CLDN8 (claudin 8) - Rat Genome Database

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Gene: CLDN8 (claudin 8) Canis lupus familiaris
Analyze
Symbol: CLDN8
Name: claudin 8
RGD ID: 12051082
Description: ENCODES a protein that exhibits structural molecule activity (inferred); INVOLVED IN bicellular tight junction assembly (inferred); cell adhesion (inferred); ASSOCIATED WITH genetic disease (ortholog); malignant mesothelioma (ortholog); FOUND IN apicolateral plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: claudin-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13125,088,451 - 25,090,719 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3125,067,825 - 25,090,388 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3125,081,031 - 25,083,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03125,202,944 - 25,205,222 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13125,152,567 - 25,154,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03125,162,068 - 25,164,343 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03125,626,351 - 25,628,630 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16322055   PMID:30032202  


Genomics

Comparative Map Data
CLDN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13125,088,451 - 25,090,719 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3125,067,825 - 25,090,388 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3125,081,031 - 25,083,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03125,202,944 - 25,205,222 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13125,152,567 - 25,154,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03125,162,068 - 25,164,343 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03125,626,351 - 25,628,630 (-)NCBIUU_Cfam_GSD_1.0
CLDN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,214,006 - 30,216,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,214,006 - 30,216,097 (-)EnsemblGRCh38hg38GRCh38
GRCh372131,586,324 - 31,588,415 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362130,508,201 - 30,510,189 (-)NCBINCBI36Build 36hg18NCBI36
Build 342130,508,200 - 30,510,189NCBI
Celera2116,769,465 - 16,771,610 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2116,995,205 - 16,997,350 (-)NCBIHuRef
CHM1_12131,147,901 - 31,150,046 (-)NCBICHM1_1
T2T-CHM13v2.02128,579,873 - 28,581,964 (-)NCBIT2T-CHM13v2.0
Cldn8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391688,357,714 - 88,360,071 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1688,357,716 - 88,360,071 (-)EnsemblGRCm39 Ensembl
GRCm381688,560,826 - 88,563,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1688,560,828 - 88,563,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv371688,561,071 - 88,563,428 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361688,449,685 - 88,451,994 (-)NCBIMGSCv36mm8
Celera1688,764,283 - 88,766,640 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.22NCBI
Cldn8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81141,362,081 - 41,364,330 (-)NCBIGRCr8
mRatBN7.21127,875,857 - 27,878,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,875,692 - 27,878,513 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1136,569,725 - 36,571,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01129,269,957 - 29,272,206 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01128,434,450 - 28,436,699 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01128,525,641 - 28,527,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1128,525,643 - 28,527,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01132,145,321 - 32,147,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,419,612 - 28,421,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11128,420,518 - 28,421,859 (-)NCBI
Celera1127,591,523 - 27,593,772 (-)NCBICelera
Cytogenetic Map11q11NCBI
Cldn8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540729,563,982 - 29,568,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540729,563,982 - 29,568,728 (-)NCBIChiLan1.0ChiLan1.0
CLDN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22226,385,128 - 26,387,221 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12121,240,806 - 21,242,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02116,634,733 - 16,636,809 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12130,019,035 - 30,021,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2130,020,274 - 30,020,951 (-)Ensemblpanpan1.1panPan2
Cldn8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497125,560,223 - 25,562,291 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650011,905,678 - 11,906,355 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650011,905,635 - 11,907,141 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13193,562,074 - 193,564,168 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113193,563,314 - 193,564,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213204,165,854 - 204,166,630 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,012,738 - 62,017,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl262,016,228 - 62,016,905 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660714,587,555 - 4,589,699 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474518,282,293 - 18,282,970 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474518,281,038 - 18,283,442 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CLDN8
37 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 11 6 6 8
Low 1 1 1 1 2
Below cutoff 5 10 5 6 5 6 6 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014017   ⟹   ENSCAFP00000012966
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3125,067,825 - 25,090,388 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000078852   ⟹   ENSCAFP00000059513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3125,067,825 - 25,090,388 (-)Ensembl
RefSeq Acc Id: XM_005638808   ⟹   XP_005638865
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13125,088,451 - 25,090,719 (-)NCBI
Dog10K_Boxer_Tasha3125,081,031 - 25,083,309 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038443319   ⟹   XP_038299247
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03125,202,944 - 25,205,222 (-)NCBI
RefSeq Acc Id: XM_038517737   ⟹   XP_038373665
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13125,152,567 - 25,154,844 (-)NCBI
RefSeq Acc Id: XM_038581314   ⟹   XP_038437242
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03125,626,351 - 25,628,630 (-)NCBI
RefSeq Acc Id: XM_038645694   ⟹   XP_038501622
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03125,162,068 - 25,164,343 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005638865   ⟸   XM_005638808
- UniProtKB: A0A8C0Z631 (UniProtKB/TrEMBL),   A0A8I3P7H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000059513   ⟸   ENSCAFT00000078852
RefSeq Acc Id: ENSCAFP00000012966   ⟸   ENSCAFT00000014017
RefSeq Acc Id: XP_038373665   ⟸   XM_038517737
RefSeq Acc Id: XP_038501622   ⟸   XM_038645694
RefSeq Acc Id: XP_038299247   ⟸   XM_038443319
- UniProtKB: A0A8C0Z631 (UniProtKB/TrEMBL),   A0A8I3P7H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437242   ⟸   XM_038581314
- UniProtKB: A0A8C0Z631 (UniProtKB/TrEMBL),   A0A8I3P7H8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008822 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040024168 UniProtKB/TrEMBL
  ENSCAFG00845021244 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014017.4 UniProtKB/TrEMBL
  ENSCAFT00000078852.2 UniProtKB/TrEMBL
  ENSCAFT00000096464.1 UniProtKB/TrEMBL
  ENSCAFT00040045047.1 UniProtKB/TrEMBL
  ENSCAFT00040045059.1 UniProtKB/TrEMBL
  ENSCAFT00845037523.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro Claudin UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
NCBI Gene CLDN8 ENTREZGENE
PANTHER PTHR12002 UniProtKB/TrEMBL
  PTHR12002:SF24 UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PRINTS CLAUDIN UniProtKB/TrEMBL
  CLAUDIN8 UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
UniProt A0A8C0Z629_CANLF UniProtKB/TrEMBL
  A0A8C0Z631 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P7H8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PMR2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53023 ENTREZGENE