SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2) - Rat Genome Database

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Gene: SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2) Pan paniscus
Analyze
Symbol: SPSB2
Name: splA/ryanodine receptor domain and SOCS box containing 2
RGD ID: 12036489
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN intracellular signal transduction (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein ubiquitination (inferred); ASSOCIATED WITH Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); SCF ubiquitin ligase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SPRY domain-containing SOCS box protein 2
RGD Orthologs
Human
Chinchilla
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,434,108 - 12,436,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,430,411 - 12,433,446 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,002,783 - 7,005,365 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,913,860 - 6,916,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,914,159 - 6,916,554 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPSB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,434,108 - 12,436,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,430,411 - 12,433,446 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,002,783 - 7,005,365 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,913,860 - 6,916,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,914,159 - 6,916,554 (-)Ensemblpanpan1.1panPan2
SPSB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,875,764 - 6,889,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,870,935 - 6,889,358 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,984,928 - 6,998,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,850,360 - 6,852,713 (-)NCBINCBI36Build 36hg18NCBI36
Celera128,597,386 - 8,599,808 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,833,828 - 6,836,250 (-)NCBIHuRef
CHM1_1126,983,926 - 6,997,543 (-)NCBICHM1_1
T2T-CHM13v2.0126,885,059 - 6,898,618 (-)NCBIT2T-CHM13v2.0
Spsb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,471,696 - 4,474,282 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,471,696 - 4,474,282 (-)NCBIChiLan1.0ChiLan1.0
Spsb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,277,718 - 102,280,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709945,201 - 951,441 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709945,322 - 948,101 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPSB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,836,766 - 63,839,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,836,785 - 63,839,075 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,272,292 - 66,274,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPSB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,904,299 - 6,906,276 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,316,317 - 1,319,260 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spsb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,536,610 - 3,539,106 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,537,255 - 3,539,519 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000046246   ⟹   ENSPPAP00000023422
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl126,914,159 - 6,916,554 (-)Ensembl
RefSeq Acc Id: XM_008973669   ⟹   XP_008971917
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21012,434,108 - 12,436,621 (-)NCBI
NHGRI_mPanPan11212,431,110 - 12,433,326 (-)NCBI
Mhudiblu_PPA_v0127,003,033 - 7,005,255 (-)NCBI
PanPan1.1126,913,860 - 6,916,554 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008973670   ⟹   XP_008971918
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21012,434,108 - 12,436,621 (-)NCBI
NHGRI_mPanPan11212,430,411 - 12,433,325 (-)NCBI
Mhudiblu_PPA_v0127,002,783 - 7,005,254 (-)NCBI
PanPan1.1126,914,159 - 6,916,554 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008971917 (Get FASTA)   NCBI Sequence Viewer  
  XP_008971918 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000023422
  ENSPPAP00000023422.1
Reference Protein Sequences
RefSeq Acc Id: XP_008971917   ⟸   XM_008973669
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008971918   ⟸   XM_008973670
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B822 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000023422   ⟸   ENSPPAT00000046246
Protein Domains
B30.2/SPRY   SOCS box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034889 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000046246.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  SSB2_SOCS UniProtKB/TrEMBL
NCBI Gene SPSB2 ENTREZGENE
PANTHER SPRY DOMAIN CONTAINING SOCS BOX PROTEIN UniProtKB/TrEMBL
  SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 2 UniProtKB/TrEMBL
Pfam SOCS_box UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A2R9B822 ENTREZGENE, UniProtKB/TrEMBL