LOC100686073 (metallothionein-1) - Rat Genome Database

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Gene: LOC100686073 (metallothionein-1) Canis lupus familiaris
Analyze
Symbol: LOC100686073 (Ensembl: MT1E)
Name: metallothionein-1 (Ensembl:metallothionein 1E)
RGD ID: 12051364
Description: ENCODES a protein that exhibits copper ion binding (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to chromate (ortholog); cellular response to erythropoietin (ortholog); cellular response to zinc ion (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); lysosome (ortholog); INTERACTS WITH mercury dichloride
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,603,021 - 59,604,173 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,603,014 - 59,604,132 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,231,635 - 56,232,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,142,517 - 60,143,757 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,142,510 - 60,149,806 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,973,310 - 56,974,397 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,982,061 - 57,983,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,875,171 - 58,876,321 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISS)
cytosol  (ISO)
lysosome  (ISO)
nucleus  (IBA,IEA,ISS)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC100686073
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,603,021 - 59,604,173 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,603,014 - 59,604,132 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,231,635 - 56,232,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,142,517 - 60,143,757 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,142,510 - 60,149,806 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,973,310 - 56,974,397 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,982,061 - 57,983,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,875,171 - 58,876,321 (-)NCBIUU_Cfam_GSD_1.0
MT1X
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,682,470 - 56,684,196 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,682,470 - 56,684,196 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,716,382 - 56,718,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,273,896 - 55,275,609 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,273,895 - 55,275,608NCBI
Celera1641,213,751 - 41,215,476 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,585,539 - 42,587,264 (+)NCBIHuRef
CHM1_11658,123,317 - 58,125,042 (+)NCBICHM1_1
T2T-CHM13v2.01662,477,453 - 62,479,178 (+)NCBIT2T-CHM13v2.0
Mt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,905,214 - 94,906,955 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,905,710 - 94,906,955 (+)EnsemblGRCm39 Ensembl
GRCm38894,178,883 - 94,180,327 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,179,082 - 94,180,327 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,702,989 - 96,704,227 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,068,356 - 97,069,453 (+)NCBIMGSCv36mm8
Celera898,511,203 - 98,512,441 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.34NCBI
MT1X
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,155,127 - 66,157,088 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,074,025 - 72,075,974 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,959,854 - 36,961,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,092,205 - 56,093,976 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,092,218 - 56,093,976 (+)Ensemblpanpan1.1panPan2
LOC103233044
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,637,027 - 42,638,751 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,637,113 - 42,638,611 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,723,136 - 33,724,903 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in LOC100686073
38 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1 1 1
Medium 15 5 6 5 6 3 7 9 6
Low 5 5 6 3 5 8 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014488   ⟹   ENSCAFP00000013400
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl259,603,014 - 59,604,132 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006856   ⟹   ENSCAFP00845005461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,142,510 - 60,149,806 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006863   ⟹   ENSCAFP00845005465
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,142,524 - 60,149,806 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006877   ⟹   ENSCAFP00845005476
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,142,524 - 60,148,879 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006885   ⟹   ENSCAFP00845005483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,142,830 - 60,148,879 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006889   ⟹   ENSCAFP00845005486
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl260,147,232 - 60,149,806 (-)Ensembl
RefSeq Acc Id: XM_003433831   ⟹   XP_003433879
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1259,603,021 - 59,604,173 (-)NCBI
Dog10K_Boxer_Tasha256,231,635 - 56,232,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038470184   ⟹   XP_038326112
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1256,973,310 - 56,974,397 (-)NCBI
RefSeq Acc Id: XM_038531005   ⟹   XP_038386933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0258,875,171 - 58,876,321 (-)NCBI
RefSeq Acc Id: XM_038595225   ⟹   XP_038451153
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0257,982,061 - 57,983,213 (-)NCBI
RefSeq Acc Id: XM_038659310   ⟹   XP_038515238
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0260,142,517 - 60,143,757 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003433879   ⟸   XM_003433831
- UniProtKB: O19000 (UniProtKB/Swiss-Prot),   A0A8C0QVY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000013400   ⟸   ENSCAFT00000014488
RefSeq Acc Id: XP_038326112   ⟸   XM_038470184
RefSeq Acc Id: XP_038451153   ⟸   XM_038595225
RefSeq Acc Id: XP_038515238   ⟸   XM_038659310
- UniProtKB: O19000 (UniProtKB/Swiss-Prot),   A0A8C0QVY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386933   ⟸   XM_038531005
- UniProtKB: O19000 (UniProtKB/Swiss-Prot),   A0A8C0QVY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845005461   ⟸   ENSCAFT00845006856
RefSeq Acc Id: ENSCAFP00845005476   ⟸   ENSCAFT00845006877
RefSeq Acc Id: ENSCAFP00845005465   ⟸   ENSCAFT00845006863
RefSeq Acc Id: ENSCAFP00845005483   ⟸   ENSCAFT00845006885
RefSeq Acc Id: ENSCAFP00845005486   ⟸   ENSCAFT00845006889

Promoters
RGD ID:13682518
Promoter ID:EPDNEW_C585
Type:multiple initiation site
Name:MT1X_1
Description:Metallothionein-1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1259,604,137 - 59,604,197EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009110 UniProtKB/Swiss-Prot
  ENSCAFG00000009113 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030004152 UniProtKB/Swiss-Prot
  ENSCAFG00030004180 UniProtKB/Swiss-Prot
  ENSCAFG00040013737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040013776 UniProtKB/Swiss-Prot
  ENSCAFG00805002930 UniProtKB/Swiss-Prot
  ENSCAFG00805004762 UniProtKB/Swiss-Prot
  ENSCAFG00845003828 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014488.5 UniProtKB/Swiss-Prot
  ENSCAFT00000014491.5 UniProtKB/Swiss-Prot
  ENSCAFT00030007653.1 UniProtKB/Swiss-Prot
  ENSCAFT00030007700.1 UniProtKB/Swiss-Prot
  ENSCAFT00040025371.1 UniProtKB/Swiss-Prot
  ENSCAFT00040025388.1 UniProtKB/TrEMBL
  ENSCAFT00040025422.1 UniProtKB/Swiss-Prot
  ENSCAFT00805005384 UniProtKB/Swiss-Prot
  ENSCAFT00805008907 UniProtKB/Swiss-Prot
  ENSCAFT00805008913 UniProtKB/Swiss-Prot
  ENSCAFT00845006856.1 UniProtKB/TrEMBL
  ENSCAFT00845006863.1 UniProtKB/TrEMBL
  ENSCAFT00845006877 ENTREZGENE
  ENSCAFT00845006877.1 UniProtKB/Swiss-Prot
  ENSCAFT00845006885.1 UniProtKB/TrEMBL
  ENSCAFT00845006889.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:100686073 UniProtKB/Swiss-Prot
  cfa:403800 UniProtKB/Swiss-Prot
NCBI Gene LOC100686073 ENTREZGENE
PANTHER METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED UniProtKB/TrEMBL
  METALLOTHIONEIN-1X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METALLOTHIONEIN-3 UniProtKB/TrEMBL
  PTHR23299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0QVY2 ENTREZGENE
  A0A8C0SID1_CANLF UniProtKB/TrEMBL
  A0A8I3MJD9_CANLF UniProtKB/TrEMBL
  A0A8I3MU77_CANLF UniProtKB/TrEMBL
  MT1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE