DBT (dihydrolipoamide branched chain transacylase E2) - Rat Genome Database

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Gene: DBT (dihydrolipoamide branched chain transacylase E2) Canis lupus familiaris
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Symbol: DBT
Name: dihydrolipoamide branched chain transacylase E2
RGD ID: 12052841
Description: ENCODES a protein that exhibits ubiquitin protein ligase binding (inferred); INVOLVED IN branched-chain amino acid catabolic process (inferred); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); maple syrup urine disease (ortholog); Maple Syrup Urine Disease, Type 2 (ortholog); FOUND IN mitochondrial alpha-ketoglutarate dehydrogenase complex (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1649,753,233 - 49,805,493 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl649,753,323 - 49,805,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,424,469 - 52,476,285 (+)NCBI
ROS_Cfam_1.0650,100,981 - 50,152,844 (+)NCBI
UMICH_Zoey_3.1649,792,722 - 49,844,579 (+)NCBI
UNSW_CanFamBas_1.0649,771,509 - 49,823,578 (+)NCBI
UU_Cfam_GSD_1.0650,201,398 - 50,255,118 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
DBT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1649,753,233 - 49,805,493 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl649,753,323 - 49,805,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,424,469 - 52,476,285 (+)NCBI
ROS_Cfam_1.0650,100,981 - 50,152,844 (+)NCBI
UMICH_Zoey_3.1649,792,722 - 49,844,579 (+)NCBI
UNSW_CanFamBas_1.0649,771,509 - 49,823,578 (+)NCBI
UU_Cfam_GSD_1.0650,201,398 - 50,255,118 (+)NCBI
DBT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1100,186,919 - 100,249,834 (-)EnsemblGRCh38hg38GRCh38
GRCh381100,186,919 - 100,249,864 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371100,652,475 - 100,715,390 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361100,425,066 - 100,487,997 (-)NCBINCBI36hg18NCBI36
Build 341100,371,756 - 100,427,411NCBI
Celera198,909,336 - 98,972,208 (-)NCBI
Cytogenetic Map1p21.2NCBI
HuRef198,775,207 - 98,838,837 (-)NCBIHuRef
CHM1_11100,768,800 - 100,831,605 (-)NCBICHM1_1
Dbt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393116,306,719 - 116,343,630 (+)NCBIGRCm39mm39
GRCm39 Ensembl3116,306,719 - 116,343,630 (+)Ensembl
GRCm383116,513,070 - 116,549,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3116,513,070 - 116,549,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv373116,215,997 - 116,252,899 (+)NCBIGRCm37mm9NCBIm37
MGSCv363116,505,145 - 116,541,403 (+)NCBImm8
Celera3122,940,011 - 122,977,028 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.37NCBI
Dbt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22204,481,744 - 204,510,612 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2204,481,737 - 204,510,609 (+)Ensembl
Rnor_6.02219,563,783 - 219,592,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,563,783 - 219,592,650 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,625,211 - 237,654,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,759,312 - 212,788,180 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12212,731,165 - 212,742,429 (+)NCBI
Celera2196,974,438 - 197,002,611 (+)NCBICelera
Cytogenetic Map2q41NCBI
Dbt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554354,973,830 - 5,017,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554354,975,664 - 5,005,126 (-)NCBIChiLan1.0ChiLan1.0
DBT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11101,566,152 - 101,621,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1101,567,551 - 101,621,850 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01102,852,585 - 102,907,146 (-)NCBIMhudiblu_PPA_v0panPan3
Dbt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058110,537,454 - 110,580,910 (-)NCBI
SpeTri2.0NW_004936748342,655 - 386,017 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4117,875,002 - 117,937,561 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14117,884,657 - 117,924,006 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24129,512,220 - 129,548,961 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DBT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12033,088,452 - 33,157,693 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2033,088,496 - 33,140,403 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603824,899,712 - 24,968,926 (-)NCBIVero_WHO_p1.0
Dbt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248573,056,799 - 3,138,430 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 3 4
Low 5 5 17 6 6 6 2 6 12 8 7 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000031852   ⟹   ENSCAFP00000029657
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl649,753,323 - 49,804,750 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000059934   ⟹   ENSCAFP00000044167
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl649,753,323 - 49,805,882 (+)Ensembl
RefSeq Acc Id: XM_038479934   ⟹   XP_038335862
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1649,792,722 - 49,844,579 (+)NCBI
RefSeq Acc Id: XM_038541212   ⟹   XP_038397140
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0650,201,398 - 50,255,118 (+)NCBI
RefSeq Acc Id: XM_038605363   ⟹   XP_038461291
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0649,771,509 - 49,823,578 (+)NCBI
RefSeq Acc Id: XM_038670000   ⟹   XP_038525928
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0650,100,981 - 50,152,844 (+)NCBI
RefSeq Acc Id: XM_537055   ⟹   XP_537055
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1649,753,233 - 49,805,493 (+)NCBI
Dog10K_Boxer_Tasha652,424,469 - 52,476,285 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038335862 (Get FASTA)   NCBI Sequence Viewer  
  XP_038397140 (Get FASTA)   NCBI Sequence Viewer  
  XP_038461291 (Get FASTA)   NCBI Sequence Viewer  
  XP_038525928 (Get FASTA)   NCBI Sequence Viewer  
  XP_537055 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_537055   ⟸   XM_537055
- UniProtKB: E2RQG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000044167   ⟸   ENSCAFT00000059934
RefSeq Acc Id: ENSCAFP00000029657   ⟸   ENSCAFT00000031852
RefSeq Acc Id: XP_038335862   ⟸   XM_038479934
RefSeq Acc Id: XP_038461291   ⟸   XM_038605363
RefSeq Acc Id: XP_038525928   ⟸   XM_038670000
RefSeq Acc Id: XP_038397140   ⟸   XM_038541212

Promoters
RGD ID:13683807
Promoter ID:EPDNEW_C1873
Type:multiple initiation site
Name:DBT_1
Description:dihydrolipoamide branched chain transacylase E2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1649,753,316 - 49,753,376EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
6 49799004 49799005 G T snv Kunming Dog (KM8)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020011 Ensembl
NCBI Gene DBT ENTREZGENE
UniProt E2RQG4 ENTREZGENE
VGNC ID VGNC:39787 ENTREZGENE