NEDD4L (NEDD4 like E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: NEDD4L (NEDD4 like E3 ubiquitin protein ligase) Pan paniscus
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Symbol: NEDD4L
Name: NEDD4 like E3 ubiquitin protein ligase
RGD ID: 12034628
Description: ENCODES a protein that exhibits ion channel binding (ortholog); potassium channel inhibitor activity (ortholog); potassium channel regulator activity (ortholog); INVOLVED IN negative regulation of potassium ion transmembrane transport (ortholog); negative regulation of potassium ion transmembrane transporter activity (ortholog); negative regulation of protein localization to cell surface (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH cleft palate (ortholog); dilated cardiomyopathy (ortholog); endometriosis (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: E3 ubiquitin-protein ligase NEDD4-like; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4-like; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11854,762,516 - 55,122,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,867,149 - 55,123,423 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
NEDD4L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11854,762,516 - 55,122,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,867,149 - 55,123,423 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBIMhudiblu_PPA_v0panPan3
NEDD4L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1858,044,226 - 58,401,540 (+)EnsemblGRCh38hg38GRCh38
GRCh381858,044,226 - 58,401,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371855,711,458 - 56,068,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,862,778 - 54,216,369 (+)NCBINCBI36hg18NCBI36
Build 341853,862,777 - 54,216,369NCBI
Celera1852,429,273 - 52,785,147 (+)NCBI
Cytogenetic Map18q21.31NCBI
HuRef1852,421,551 - 52,777,135 (+)NCBIHuRef
CHM1_11855,707,037 - 56,063,999 (+)NCBICHM1_1
Nedd4l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,017,551 - 65,350,897 (+)NCBIGRCm39mm39
GRCm39 Ensembl1865,020,776 - 65,350,899 (+)Ensembl
GRCm381864,884,480 - 65,217,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,887,705 - 65,217,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv371865,047,410 - 65,377,480 (+)NCBIGRCm37mm9NCBIm37
MGSCv361865,149,263 - 65,338,676 (+)NCBImm8
Celera1866,271,347 - 66,493,213 (+)NCBICelera
Cytogenetic Map18E1NCBI
Nedd4l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21858,393,759 - 58,726,709 (+)NCBI
Rnor_6.0 Ensembl1860,392,376 - 60,719,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01860,392,376 - 60,719,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01859,595,643 - 59,921,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,134,242 - 61,477,040 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11861,528,414 - 61,549,290 (+)NCBI
Celera1856,529,040 - 56,853,871 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Nedd4l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,339,380 - 42,688,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,339,380 - 42,688,661 (+)NCBIChiLan1.0ChiLan1.0
NEDD4L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,629,163 - 17,858,471 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,633,591 - 17,950,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,613,069 - 18,951,799 (-)NCBI
ROS_Cfam_1.0117,509,482 - 17,848,443 (-)NCBI
UMICH_Zoey_3.1117,567,699 - 17,905,982 (-)NCBI
UNSW_CanFamBas_1.0117,465,765 - 17,804,137 (-)NCBI
UU_Cfam_GSD_1.0117,733,960 - 18,072,781 (-)NCBI
Nedd4l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,867,247 - 31,171,348 (-)NCBI
SpeTri2.0NW_0049364976,106,284 - 6,318,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,364,055 - 162,737,492 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,364,053 - 162,736,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEDD4L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,326,276 - 21,683,817 (-)NCBI
ChlSab1.1 Ensembl1821,327,567 - 21,683,905 (-)Ensembl
Nedd4l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247923,553,185 - 3,903,288 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032463   ⟹   ENSPPAP00000009819
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,867,149 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032465   ⟹   ENSPPAP00000009821
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,867,149 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032469   ⟹   ENSPPAP00000009825
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,890,221 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032473   ⟹   ENSPPAP00000009829
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,890,221 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032474   ⟹   ENSPPAP00000009830
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,980,901 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032491   ⟹   ENSPPAP00000009846
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1855,043,190 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032505   ⟹   ENSPPAP00000009859
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1855,047,387 - 55,123,423 (+)Ensembl
RefSeq Acc Id: XM_034943815   ⟹   XP_034799706
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,428,364 - 51,789,656 (+)NCBI
RefSeq Acc Id: XM_034943816   ⟹   XP_034799707
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBI
RefSeq Acc Id: XM_034943817   ⟹   XP_034799708
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,556,468 - 51,789,656 (+)NCBI
RefSeq Acc Id: XM_034943818   ⟹   XP_034799709
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,585,837 - 51,789,656 (+)NCBI
RefSeq Acc Id: XM_034943819   ⟹   XP_034799710
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,612,701 - 51,789,656 (+)NCBI
RefSeq Acc Id: XM_034943820   ⟹   XP_034799711
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,639,014 - 51,789,656 (+)NCBI
RefSeq Acc Id: XM_034943821   ⟹   XP_034799712
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,585,826 - 51,792,995 (+)NCBI
RefSeq Acc Id: XM_034943822   ⟹   XP_034799713
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,429,548 - 51,789,656 (+)NCBI
RefSeq Acc Id: XM_034943823   ⟹   XP_034799714
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01851,556,468 - 51,789,656 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_034799707   ⟸   XM_034943816
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034799706   ⟸   XM_034943815
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034799713   ⟸   XM_034943822
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034799714   ⟸   XM_034943823
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034799708   ⟸   XM_034943817
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034799712   ⟸   XM_034943821
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034799709   ⟸   XM_034943818
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034799710   ⟸   XM_034943819
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034799711   ⟸   XM_034943820
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000009846   ⟸   ENSPPAT00000032491
RefSeq Acc Id: ENSPPAP00000009830   ⟸   ENSPPAT00000032474
RefSeq Acc Id: ENSPPAP00000009829   ⟸   ENSPPAT00000032473
RefSeq Acc Id: ENSPPAP00000009825   ⟸   ENSPPAT00000032469
RefSeq Acc Id: ENSPPAP00000009821   ⟸   ENSPPAT00000032465
RefSeq Acc Id: ENSPPAP00000009819   ⟸   ENSPPAT00000032463
RefSeq Acc Id: ENSPPAP00000009859   ⟸   ENSPPAT00000032505
Protein Domains
C2   HECT   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028088 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000009819 UniProtKB/TrEMBL
  ENSPPAP00000009821 UniProtKB/TrEMBL
  ENSPPAP00000009825 UniProtKB/TrEMBL
  ENSPPAP00000009829 UniProtKB/TrEMBL
  ENSPPAP00000009830 UniProtKB/TrEMBL
  ENSPPAP00000009846 UniProtKB/TrEMBL
  ENSPPAP00000009859 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032463 UniProtKB/TrEMBL
  ENSPPAT00000032465 UniProtKB/TrEMBL
  ENSPPAT00000032469 UniProtKB/TrEMBL
  ENSPPAT00000032473 UniProtKB/TrEMBL
  ENSPPAT00000032474 UniProtKB/TrEMBL
  ENSPPAT00000032491 UniProtKB/TrEMBL
  ENSPPAT00000032505 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene NEDD4L ENTREZGENE
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A2R8ZXX2_PANPA UniProtKB/TrEMBL
  A0A2R8ZXX8_PANPA UniProtKB/TrEMBL
  A0A2R8ZXY5_PANPA UniProtKB/TrEMBL
  A0A2R8ZY12_PANPA UniProtKB/TrEMBL
  A0A2R9A3G3_PANPA UniProtKB/TrEMBL
  A0A2R9A3H0_PANPA UniProtKB/TrEMBL
  A0A2R9A3J8_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 NEDD4L  NEDD4 like E3 ubiquitin protein ligase    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED