OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF) - Rat Genome Database

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Gene: OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF) Pan paniscus
Analyze
Symbol: OBSCN
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
RGD ID: 12044942
Description: ENCODES a protein that exhibits ankyrin binding (ortholog); phosphatidylinositol bisphosphate binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); ASSOCIATED WITH Autosomal Recessive Nonsyndromic Deafness 120 (ortholog); dilated cardiomyopathy (ortholog); Dwarfism (ortholog); FOUND IN M band (ortholog); sarcomere (ortholog); Z disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103784906; obscurin; uncharacterized LOC103784906; uncharacterized protein LOC103784906
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,227,144 - 21,396,608 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,165,336 - 21,378,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,605,558 - 203,781,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,821,882 - 208,992,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,825,607 - 208,992,246 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
extracellular space  (IEA)
intercalated disc  (IEA)
M band  (IEA,ISO)
membrane  (IEA)
nuclear body  (IEA)
plasma membrane  (IEA)
sarcolemma  (IEA)
sarcomere  (ISO)
Z disc  (IEA,ISO)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
OBSCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,227,144 - 21,396,608 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,165,336 - 21,378,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,605,558 - 203,781,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,821,882 - 208,992,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1208,825,607 - 208,992,246 (+)Ensemblpanpan1.1panPan2
OBSCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,208,044 - 228,378,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,208,044 - 228,378,876 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,395,745 - 228,566,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,462,484 - 226,633,198 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,702,595 - 224,855,685NCBI
Celera1201,585,880 - 201,756,652 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,910,669 - 199,081,449 (+)NCBIHuRef
CHM1_11229,668,122 - 229,838,939 (+)NCBICHM1_1
T2T-CHM13v2.01227,396,836 - 227,567,714 (+)NCBIT2T-CHM13v2.0
Obscn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,885,082 - 59,027,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1158,885,082 - 59,029,996 (-)EnsemblGRCm39 Ensembl
GRCm381158,994,256 - 59,136,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,994,256 - 59,139,170 (-)EnsemblGRCm38mm10GRCm38
MGSCv371158,807,758 - 58,949,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,810,527 - 58,824,805 (-)NCBIMGSCv36mm8
Celera1163,760,680 - 63,901,312 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1136.4NCBI
Obscn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,273,686 - 44,419,275 (-)NCBIGRCr8
mRatBN7.21043,774,113 - 43,919,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,789,293 - 43,919,723 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01045,353,185 - 45,483,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,338,009 - 45,481,008 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,094,419 - 45,240,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,286,791 - 45,432,832 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1043,040,464 - 43,184,409 (-)NCBICelera
Cytogenetic Map10q22NCBI
Obscn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955581148,571 - 265,062 (-)NCBIChiLan1.0ChiLan1.0
OBSCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114664,404 - 782,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14368,668 - 495,174 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014380,493 - 503,404 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.114566,842 - 694,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014327,479 - 475,088 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014337,710 - 460,914 (-)NCBIUU_Cfam_GSD_1.0
LOC101962737
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,601,725 - 87,686,594 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936864619 - 33,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OBSCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,285,488 - 51,534,236 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,317,538 - 51,534,246 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,786,998 - 53,794,594 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OBSCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,356,567 - 1,520,517 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,366,179 - 1,514,668 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,236,221 - 1,403,869 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Obscn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937926,090 - 1,060,233 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000057025   ⟹   ENSPPAP00000034144
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1208,825,607 - 208,992,246 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000057050   ⟹   ENSPPAP00000034169
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1208,825,607 - 208,992,246 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000057064   ⟹   ENSPPAP00000034183
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1208,825,607 - 208,992,246 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000057074   ⟹   ENSPPAP00000034193
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1208,825,607 - 208,974,113 (+)Ensembl
RefSeq Acc Id: XM_055104619   ⟹   XP_054960594
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2121,227,144 - 21,396,608 (-)NCBI
NHGRI_mPanPan1121,165,336 - 21,378,948 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054960594 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000034144.1
  ENSPPAP00000034169.1
  ENSPPAP00000034183.1
  ENSPPAP00000034193.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000034169   ⟸   ENSPPAT00000057050
RefSeq Acc Id: ENSPPAP00000034183   ⟸   ENSPPAT00000057064
RefSeq Acc Id: ENSPPAP00000034144   ⟸   ENSPPAT00000057025
RefSeq Acc Id: ENSPPAP00000034193   ⟸   ENSPPAT00000057074
RefSeq Acc Id: XP_054960594   ⟸   XM_055104619
Protein Domains
DH   Fibronectin type-III   Ig-like   Protein kinase   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057025.1 UniProtKB/TrEMBL
  ENSPPAT00000057050.1 UniProtKB/TrEMBL
  ENSPPAT00000057064.1 UniProtKB/TrEMBL
  ENSPPAT00000057074.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Obscurin_SH3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
NCBI Gene OBSCN ENTREZGENE
PANTHER OBSCURIN UniProtKB/TrEMBL
  SI:DKEY-31G6.6 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BWX3_PANPA UniProtKB/TrEMBL
  A0A2R9BWY3_PANPA UniProtKB/TrEMBL
  A0A2R9C6G6_PANPA UniProtKB/TrEMBL
  A0A2R9C6K4_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 OBSCN  obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF  LOC103784906  uncharacterized LOC103784906  Data merged from RGD:11758920 737654 PROVISIONAL