GPR6 (G protein-coupled receptor 6)

Gene: GPR6 (G protein-coupled receptor 6) Pan paniscus

Analyze

Symbol:

GPR6

Name:

G protein-coupled receptor 6

RGD ID:

12049911

Description:

ENCODES a protein that exhibits sphingosine-1-phosphate receptor activity (ortholog); INVOLVED IN positive regulation of cytosolic calcium ion concentration (ortholog); sphingosine-1-phosphate receptor signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

G-protein coupled receptor 6

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	129,988,862 - 129,991,268 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	127,875,740 - 127,879,745 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	107,783,260 - 107,785,662 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	111,825,742 - 111,828,202 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of cytosolic calcium ion concentration (ISO)

sphingosine-1-phosphate receptor signaling pathway (ISO)

Molecular Function

sphingosine-1-phosphate receptor activity (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

GPR6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	129,988,862 - 129,991,268 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	127,875,740 - 127,879,745 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	107,783,260 - 107,785,662 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	111,825,742 - 111,828,202 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

GPR6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	109,978,311 - 109,980,720 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	109,978,256 - 109,980,720 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	110,299,514 - 110,301,923 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	110,406,991 - 110,408,616 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	110,406,989 - 110,408,615	NCBI
Celera	6	111,046,984 - 111,048,609 (+)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	107,866,913 - 107,868,538 (+)	NCBI		HuRef
CHM1_1	6	110,563,521 - 110,565,146 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	111,156,757 - 111,159,166 (+)	NCBI		T2T-CHM13v2.0

Gpr6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	40,945,973 - 40,948,286 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	40,945,973 - 40,948,281 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	41,069,977 - 41,072,290 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	41,069,977 - 41,072,285 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	40,790,299 - 40,791,390 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	40,758,908 - 40,759,999 (-)	NCBI		MGSCv36	mm8
Celera	10	41,965,591 - 41,966,682 (-)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI
cM Map	10	22.08	NCBI

Gpr6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	46,072,480 - 46,075,251 (-)	NCBI		GRCr8
mRatBN7.2	20	44,489,853 - 44,492,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	44,489,853 - 44,492,624 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	46,274,495 - 46,277,282 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,933,647 - 45,936,434 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	46,658,987 - 46,661,774 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	45,813,169 - 45,815,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,813,169 - 45,815,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	47,518,790 - 47,521,561 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	45,290,688 - 45,293,459 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

Gpr6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	34,781,598 - 34,783,926 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	34,781,598 - 34,783,926 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	66,721,466 - 66,723,153 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	66,720,606 - 66,723,157 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	66,541,151 - 66,542,732 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	67,606,543 - 67,608,124 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	12	66,954,314 - 66,955,894 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	66,803,410 - 66,804,991 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	67,075,134 - 67,076,715 (+)	NCBI		UU_Cfam_GSD_1.0

Gpr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	101,660,014 - 101,663,023 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936564	5,935,216 - 5,937,647 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936564	5,935,216 - 5,937,647 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	75,979,360 - 75,982,036 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	85,202,296 - 85,204,602 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	63,909,222 - 63,911,725 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	63,909,793 - 63,910,881 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	36,193,313 - 36,196,044 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624916	1,042,798 - 1,045,180 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624916	1,042,193 - 1,045,191 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003805505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003805505 ⟹ XP_003805553

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	129,988,862 - 129,991,268 (+)	NCBI
NHGRI_mPanPan1	6	127,875,740 - 127,879,745 (+)	NCBI
Mhudiblu_PPA_v0	6	107,783,260 - 107,785,662 (+)	NCBI
PanPan1.1	6	111,825,748 - 111,828,202 (+)	NCBI

Sequence:

show sequence

CAGCGCGCGCCGCTCGCAGCCGCCTTTTCTGCCACCAACTGTATCTCTCACTCGCGGCGCCGGC
ACAGCGACAGGCGCCCCGCGCTTGCCTCCTCCCCGGCCCGGCCGCCTCCTGCAGGCAGCTGCTC
TGTCCGCGCGGGGAGCTCAGCCCGGCGCCCCGCCTCGGCGCCCATGACCAGCGACTTCCAGAAG
TCCTGACGCCCCAGGGTGCAAATCCGGCCGCGATGAACGCGAGCGCCGCCTCGCTCAACGACTC
CCAGGTGGTGGTAGTGGCGGCCGAAGGAGCGGCGGCGGCGGCCACAGCAGCAGGGGGACCGGAC
ACAGGCGAATGGGGACCCCCTGCTGCGGCGGCTCTGGGAGCCGGCGGCGGAGCTAATGGGTCTC
TGGAGCTGTCCTCGCAGCTGTCGGCTGGGCCACCGGGACTCCTGCTGCCAGCGGTGAATCCGTG
GGACGTGCTCCTGTGCGTGTCGGGGACAGTGATCGCTGGAGAAAACGCGCTGGTGGTGGCGCTC
ATCGCGTCCACTCCGGCGCTGCGCACGCCCATGTTCGTGCTGGTGGGCAGCCTGGCCACCGCTG
ACCTATTGGCGGGCTGTGGCCTCATCTTGCACTTTGTGTTCCAGTACTTGGTGCCCTCGGAGAC
TGTGAGTCTGCTCACGGTGGGCTTCCTCGTGGCCTCCTTCGCCGCCTCTGTCAGTAGCCTGCTG
GCCATTACGGTGGACCGCTACCTGTCCCTGTATAACGCGCTCACCTATTACTCGCGCCGGACCC
TGTTGGGCGTGCACCTCCTGCTTGCCGCCACCTGGACCGTGTCCCTAGGCCTGGGGCTGCTGCC
CGTGCTGGGCTGGAACTGCCTGGCAGAGCGCGCCGCCTGCAGCGTGGTGCGCCCGCTGGCGCGC
AGCCACGTGGCTCTGCTCTCCGCCGCCTTCTTCATGGTCTTCGGCATCATGCTGCACCTGTACG
TGCGCATCTGCCAGGTGGTCTGGCGCCACGCGCACCAGATCGCTCTGCAGCAGCACTGCCTGGC
GCCACCCCACCTCGCTGCCACCAGAAAGGGTGTGGGTACACTGGCTGTGGTGCTGGGCACTTTC
GGCGCCAGCTGGCTGCCCTTCGCCATCTATTGCGTGGTGGGCAGCCATGAGGACCCGGCGGTCT
ACACTTACGCCACCCTGCTGCCCGCCACCTACAACTCCATGATCAATCCCATCATCTATGCCTT
CCGCAACCAGGAGATCCAGCGCGCCCTGTGGCTCCTGCTCTGTGGCTGTTTCCAGTCCAAAGTG
CCCTTTCGTTCCAGGTCTCCCAGCGAGGTCTGAAGGGCTCGCCCCGTGTTCTCTCACCAACACC
ACACCCCAACAAGCCAGCCTTTGGTAAGCTCGGTGCCTGCTGACGAACTCTGAGATCCCAATGG
TGTGAGTCTGACTTTGGAAAGAAAAAGGGACTAAAGAGAAATGCAACAAACTTACAAGGACAAA
GAGGCTTGTTGGCACTTTACATATACAGTGTATACATGTGTACATATATATACAAATATTTGTA
TCTTCTGGAGGTGTTCAGGATGTGGAGCTTCCTATTCTGTGAAAAACCCAGAAAAAGATATGGT
TGTATACTCAAATTGTACATCACATTTGTCAAACGAAGACATTCCAATACTGCTTAATTATAGC
ACTTTATTTTTAGCTGCTGAACTGCCAAAACAGTGTTGCCATTTTCAAGGGCAGGGAAAAGGGA
GTAAAAGGTGTATTTTTGTCGTATGTGATAGAATATTTTGCTGCACATGCATCAACAAATTACA
ACATATTTTGTACACGAATAAACCCATTACAAGAATGTAA

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Protein Sequences


Protein RefSeqs	XP_003805553	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_003805553 ⟸ XM_003805505

- Sequence:

show sequence

MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGP
PGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILH
FVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAAT
WTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHA
HQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATY
NSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV

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Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	GPR6	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar