IL12A (interleukin 12A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: IL12A (interleukin 12A) Pan paniscus
Analyze
Symbol: IL12A
Name: interleukin 12A
RGD ID: 12049404
Description: ENCODES a protein that exhibits cytokine activity (ortholog); growth factor activity (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular response to lipopolysaccharide (ortholog); defense response to protozoan (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); Chronic Hepatitis B (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22157,926,204 - 157,935,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13157,930,880 - 157,942,229 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,011,675 - 157,019,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,061,505 - 165,068,666 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,061,505 - 165,068,666 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration  (IEA)
cell population proliferation  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to virus  (IEA)
defense response to Gram-positive bacterium  (IEA)
defense response to protozoan  (ISO)
extrinsic apoptotic signaling pathway  (IEA)
immune response  (IEA)
interleukin-12-mediated signaling pathway  (IEA)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA)
negative regulation of protein secretion  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA)
negative regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO)
positive regulation of cell adhesion  (IEA)
positive regulation of dendritic cell chemotaxis  (IEA)
positive regulation of lymphocyte proliferation  (IEA)
positive regulation of mononuclear cell proliferation  (IEA)
positive regulation of natural killer cell activation  (IEA)
positive regulation of natural killer cell mediated cytotoxicity  (IEA)
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IEA)
positive regulation of NK T cell activation  (IEA)
positive regulation of smooth muscle cell apoptotic process  (IEA)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell mediated cytotoxicity  (IEA)
positive regulation of T cell proliferation  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
response to granulocyte colony-stimulating factor  (ISO)
response to lipopolysaccharide  (IEA)
response to UV-B  (IEA)
response to virus  (IEA)
signal transduction  (IEA)
T cell proliferation  (ISO)
T-helper 1 cell activation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
IL12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22157,926,204 - 157,935,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13157,930,880 - 157,942,229 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,011,675 - 157,019,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,061,505 - 165,068,666 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,061,505 - 165,068,666 (+)Ensemblpanpan1.1panPan2
IL12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383159,988,835 - 159,996,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3159,988,835 - 159,996,019 (+)EnsemblGRCh38hg38GRCh38
GRCh373159,706,622 - 159,713,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,189,323 - 161,196,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 343161,189,330 - 161,196,507NCBI
Celera3158,128,398 - 158,135,579 (+)NCBICelera
Cytogenetic Map3q25.33NCBI
HuRef3157,102,994 - 157,110,193 (+)NCBIHuRef
CHM1_13159,669,641 - 159,676,836 (+)NCBICHM1_1
T2T-CHM13v2.03162,763,550 - 162,770,734 (+)NCBIT2T-CHM13v2.0
Il12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39368,597,977 - 68,605,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl368,597,977 - 68,605,880 (+)EnsemblGRCm39 Ensembl
GRCm38368,690,644 - 68,698,550 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl368,690,644 - 68,698,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37368,494,566 - 68,502,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36368,778,573 - 68,786,454 (+)NCBIMGSCv36mm8
Celera368,820,603 - 68,828,506 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map331.92NCBI
Il12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,275,734 - 155,282,997 (+)NCBIGRCr8
mRatBN7.22152,965,769 - 152,973,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,091,860 - 160,098,803 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,142,380 - 158,149,321 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02152,775,143 - 152,782,090 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,076,945 - 165,083,996 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02184,430,744 - 184,437,696 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42158,710,261 - 158,717,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12158,660,223 - 158,667,652 (+)NCBI
Celera2147,317,946 - 147,324,898 (+)NCBICelera
Cytogenetic Map2q32NCBI
Il12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544810,611,131 - 10,617,911 (+)NCBIChiLan1.0ChiLan1.0
IL12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,125,529 - 26,133,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,124,770 - 26,133,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,167,784 - 30,175,056 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,181,526 - 26,189,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,180,963 - 26,189,280 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,112,551 - 26,119,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,072,972 - 26,080,252 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,312,100 - 26,319,473 (+)NCBIUU_Cfam_GSD_1.0
Il12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560283,553,229 - 83,559,894 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,175,261 - 6,180,396 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,166,060 - 6,180,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1399,733,394 - 99,741,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11399,733,394 - 99,741,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,066,792 - 108,074,477 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11530,887,048 - 30,896,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1530,887,897 - 30,894,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660413,416,998 - 3,424,283 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il12a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473037,787,909 - 37,794,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473037,787,772 - 37,794,871 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003830628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000053697   ⟹   ENSPPAP00000030833
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3165,061,505 - 165,068,666 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053704   ⟹   ENSPPAP00000030840
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3165,061,726 - 165,068,206 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000053706   ⟹   ENSPPAP00000030842
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3165,061,726 - 165,068,206 (+)Ensembl
RefSeq Acc Id: XM_003830628   ⟹   XP_003830676
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22157,926,204 - 157,935,673 (+)NCBI
NHGRI_mPanPan13157,930,880 - 157,942,229 (+)NCBI
Mhudiblu_PPA_v03157,011,675 - 157,019,897 (+)NCBI
PanPan1.13165,061,505 - 165,068,666 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003830676 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000030833.1
  ENSPPAP00000030840.1
  ENSPPAP00000030842.1
Reference Protein Sequences
RefSeq Acc Id: XP_003830676   ⟸   XM_003830628
- UniProtKB: A0A2R9BQY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000030833   ⟸   ENSPPAT00000053697
RefSeq Acc Id: ENSPPAP00000030840   ⟸   ENSPPAT00000053704
RefSeq Acc Id: ENSPPAP00000030842   ⟸   ENSPPAT00000053706


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000053697.1 UniProtKB/TrEMBL
  ENSPPAT00000053704.1 UniProtKB/TrEMBL
  ENSPPAT00000053706.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-12_alpha UniProtKB/TrEMBL
KEGG Report pps:100979574 UniProtKB/TrEMBL
NCBI Gene IL12A ENTREZGENE
PANTHER INTERLEUKIN-12 SUBUNIT ALPHA UniProtKB/TrEMBL
  INTERLEUKIN-12 SUBUNIT BETA-RELATED UniProtKB/TrEMBL
Pfam IL12 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A2R9BMD1_PANPA UniProtKB/TrEMBL
  A0A2R9BQY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BWE4_PANPA UniProtKB/TrEMBL