SMAD7 (SMAD family member 7) - Rat Genome Database

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Gene: SMAD7 (SMAD family member 7) Canis lupus familiaris
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Symbol: SMAD7
Name: SMAD family member 7
RGD ID: 12053869
Description: ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); intracellular signal transduction (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; ASSOCIATED WITH atrial fibrillation (ortholog); colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mothers against decapentaplegic homolog 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1779,706,485 - 79,734,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0779,520,644 - 79,548,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,805,995 - 79,834,706 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction assembly  (IEA)
anatomical structure morphogenesis  (IEA)
artery morphogenesis  (IEA)
cell differentiation  (IEA)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
intracellular signal transduction  (ISO)
negative regulation of activin receptor signaling pathway  (IEA)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of chondrocyte proliferation  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ossification  (IEA)
negative regulation of peptidyl-serine phosphorylation  (IEA)
negative regulation of peptidyl-threonine phosphorylation  (IEA)
negative regulation of protein ubiquitination  (IEA)
negative regulation of SMAD protein signal transduction  (IEA)
negative regulation of T cell cytokine production  (IEA)
negative regulation of T-helper 17 cell differentiation  (IEA)
negative regulation of T-helper 17 type immune response  (IEA)
negative regulation of transcription by competitive promoter binding  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of cell-cell adhesion  (IEA)
positive regulation of chondrocyte hypertrophy  (IEA)
protein stabilization  (IEA)
protein-containing complex localization  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial to mesenchymal transition  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
response to laminar fluid shear stress  (IEA)
SMAD protein signal transduction  (IEA)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
ureteric bud development  (IEA)
ventricular cardiac muscle tissue morphogenesis  (IEA)
ventricular septum morphogenesis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:34689106  


Genomics

Comparative Map Data
SMAD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1779,706,485 - 79,734,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0779,520,644 - 79,548,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,805,995 - 79,834,706 (+)NCBIUU_Cfam_GSD_1.0
SMAD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381848,919,853 - 48,950,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1848,919,853 - 48,950,965 (-)EnsemblGRCh38hg38GRCh38
GRCh371846,446,223 - 46,477,335 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361844,700,221 - 44,731,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 341844,700,221 - 44,731,079NCBI
Celera1843,299,268 - 43,330,141 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1843,299,249 - 43,329,936 (-)NCBIHuRef
CHM1_11846,441,162 - 46,472,026 (-)NCBICHM1_1
T2T-CHM13v2.01849,115,112 - 49,146,228 (-)NCBIT2T-CHM13v2.0
Smad7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391875,500,436 - 75,529,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1875,500,600 - 75,529,006 (+)EnsemblGRCm39 Ensembl
GRCm381875,367,365 - 75,395,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1875,367,529 - 75,395,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371875,527,019 - 75,555,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361875,492,894 - 75,521,292 (+)NCBIMGSCv36mm8
Celera1876,602,062 - 76,630,688 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.06NCBI
Smad7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81871,263,508 - 71,291,849 (+)NCBIGRCr8
mRatBN7.21868,988,429 - 69,016,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,988,429 - 69,016,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,094,956 - 71,123,284 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01871,764,762 - 71,793,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01869,620,987 - 69,649,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01871,395,830 - 71,424,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,530,559 - 70,558,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41872,294,803 - 72,323,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11872,368,075 - 72,396,625 (+)NCBI
Celera1867,155,575 - 67,183,461 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
Smad7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540234,028,063 - 34,058,291 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,028,184 - 34,058,949 (-)NCBIChiLan1.0ChiLan1.0
SMAD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21766,454,709 - 66,485,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11852,147,312 - 52,178,129 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01842,306,324 - 42,337,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11845,659,375 - 45,689,505 (-)NCBIpanpan1.1PanPan1.1panPan2
Smad7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494438,655,545 - 38,682,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649713,894,580 - 13,922,065 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649713,894,586 - 13,921,978 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl198,514,267 - 98,542,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1198,512,800 - 98,543,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,087,677 - 108,118,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11831,993,543 - 32,024,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1831,993,681 - 32,024,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660506,227,954 - 6,258,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477812,415,282 - 12,444,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477812,415,364 - 12,444,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SMAD7
452 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 4 12 10 6
Low 2 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000030280   ⟹   ENSCAFP00000028133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000091073   ⟹   ENSCAFP00000058215
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845030191   ⟹   ENSCAFP00845023674
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845030212   ⟹   ENSCAFP00845023690
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)Ensembl
RefSeq Acc Id: XM_005623131   ⟹   XP_005623188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1779,706,485 - 79,734,673 (+)NCBI
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038482526   ⟹   XP_038338454
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBI
RefSeq Acc Id: XM_038482527   ⟹   XP_038338455
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBI
RefSeq Acc Id: XM_038543992   ⟹   XP_038399920
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0779,805,995 - 79,834,706 (+)NCBI
RefSeq Acc Id: XM_038608093   ⟹   XP_038464021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0779,520,644 - 79,548,552 (+)NCBI
RefSeq Acc Id: XM_038672800   ⟹   XP_038528728
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBI
RefSeq Acc Id: XM_038672801   ⟹   XP_038528729
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBI
RefSeq Acc Id: XM_845400   ⟹   XP_850493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1779,706,485 - 79,734,673 (+)NCBI
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBI
Sequence:
RefSeq Acc Id: XP_850493   ⟸   XM_845400
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LW86 (UniProtKB/TrEMBL),   A0A8C0LRR7 (UniProtKB/TrEMBL),   A0A8I3P368 (UniProtKB/TrEMBL),   A0A8C0SNL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005623188   ⟸   XM_005623131
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SNL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000028133   ⟸   ENSCAFT00000030280
RefSeq Acc Id: ENSCAFP00000058215   ⟸   ENSCAFT00000091073
RefSeq Acc Id: XP_038338454   ⟸   XM_038482526
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038338455   ⟸   XM_038482527
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038464021   ⟸   XM_038608093
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038528728   ⟸   XM_038672800
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LW86 (UniProtKB/TrEMBL),   A0A8C0LRR7 (UniProtKB/TrEMBL),   A0A8I3P368 (UniProtKB/TrEMBL),   A0A8C0SNL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528729   ⟸   XM_038672801
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SNL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399920   ⟸   XM_038543992
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SNL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845023674   ⟸   ENSCAFT00845030191
RefSeq Acc Id: ENSCAFP00845023690   ⟸   ENSCAFT00845030212
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019069 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001639 UniProtKB/TrEMBL
  ENSCAFG00040014862 UniProtKB/TrEMBL
  ENSCAFG00845017036 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030280.6 UniProtKB/TrEMBL
  ENSCAFT00000091073.2 UniProtKB/TrEMBL
  ENSCAFT00030002966.1 UniProtKB/TrEMBL
  ENSCAFT00030002994.1 UniProtKB/TrEMBL
  ENSCAFT00040027530.1 UniProtKB/TrEMBL
  ENSCAFT00040027567.1 UniProtKB/TrEMBL
  ENSCAFT00040027612.1 UniProtKB/TrEMBL
  ENSCAFT00040027678.1 UniProtKB/TrEMBL
  ENSCAFT00845030191.1 UniProtKB/TrEMBL
  ENSCAFT00845030212 ENTREZGENE
  ENSCAFT00845030212.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene SMAD7 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt A0A8C0LRR7 ENTREZGENE
  A0A8C0LW86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0M691_CANLF UniProtKB/TrEMBL
  A0A8C0SMS1_CANLF UniProtKB/TrEMBL
  A0A8C0SNL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NYK2_CANLF UniProtKB/TrEMBL
  A0A8I3P368 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46524 ENTREZGENE