DBT (dihydrolipoamide branched chain transacylase E2)

Gene: DBT (dihydrolipoamide branched chain transacylase E2) Canis lupus familiaris

Analyze

Symbol:

DBT

Name:

dihydrolipoamide branched chain transacylase E2

RGD ID:

12052841

Description:

ENCODES a protein that exhibits branched-chain alpha-keto acid dehydrogenase activity (ortholog); INVOLVED IN branched-chain amino acid catabolic process (inferred); carboxylic acid metabolic process (inferred); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); maple syrup urine disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); microtubule cytoskeleton (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	49,753,233 - 49,805,493 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	49,753,323 - 49,805,882 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	52,424,469 - 52,476,285 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	50,100,981 - 50,152,844 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	50,101,072 - 50,153,426 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	49,792,722 - 49,844,579 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	49,771,509 - 49,823,578 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	50,201,398 - 50,255,118 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

genetic disease (ISO)

maple syrup urine disease (ISO)

Maple Syrup Urine Disease, Type 1A (ISO)

Maple Syrup Urine Disease, Type 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branched-chain amino acid catabolic process (IEA)

carboxylic acid metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

microtubule cytoskeleton (IEA)

mitochondrial matrix (IEA)

mitochondrial nucleoid (IEA)

mitochondrion (IEA)

Molecular Function

acetyltransferase activity (IEA)

acyltransferase activity (IEA)

branched-chain alpha-keto acid dehydrogenase activity (IEA,ISO)

lipoic acid binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

malonic aciduria pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

methylmalonic aciduria, cobalamin-related pathway (ISO)

propanoate metabolic pathway (ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

DBT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	49,753,233 - 49,805,493 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	49,753,323 - 49,805,882 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	52,424,469 - 52,476,285 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	50,100,981 - 50,152,844 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	50,101,072 - 50,153,426 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	49,792,722 - 49,844,579 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	49,771,509 - 49,823,578 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	50,201,398 - 50,255,118 (+)	NCBI		UU_Cfam_GSD_1.0

DBT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	100,186,919 - 100,249,834 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	100,186,919 - 100,249,834 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	100,652,475 - 100,715,390 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	100,425,066 - 100,487,997 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	100,371,756 - 100,427,411	NCBI
Celera	1	98,909,336 - 98,972,208 (-)	NCBI		Celera
Cytogenetic Map	1	p21.2	NCBI
HuRef	1	98,775,207 - 98,838,837 (-)	NCBI		HuRef
CHM1_1	1	100,768,800 - 100,831,605 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	100,035,014 - 100,097,802 (-)	NCBI		T2T-CHM13v2.0

Dbt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	116,306,776 - 116,343,630 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	116,306,719 - 116,343,630 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	116,513,070 - 116,549,981 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	116,513,070 - 116,549,981 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	116,215,997 - 116,252,899 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	116,505,145 - 116,541,403 (+)	NCBI		MGSCv36	mm8
Celera	3	122,940,011 - 122,977,028 (+)	NCBI		Celera
Cytogenetic Map	3	G1	NCBI
cM Map	3	50.37	NCBI

Dbt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	207,166,660 - 207,195,528 (+)	NCBI		GRCr8
mRatBN7.2	2	204,481,744 - 204,510,612 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	204,481,737 - 204,510,609 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	212,138,239 - 212,167,245 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	210,047,347 - 210,076,203 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	204,864,426 - 204,893,276 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	219,563,783 - 219,592,651 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	219,563,783 - 219,592,650 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	237,625,211 - 237,654,081 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	212,759,312 - 212,788,180 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	212,731,165 - 212,742,429 (+)	NCBI
Celera	2	196,974,438 - 197,002,611 (+)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

Dbt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	4,973,830 - 5,017,816 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	4,975,664 - 5,005,126 (-)	NCBI	ChiLan1.0	ChiLan1.0

DBT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	126,778,646 - 126,854,613 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	125,936,695 - 126,011,918 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	102,852,585 - 102,907,146 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	101,566,152 - 101,621,850 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	101,567,551 - 101,621,850 (-)	Ensembl	panpan1.1		panPan2

Dbt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	110,537,454 - 110,580,910 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936748	342,394 - 386,000 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936748	342,655 - 386,017 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DBT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	117,875,002 - 117,936,612 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	117,884,657 - 117,924,006 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	129,512,220 - 129,548,961 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DBT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	33,088,452 - 33,157,693 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	33,088,496 - 33,140,403 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	24,899,712 - 24,968,926 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dbt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624857	3,056,781 - 3,138,396 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624857	3,056,799 - 3,138,430 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in DBT
547 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium			5				4				3	4
Low	5	5	17	6	6	6	2	6	12	8	7	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038479934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038541212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038605363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038670000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_537055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000031852 ⟹ ENSCAFP00000029657

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	49,753,323 - 49,804,750 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000059934 ⟹ ENSCAFP00000044167

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	6	49,753,323 - 49,805,882 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845023548 ⟹ ENSCAFP00845018488

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	6	50,101,072 - 50,153,426 (+)	Ensembl

RefSeq Acc Id:

XM_038479934 ⟹ XP_038335862

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	6	49,792,722 - 49,844,579 (+)	NCBI

RefSeq Acc Id:

XM_038541212 ⟹ XP_038397140

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	6	50,201,398 - 50,255,118 (+)	NCBI

RefSeq Acc Id:

XM_038605363 ⟹ XP_038461291

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	6	49,771,509 - 49,823,578 (+)	NCBI

RefSeq Acc Id:

XM_038670000 ⟹ XP_038525928

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	6	50,100,981 - 50,152,844 (+)	NCBI

RefSeq Acc Id:

XM_537055 ⟹ XP_537055

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	49,753,233 - 49,805,493 (+)	NCBI
Dog10K_Boxer_Tasha	6	52,424,469 - 52,476,285 (+)	NCBI

Sequence:

show sequence

GGAGGCTCGTTCCTGTCCTCGCCATTGGCCGCTCGGGGGGCGGCGCGTTCCCCGGCTCCCGGTT
GGTGGTCCGCGCGCTTGTCATTTCCGGGTAAGATGGCTGCAGTGCGTGTGCTCGGGACGTGGAG
CCGGAATGCTGGGCGGCTGATTTGTGTTCGCTACTTTCAAACATGTAATAATGTTCATATTTTG
AAGCCAAAGTATGTGTGTTTCTTTGGTTATCCTTCATTCAAATATAGTCATCCACATCAGTTGC
TGCAAACAAGTGCTGCTCTGCAGGGACAGATTGTTCAATTCAAACTATCAGACATCGGAGAAGG
GATTAGAGAAGTAACTATTAAAGAATGGTATGTAAAAGAAGGAGATACAGTGTCTCAGTTTGAT
AGCATCTGTGAAGTTCAAAGTGATAAAGCTTCTGTTACTATCACTAGTCGTTATGATGGAGTCA
TTAAAAAACTGTATTATAATCTAGACGATATTGCCTATGTGGGAAAGCCATTAGTAGACATAGA
AACGGAAGCTTTAAAAGATTCAGAAGAAGATGTTGTTGAAACTCCTGCTGTGTCCCATGATGAA
CACACACACCAAGAGATAAAGGGCCAGAAAACACTGGCAACTCCTGCAGTTCGCCGCCTAGCAA
TGGAAAACAATATTAAGCTGAGTGAAGTTGTCGGCTCAGGAAAAGACGGCCGAATACTCAAAGA
AGACATCCTCAACTATTTGGAAAAGCAGACTGGAGCTATATTACCTCCTTCGCCCAAAGCTGAA
CTAGTGCCACCTCCACCAACACCGAAAGGCAAAGTTACTCCTATGCCAGCATCAAAACCTCCAG
CATTCACAGGCAGAGACAGAACGGAGCCCATAAAAGGCTTTCACAAAGCAATGGTCAAGACCAT
GTCTGCAGCTCTGAAGATACCTCATTTTGGATATTGTGATGAGGTTGACCTTACTGAATTGGTT
AAGTTAAGAGAAGAATTAAAACCCATTGCTTTTGCTCGTGGAATTAAACTCTCCTTTATGCCCT
TCTTCTTAAAGGCTGCATCCTTGGGACTGCTACAGTTTCCCATCCTTAATGCTTCTGTGGATGA
AAACTGCCAGCACATAACTTATAAGGCTTCTCACAACATTGGGGTAGCAATGGATACTGAGCAG
GGGCTAATTGTCCCTAATGTGAAAAATGTTCAGATCTGCTCCATATTTGAGATCGCCACTGAGT
TGAACCGCCTTCAGAAATTGGGCTCTATAGGCCAGCTCAGTACCACTGATCTGGCCGGAGGAAC
ATTTACTCTTTCCAACATTGGATCAATTGGTGGTACCTATACCAAACCAGTGATACTGCCACCT
GAAGTAGCAATTGGGGCTCTCGGATCAATTAAGGCCCTTCCCCGATTTAACCACAAAGGAGAAG
TATATAAAGCACAGATAATGAATGTGAGCTGGTCAGCTGATCACAGAATTATTGATGGTGCTAC
AATGTCACGCTTCTCTAATTTGTGGAAATCCTACTTAGAAAACCCAGCTTTTATGCTACTAGAT
CTGAAATGAAGATTGATGGGACGTCAATGAACTTTCTGATCTTCCAAAGAATATGTAGCGCCTA
ACTGTGCAGCACATGTTCTTCATCACAATTTGTATTATAAATGATTTGTATTGTATGATTAAGG
TTCCAAGGCACAATATTTACACTGTTCTGTTAGACTTTTTACTGAAAGTGAATAATGATGTAAG
AGTTCTCCTAGGGCTGTCACATTGTATAGGTCATGGTGTGACTTCTTAATATGGTGCTGAGGTC
TTTGTGTCCATGAATTGAAAACTAGCAAGAAAAACAAAATTAATGTTACTAAAAGACAGACTGC
CATATCCAGTGTGGATATCTATTTTTTTCCTTTCATTTTTTATTTTAGACTGACCTTAATGAAA
CATGTCAGTTACACTTAGTTGGGAAAAGGAATTTACATACAGAAGTATCTTCCATTTCCCCACA
ATAACGCTAACTATTGTATAAAATAAGTGCAATTACTTAACCTTTTAAGATACCCACGATTATG
TTGCTCTGTAGAAATTAACTGTAAATGTCTTGTTTATATGAATTAATATCTTTTAAAAGGGAAA
ATTATAAGCTGATCTTAAAAATGCCCAATTATAGGGATGCGTGGCTGGCCCAGTCTGAAGAGCA
TGTGACTCTTGATCTCAGGGTCATGAGTTCAAGCCCCATATTGGGTATAGAGCCTACTTAAAAA
AAAAGGTAGGGGGGATGCCTGGGTGGCTCAGCGGTTTGGGCATCTGCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_038335862	(Get FASTA)	NCBI Sequence Viewer
	XP_038397140	(Get FASTA)	NCBI Sequence Viewer
	XP_038461291	(Get FASTA)	NCBI Sequence Viewer
	XP_038525928	(Get FASTA)	NCBI Sequence Viewer
	XP_537055	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000029657.3
	ENSCAFP00000044167.2
	ENSCAFP00030027654.1
	ENSCAFP00040003395.1
	ENSCAFP00040003412.1
	ENSCAFP00845018488
	ENSCAFP00845018488.1

RefSeq Acc Id:

XP_537055 ⟸ XM_537055

- UniProtKB:

A0A8C0NJC4 (UniProtKB/TrEMBL), A0A8I3NPD0 (UniProtKB/TrEMBL), A0A8C0KBT9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVRVLGTWSRNAGRLICVRYFQTCNNVHILKPKYVCFFGYPSFKYSHPHQLLQTSAALQGQI
VQFKLSDIGEGIREVTIKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDI
AYVGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGQKTLATPAVRRLAMENNIKLSEVV
GSGKDGRILKEDILNYLEKQTGAILPPSPKAELVPPPPTPKGKVTPMPASKPPAFTGRDRTEPI
KGFHKAMVKTMSAALKIPHFGYCDEVDLTELVKLREELKPIAFARGIKLSFMPFFLKAASLGLL
QFPILNASVDENCQHITYKASHNIGVAMDTEQGLIVPNVKNVQICSIFEIATELNRLQKLGSIG
QLSTTDLAGGTFTLSNIGSIGGTYTKPVILPPEVAIGALGSIKALPRFNHKGEVYKAQIMNVSW
SADHRIIDGATMSRFSNLWKSYLENPAFMLLDLK

hide sequence

RefSeq Acc Id:

ENSCAFP00000044167 ⟸ ENSCAFT00000059934

RefSeq Acc Id:

ENSCAFP00000029657 ⟸ ENSCAFT00000031852

RefSeq Acc Id:

XP_038335862 ⟸ XM_038479934

RefSeq Acc Id:

XP_038461291 ⟸ XM_038605363

RefSeq Acc Id:	XP_038525928 ⟸ XM_038670000
- UniProtKB:	A0A8C0NJC4 (UniProtKB/TrEMBL), A0A8I3NPD0 (UniProtKB/TrEMBL), A0A8C0KBT9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038397140 ⟸ XM_038541212
- UniProtKB:	A0A8C0KBT9 (UniProtKB/TrEMBL), A0A8C0NJC4 (UniProtKB/TrEMBL), A0A8I3NPD0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845018488 ⟸ ENSCAFT00845023548

Protein Domains

Lipoyl-binding Peripheral subunit-binding (PSBD)

Promoters

RGD ID:

13683807

Promoter ID:

EPDNEW_C1873

Type:

multiple initiation site

Name:

DBT_1

Description:

dihydrolipoamide branched chain transacylase E2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	6	49,753,316 - 49,753,376	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020011	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030017186	UniProtKB/TrEMBL
	ENSCAFG00040002089	UniProtKB/TrEMBL
	ENSCAFG00845013225	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000031852.5	UniProtKB/TrEMBL
	ENSCAFT00000059934.2	UniProtKB/TrEMBL
	ENSCAFT00030031708.1	UniProtKB/TrEMBL
	ENSCAFT00040003954.1	UniProtKB/TrEMBL
	ENSCAFT00040003976.1	UniProtKB/TrEMBL
	ENSCAFT00845023548	ENTREZGENE
	ENSCAFT00845023548.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.100	UniProtKB/TrEMBL
	3.30.559.10	UniProtKB/TrEMBL
	4.10.320.10	UniProtKB/TrEMBL
InterPro	2-oxoA_DH_lipoyl-BS	UniProtKB/TrEMBL
	2-oxoacid_DH_actylTfrase	UniProtKB/TrEMBL
	Biotin_lipoyl	UniProtKB/TrEMBL
	CAT-like_dom_sf	UniProtKB/TrEMBL
	E3-bd_dom_sf	UniProtKB/TrEMBL
	PSBD	UniProtKB/TrEMBL
	Single_hybrid_motif	UniProtKB/TrEMBL
KEGG Report	cfa:479929	UniProtKB/TrEMBL
NCBI Gene	DBT	ENTREZGENE
PANTHER	DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX	UniProtKB/TrEMBL
	LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	2-oxoacid_dh	UniProtKB/TrEMBL
	Biotin_lipoyl	UniProtKB/TrEMBL
	E3_binding	UniProtKB/TrEMBL
PROSITE	BIOTINYL_LIPOYL	UniProtKB/TrEMBL
	LIPOYL	UniProtKB/TrEMBL
	PSBD	UniProtKB/TrEMBL
Superfamily-SCOP	CoA-dependent acyltransferases	UniProtKB/TrEMBL
	SSF47005	UniProtKB/TrEMBL
	SSF51230	UniProtKB/TrEMBL
UniProt	A0A8C0KBT9	ENTREZGENE
	A0A8C0NJC4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RW14_CANLF	UniProtKB/TrEMBL
	A0A8I3NPD0	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A8P0SXF0	UniProtKB/TrEMBL
VGNC ID	VGNC:39787	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB