mm8
Celera155,926,260 - 56,273,512 (+)NCBICelera
Cytogenetic Map1C1.2NCBI
cM Map128.15NCBI
Plcl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8964,395,976 - 64,733,171 (+)NCBIGRCr8
mRatBN7.2956,901,573 - 57,238,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl956,901,534 - 57,238,782 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx965,406,716 - 65,743,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0970,522,633 - 70,859,895 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0968,828,156 - 69,179,166 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0962,016,112 - 62,349,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl962,291,405 - 62,349,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,824,561 - 62,158,071 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4954,207,542 - 54,546,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1954,335,647 - 54,676,737 (+)NCBI
Celera954,380,510 - 54,712,666 (+)NCBICelera
Cytogenetic Map9q31NCBI
Plcl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554032,641,360 - 2,693,352 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554032,643,092 - 2,904,651 (-)NCBIChiLan1.0ChiLan1.0
PLCL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213100,423,115 - 100,771,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B100,438,108 - 100,786,717 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B85,054,907 - 85,397,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B202,947,931 - 203,286,656 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,947,927 - 203,286,649 (+)Ensemblpanpan1.1panPan2
Plcl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303155,380,223 - 155,713,949 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365061,125,806 - 1,457,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365061,124,318 - 1,457,842 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,840,806 - 101,951,106 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,602,336 - 102,424,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,689,632 - 113,486,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11083,291,683 - 83,640,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1083,574,894 - 83,642,768 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040115,809,308 - 116,157,731 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248892,271,043 - 2,559,396 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248892,225,082 - 2,559,379 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLCL1
3843 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 2 2 6 7
Low 5 3 20 6 4 6 6 5 8 10 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005640502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038447512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038585269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038649675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_536020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000017444   ⟹   ENSCAFP00000016153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl377,235,424 - 7,562,708 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048724   ⟹   ENSCAFP00845038228
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl377,125,882 - 7,455,347 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048750   ⟹   ENSCAFP00845038249
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl377,199,828 - 7,455,347 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048788   ⟹   ENSCAFP00845038279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl377,380,236 - 7,455,347 (+)Ensembl
RefSeq Acc Id: XM_005640502   ⟹   XP_005640559
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1377,489,534 - 7,563,887 (+)NCBI
Dog10K_Boxer_Tasha378,435,354 - 8,509,686 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038447511   ⟹   XP_038303439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0377,125,882 - 7,454,891 (+)NCBI
RefSeq Acc Id: XM_038447512   ⟹   XP_038303440
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0377,380,395 - 7,454,891 (+)NCBI
RefSeq Acc Id: XM_038521572   ⟹   XP_038377500
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1377,124,391 - 7,452,882 (+)NCBI
RefSeq Acc Id: XM_038521573   ⟹   XP_038377501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1377,378,506 - 7,452,882 (+)NCBI
RefSeq Acc Id: XM_038585268   ⟹   XP_038441196
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0377,115,313 - 7,444,018 (+)NCBI
RefSeq Acc Id: XM_038585269   ⟹   XP_038441197
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0377,369,629 - 7,444,018 (+)NCBI
RefSeq Acc Id: XM_038649674   ⟹   XP_038505602
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0377,090,950 - 7,418,634 (+)NCBI
RefSeq Acc Id: XM_038649675   ⟹   XP_038505603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0377,344,457 - 7,418,634 (+)NCBI
RefSeq Acc Id: XM_536020   ⟹   XP_536020
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1377,235,409 - 7,563,887 (+)NCBI
Dog10K_Boxer_Tasha378,181,566 - 8,509,686 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_536020   ⟸   XM_536020
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N4W6 (UniProtKB/TrEMBL),   A0A8I3Q2C4 (UniProtKB/TrEMBL),   A0A8P0TST6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005640559   ⟸   XM_005640502
- Peptide Label: isoform X2
- UniProtKB: A0A8I3PYC3 (UniProtKB/TrEMBL),   A0A8C0QVF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016153   ⟸   ENSCAFT00000017444
RefSeq Acc Id: XP_038377500   ⟸   XM_038521572
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038377501   ⟸   XM_038521573
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038505602   ⟸   XM_038649674
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038505603   ⟸   XM_038649675
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038303439   ⟸   XM_038447511
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N4W6 (UniProtKB/TrEMBL),   A0A8I3Q2C4 (UniProtKB/TrEMBL),   A0A8P0TST6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038303440   ⟸   XM_038447512
- Peptide Label: isoform X2
- UniProtKB: A0A8I3PYC3 (UniProtKB/TrEMBL),   A0A8C0QVF5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441196   ⟸   XM_038585268
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N4W6 (UniProtKB/TrEMBL),   A0A8I3Q2C4 (UniProtKB/TrEMBL),   A0A8P0TST6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441197   ⟸   XM_038585269
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QVF5 (UniProtKB/TrEMBL),   A0A8I3PYC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038249   ⟸   ENSCAFT00845048750
RefSeq Acc Id: ENSCAFP00845038228   ⟸   ENSCAFT00845048724
RefSeq Acc Id: ENSCAFP00845038279   ⟸   ENSCAFT00845048788
Protein Domains
C2   PH   PI-PLC Y-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010953 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009789 UniProtKB/TrEMBL
  ENSCAFG00040021943 UniProtKB/TrEMBL
  ENSCAFG00845027611 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017444.5 UniProtKB/TrEMBL
  ENSCAFT00000097776.1 UniProtKB/TrEMBL
  ENSCAFT00000099699.1 UniProtKB/TrEMBL
  ENSCAFT00000101740.1 UniProtKB/TrEMBL
  ENSCAFT00030018181.1 UniProtKB/TrEMBL
  ENSCAFT00040040812.1 UniProtKB/TrEMBL
  ENSCAFT00040040835.1 UniProtKB/TrEMBL
  ENSCAFT00845048724 ENTREZGENE
  ENSCAFT00845048724.1 UniProtKB/TrEMBL
  ENSCAFT00845048750.1 UniProtKB/TrEMBL
  ENSCAFT00845048788 ENTREZGENE
  ENSCAFT00845048788.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
KEGG Report cfa:478858 UniProtKB/TrEMBL
NCBI Gene PLCL1 ENTREZGENE
PANTHER PTHR10336 UniProtKB/TrEMBL
  PTHR10336:SF102 UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PH_12 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
UniProt A0A8C0N4W6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QVF5 ENTREZGENE
  A0A8C0THJ3_CANLF UniProtKB/TrEMBL
  A0A8I3PYC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q2C4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S6E2_CANLF UniProtKB/TrEMBL
  A0A8P0ND03_CANLF UniProtKB/TrEMBL
  A0A8P0PJU5_CANLF UniProtKB/TrEMBL
  A0A8P0TST6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:56162 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-16 PLCL1  phospholipase C like 1 (inactive)    phospholipase C like 1  Symbol and/or name change 5135510 APPROVED