ALKAL2 (ALK and LTK ligand 2) - Rat Genome Database

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Gene: ALKAL2 (ALK and LTK ligand 2) Canis lupus familiaris
Analyze
Symbol: ALKAL2
Name: ALK and LTK ligand 2
RGD ID: 12054824
Description: ENCODES a protein that exhibits transmembrane receptor protein tyrosine kinase activator activity (ortholog); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); positive regulation of neuron projection development (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102155602; uncharacterized LOC102155602
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.117269,433 - 274,035 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha17245,925 - 251,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.017313,875 - 319,415 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.117240,877 - 246,411 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.017259,114 - 264,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.017263,761 - 269,297 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ALKAL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.117269,433 - 274,035 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha17245,925 - 251,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.017313,875 - 319,415 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.117240,877 - 246,411 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.017259,114 - 264,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.017263,761 - 269,297 (-)NCBIUU_Cfam_GSD_1.0
ALKAL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382279,558 - 288,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2279,558 - 288,851 (-)EnsemblGRCh38hg38GRCh38
GRCh372279,558 - 288,091 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362269,561 - 278,308 (-)NCBINCBI36Build 36hg18NCBI36
Celera2342,204 - 350,952 (-)NCBICelera
Cytogenetic Map2p25.3NCBI
HuRef2276,125 - 285,012 (-)NCBIHuRef
CHM1_12279,498 - 288,245 (-)NCBICHM1_1
T2T-CHM13v2.02279,817 - 288,348 (-)NCBIT2T-CHM13v2.0
Alkal2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391230,934,323 - 30,943,855 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1230,934,321 - 30,943,853 (+)EnsemblGRCm39 Ensembl
GRCm381230,884,324 - 30,893,856 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1230,884,322 - 30,893,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv371231,569,189 - 31,578,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1232,337,032 - 32,346,676 (+)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.0NCBI
Alkal2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8653,223,204 - 53,232,794 (+)NCBIGRCr8
mRatBN7.2647,495,645 - 47,505,235 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl647,495,782 - 47,505,234 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx647,801,799 - 47,811,177 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0648,116,707 - 48,126,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0647,561,775 - 47,571,161 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0649,824,725 - 49,834,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,825,469 - 49,834,912 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0658,505,183 - 58,514,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4648,772,245 - 48,781,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera646,700,921 - 46,710,297 (+)NCBICelera
Cytogenetic Map6q16NCBI
Alkal2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487307,055 - 311,990 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487304,019 - 312,577 (-)NCBIChiLan1.0ChiLan1.0
ALKAL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212126,259,289 - 126,268,416 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A126,263,265 - 126,272,392 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A272,597 - 281,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A268,376 - 276,180 (-)NCBIpanpan1.1PanPan1.1panPan2
Alkal2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629245,391,553 - 45,399,438 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936532150,068 - 154,481 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936532146,648 - 154,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALKAL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3132,660,909 - 132,670,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13132,661,153 - 132,671,270 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23142,398,451 - 142,405,870 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALKAL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114107,438,932 - 107,448,066 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14107,439,646 - 107,444,580 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660454,492,111 - 4,502,956 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alkal2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248461,749,498 - 1,756,155 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248461,749,498 - 1,756,622 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALKAL2
82 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_038453155   ⟹   XP_038309083
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha17245,925 - 251,463 (-)NCBI
RefSeq Acc Id: XM_038499840   ⟹   XP_038355768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.117240,877 - 246,411 (-)NCBI
RefSeq Acc Id: XM_038560642   ⟹   XP_038416570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.017263,761 - 269,297 (-)NCBI
RefSeq Acc Id: XM_038624668   ⟹   XP_038480596
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.017259,114 - 264,635 (-)NCBI
RefSeq Acc Id: XM_038690518   ⟹   XP_038546446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.017313,875 - 319,415 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038355768   ⟸   XM_038499840
RefSeq Acc Id: XP_038480596   ⟸   XM_038624668
RefSeq Acc Id: XP_038546446   ⟸   XM_038690518
- UniProtKB: A0A8P0PG31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038309083   ⟸   XM_038453155
- UniProtKB: A0A8P0PG31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038416570   ⟸   XM_038560642
- UniProtKB: A0A8P0PG31 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000054804 UniProtKB/TrEMBL
  ENSCAFG00845017008 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000109647.1 UniProtKB/TrEMBL
  ENSCAFT00845030121.1 UniProtKB/TrEMBL
InterPro FAM150A/B UniProtKB/TrEMBL
NCBI Gene LOC102155602 ENTREZGENE
PANTHER ALK AND LTK LIGAND 2 UniProtKB/TrEMBL
  PTHR28676 UniProtKB/TrEMBL
Pfam FAM150 UniProtKB/TrEMBL
UniProt A0A8I3NYE8_CANLF UniProtKB/TrEMBL
  A0A8P0PG31 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 ALKAL2  ALK and LTK ligand 2  LOC102155602  uncharacterized LOC102155602  Symbol and/or name change 5135510 APPROVED