SDHB (succinate dehydrogenase complex iron sulfur subunit B) - Rat Genome Database

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Gene: SDHB (succinate dehydrogenase complex iron sulfur subunit B) Canis lupus familiaris
Analyze
Symbol: SDHB
Name: succinate dehydrogenase complex iron sulfur subunit B
RGD ID: 12055679
Description: ENCODES a protein that exhibits succinate dehydrogenase (quinone) activity (ortholog); ubiquinone binding (ortholog); INVOLVED IN respiratory electron transport chain (ortholog); succinate metabolic process (ortholog); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; electron transport chain pathway; ASSOCIATED WITH acute myocardial infarction (ortholog); Bannayan-Riley-Ruvalcaba syndrome (ortholog); bilateral breast cancer (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC608210  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,158,291 - 81,190,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,158,291 - 81,190,109 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,695,312 - 77,727,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,804,258 - 81,836,607 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,804,258 - 81,836,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,557,290 - 78,589,612 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,574,320 - 79,606,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0280,642,748 - 80,674,635 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References
Additional References at PubMed
PMID:16751257   PMID:22301074   PMID:24813157   PMID:30032202  


Genomics

Comparative Map Data
SDHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,158,291 - 81,190,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,158,291 - 81,190,109 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,695,312 - 77,727,188 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,804,258 - 81,836,607 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,804,258 - 81,836,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,557,290 - 78,589,612 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,574,320 - 79,606,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0280,642,748 - 80,674,635 (+)NCBIUU_Cfam_GSD_1.0
SDHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38117,018,722 - 17,054,032 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl117,018,664 - 17,054,032 (-)EnsemblGRCh38hg38GRCh38
GRCh37117,345,217 - 17,380,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36117,217,804 - 17,253,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34117,090,558 - 17,125,952NCBI
Celera115,667,559 - 15,703,013 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef115,589,311 - 15,624,677 (-)NCBIHuRef
CHM1_1117,453,561 - 17,489,010 (-)NCBICHM1_1
T2T-CHM13v2.0116,829,151 - 16,864,469 (-)NCBIT2T-CHM13v2.0
Sdhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394140,688,582 - 140,706,509 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4140,688,514 - 140,706,504 (+)EnsemblGRCm39 Ensembl
GRCm384140,961,271 - 140,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4140,961,203 - 140,979,193 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,517,186 - 140,535,108 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,233,347 - 140,251,269 (+)NCBIMGSCv36mm8
Celera4142,761,706 - 142,779,666 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.24NCBI
Sdhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,547,775 - 158,568,589 (+)NCBIGRCr8
mRatBN7.25153,264,906 - 153,285,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,264,899 - 153,314,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5155,953,279 - 155,973,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05157,726,549 - 157,747,081 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05157,715,729 - 157,736,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,484,378 - 159,505,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,484,370 - 159,505,064 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,197,045 - 163,217,315 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45159,818,669 - 159,839,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15159,828,844 - 159,849,873 (+)NCBI
Celera5151,629,862 - 151,650,475 (+)NCBICelera
Cytogenetic Map5q36NCBI
Sdhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555271,768,940 - 1,792,361 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555271,769,280 - 1,792,496 (+)NCBIChiLan1.0ChiLan1.0
SDHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,076,010 - 210,111,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11209,194,917 - 209,230,579 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,962,383 - 15,998,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1117,018,531 - 17,054,509 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl117,018,542 - 17,054,509 (-)Ensemblpanpan1.1panPan2
Sdhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505838,168,442 - 38,196,545 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,990,778 - 4,021,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,993,224 - 4,021,359 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,648,215 - 75,678,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,648,362 - 75,678,111 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,991,035 - 70,021,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SDHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120115,537,880 - 115,571,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20115,538,026 - 115,571,142 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666033549,592 - 583,182 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,650,604 - 2,679,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,655,138 - 2,679,138 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SDHB
455 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000025080   ⟹   ENSCAFP00000023278
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl281,158,291 - 81,190,109 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007599   ⟹   ENSCAFP00845006004
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl281,804,258 - 81,836,606 (+)Ensembl
RefSeq Acc Id: NM_001252217   ⟹   NP_001239146
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1281,158,291 - 81,190,110 (+)NCBI
Dog10K_Boxer_Tasha277,695,312 - 77,727,188 (+)NCBI
ROS_Cfam_1.0281,804,258 - 81,836,607 (+)NCBI
UMICH_Zoey_3.1278,557,290 - 78,589,612 (+)NCBI
UNSW_CanFamBas_1.0279,574,320 - 79,606,173 (+)NCBI
UU_Cfam_GSD_1.0280,642,748 - 80,674,635 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001239146 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABD77143 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000023278.3
  ENSCAFP00000057989.1
  ENSCAFP00030014127.1
  ENSCAFP00030017540.1
  ENSCAFP00040003436.1
  ENSCAFP00845006004
  ENSCAFP00845006004.1
  ENSCAFP00845021700.1
Reference Protein Sequences
RefSeq Acc Id: NP_001239146   ⟸   NM_001252217
- UniProtKB: A0A8C0RFS0 (UniProtKB/TrEMBL),   A0A8I3MX02 (UniProtKB/TrEMBL),   A0A8C0N0V5 (UniProtKB/TrEMBL),   A0A8I3S1H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023278   ⟸   ENSCAFT00000025080
RefSeq Acc Id: ENSCAFP00845006004   ⟸   ENSCAFT00845007599
Protein Domains
2Fe-2S ferredoxin-type   4Fe-4S ferredoxin-type

Promoters
RGD ID:13682637
Promoter ID:EPDNEW_C706
Type:initiation region
Name:SDHB_1
Description:succinate dehydrogenase complex iron sulfur subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1281,158,298 - 81,158,358EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001397 UniProtKB/TrEMBL
  ENSCAFG00000015832 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008760 UniProtKB/TrEMBL
  ENSCAFG00030010877 UniProtKB/TrEMBL
  ENSCAFG00040002110 UniProtKB/TrEMBL
  ENSCAFG00845004232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFG00845015476 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002161.3 UniProtKB/TrEMBL
  ENSCAFT00000025080.5 UniProtKB/TrEMBL
  ENSCAFT00030016185.1 UniProtKB/TrEMBL
  ENSCAFT00030020115.1 UniProtKB/TrEMBL
  ENSCAFT00040004007.1 UniProtKB/TrEMBL
  ENSCAFT00845007599 ENTREZGENE
  ENSCAFT00845007599.1 UniProtKB/TrEMBL
  ENSCAFT00845027579.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/TrEMBL
  3.10.20.30 UniProtKB/TrEMBL
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/TrEMBL
  2Fe2S_fd_BS UniProtKB/TrEMBL
  4Fe4S_Fe-S-bd UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/TrEMBL
  Succ_DH/fum_Rdtase_Fe-S UniProtKB/TrEMBL
  Succ_DH/fum_Rdtase_N UniProtKB/TrEMBL
KEGG Report cfa:478217 UniProtKB/TrEMBL
NCBI Gene SDHB ENTREZGENE
PANTHER SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN UniProtKB/TrEMBL
Pfam Fer2_3 UniProtKB/TrEMBL
  Fer4_17 UniProtKB/TrEMBL
PROSITE 2FE2S_FER_1 UniProtKB/TrEMBL
  2FE2S_FER_2 UniProtKB/TrEMBL
  4FE4S_FER_1 UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/TrEMBL
Superfamily-SCOP alpha-helical ferredoxin UniProtKB/TrEMBL
  SSF54292 UniProtKB/TrEMBL
UniProt A0A8C0N0V5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RFS0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MX02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S1H7 ENTREZGENE, UniProtKB/TrEMBL
  Q0QEY4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45951 ENTREZGENE