TXK (TXK tyrosine kinase) - Rat Genome Database

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Gene: TXK (TXK tyrosine kinase) Pan paniscus
Analyze
Symbol: TXK
Name: TXK tyrosine kinase
RGD ID: 12035286
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN NK T cell differentiation (ortholog); positive regulation of cytokine production (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleolus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase TXK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2379,730,977 - 79,801,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1479,992,362 - 80,063,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,039,292 - 74,086,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1484,750,804 - 84,818,671 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl484,750,804 - 84,818,671 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
plasma membrane  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TXK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2379,730,977 - 79,801,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1479,992,362 - 80,063,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,039,292 - 74,086,744 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1484,750,804 - 84,818,671 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl484,750,804 - 84,818,671 (+)Ensemblpanpan1.1panPan2
TXK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38448,066,393 - 48,134,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl448,066,393 - 48,134,250 (-)EnsemblGRCh38hg38GRCh38
GRCh37448,068,410 - 48,136,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,763,167 - 47,831,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 34447,909,688 - 47,977,201NCBI
Celera448,517,268 - 48,584,988 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef447,388,494 - 47,456,038 (-)NCBIHuRef
CHM1_1448,067,554 - 48,135,380 (-)NCBICHM1_1
T2T-CHM13v2.0448,033,459 - 48,101,082 (-)NCBIT2T-CHM13v2.0
Txk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,853,321 - 72,910,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,853,321 - 72,910,120 (-)EnsemblGRCm39 Ensembl
GRCm38572,695,978 - 72,752,992 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,695,978 - 72,752,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv37573,087,217 - 73,144,012 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,975,117 - 73,015,737 (-)NCBIMGSCv36mm8
Celera569,944,742 - 70,002,864 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
Txk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81435,817,270 - 35,873,454 (+)NCBIGRCr8
mRatBN7.21435,463,369 - 35,519,448 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,463,944 - 35,519,448 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,828,243 - 35,884,548 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,132,987 - 37,189,292 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,621,349 - 35,677,656 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,029,809 - 38,085,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,030,189 - 38,085,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,840,106 - 37,896,117 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41437,867,565 - 37,923,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11437,870,891 - 37,926,425 (+)NCBI
Celera1434,718,226 - 34,773,309 (+)NCBICelera
Cytogenetic Map14p11NCBI
Txk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955443474,099 - 556,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955443474,099 - 556,697 (+)NCBIChiLan1.0ChiLan1.0
TXK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11343,911,881 - 43,977,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1343,914,534 - 43,976,655 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1343,865,388 - 43,929,029 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01344,512,768 - 44,576,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1344,514,039 - 44,576,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11344,190,147 - 44,253,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,722,001 - 43,785,908 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01344,605,279 - 44,668,806 (-)NCBIUU_Cfam_GSD_1.0
Txk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528532,066,522 - 32,108,331 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648214,190,409 - 14,245,943 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648214,190,409 - 14,231,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl837,977,986 - 38,046,933 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1837,977,222 - 38,047,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2840,028,569 - 40,096,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1272,120,429 - 2,186,950 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,140,685 - 2,190,398 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604748,133,664 - 48,203,278 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476118,841,795 - 18,897,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476118,841,795 - 18,897,564 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_055111568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000051837   ⟹   ENSPPAP00000028989
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl484,750,804 - 84,818,671 (+)Ensembl
RefSeq Acc Id: XM_055111568   ⟹   XP_054967543
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2379,730,977 - 79,801,494 (+)NCBI
NHGRI_mPanPan1479,992,362 - 80,063,009 (+)NCBI
Protein Sequences
Protein RefSeqs XP_054967543 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000028989.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000028989   ⟸   ENSPPAT00000051837
RefSeq Acc Id: XP_054967543   ⟸   XM_055111568
- UniProtKB: A0A2R9BH56 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037522 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051837.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Txk_SH2 UniProtKB/TrEMBL
  TXK_SH3 UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene TXK ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE TXK UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BH56 ENTREZGENE, UniProtKB/TrEMBL