NEDD4L (NEDD4 like E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: NEDD4L (NEDD4 like E3 ubiquitin protein ligase) Pan paniscus
Analyze
Symbol: NEDD4L
Name: NEDD4 like E3 ubiquitin protein ligase
RGD ID: 12034628
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN establishment of localization in cell (ortholog); negative regulation of sodium ion transport (ortholog); negative regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cleft palate (ortholog); Developmental Disease (ortholog); FOUND IN glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase NEDD4-like; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,577,762 - 75,942,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,270,375 - 61,635,499 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,762,516 - 55,122,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,867,149 - 55,123,423 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
establishment of localization in cell  (ISO)
negative regulation of potassium ion transmembrane transport  (IEA)
negative regulation of protein localization to cell surface  (IEA)
negative regulation of sodium ion transmembrane transport  (IEA)
negative regulation of sodium ion transport  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
positive regulation of caveolin-mediated endocytosis  (ISO)
positive regulation of dendrite extension  (IEA)
positive regulation of protein catabolic process  (ISO)
positive regulation of sodium ion transport  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein K48-linked ubiquitination  (IEA)
protein monoubiquitination  (ISO)
protein polyubiquitination  (IEA)
protein ubiquitination  (IEA)
regulation of bicellular tight junction assembly  (ISO)
regulation of dendrite morphogenesis  (IEA)
regulation of membrane depolarization  (IEA)
regulation of membrane potential  (IEA)
regulation of membrane repolarization  (IEA)
regulation of monoatomic ion transmembrane transport  (IEA)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein stability  (IEA)
regulation of sodium ion transmembrane transport  (IEA)
regulation of sodium ion transport  (ISO)
regulation protein catabolic process at postsynapse  (ISO)
response to salt stress  (ISO)
sodium ion transport  (ISO)
ubiquitin-dependent protein catabolic process  (IEA)
ventricular cardiac muscle cell action potential  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NEDD4L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,577,762 - 75,942,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,270,375 - 61,635,499 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,762,516 - 55,122,236 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,867,149 - 55,123,423 (+)Ensemblpanpan1.1panPan2
NEDD4L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,044,226 - 58,401,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,044,226 - 58,401,540 (+)EnsemblGRCh38hg38GRCh38
GRCh371855,711,458 - 56,068,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,862,778 - 54,216,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341853,862,777 - 54,216,369NCBI
Celera1852,429,273 - 52,785,147 (+)NCBICelera
Cytogenetic Map18q21.31NCBI
HuRef1852,421,551 - 52,777,135 (+)NCBIHuRef
CHM1_11855,707,037 - 56,063,999 (+)NCBICHM1_1
T2T-CHM13v2.01858,244,126 - 58,602,300 (+)NCBIT2T-CHM13v2.0
Nedd4l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,017,551 - 65,350,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,020,776 - 65,350,899 (+)EnsemblGRCm39 Ensembl
GRCm381864,884,480 - 65,217,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,887,705 - 65,217,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv371865,047,410 - 65,377,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,149,263 - 65,338,676 (+)NCBIMGSCv36mm8
Celera1866,271,347 - 66,493,213 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1837.57NCBI
Nedd4l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,663,918 - 60,996,824 (+)NCBIGRCr8
mRatBN7.21858,393,759 - 58,726,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,393,509 - 58,723,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,487,918 - 60,820,828 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01861,186,393 - 61,519,168 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01859,015,711 - 59,343,901 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,392,376 - 60,719,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,392,376 - 60,719,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,595,643 - 59,921,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41861,134,242 - 61,477,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11861,528,414 - 61,549,290 (+)NCBI
Celera1856,529,040 - 56,853,871 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Nedd4l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,339,380 - 42,688,714 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540242,339,380 - 42,688,661 (+)NCBIChiLan1.0ChiLan1.0
NEDD4L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,629,163 - 17,858,471 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,633,591 - 17,950,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha118,613,069 - 18,951,799 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0117,509,482 - 17,848,443 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,509,487 - 17,849,053 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,567,699 - 17,905,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,465,765 - 17,804,137 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,733,960 - 18,072,781 (-)NCBIUU_Cfam_GSD_1.0
Nedd4l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,867,247 - 31,171,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,106,268 - 6,318,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,106,284 - 6,318,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD4L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,364,057 - 162,513,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,364,053 - 162,736,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEDD4L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,326,276 - 21,683,817 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,327,567 - 21,683,905 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660603,882,156 - 4,244,040 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd4l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,553,004 - 3,902,468 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,553,185 - 3,903,288 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034943815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034943823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055102578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055102579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063597339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000032463   ⟹   ENSPPAP00000009819
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,867,149 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032465   ⟹   ENSPPAP00000009821
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,867,149 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032469   ⟹   ENSPPAP00000009825
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,890,221 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032473   ⟹   ENSPPAP00000009829
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,890,221 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032474   ⟹   ENSPPAP00000009830
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1854,980,901 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032491   ⟹   ENSPPAP00000009846
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1855,043,190 - 55,120,352 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032505   ⟹   ENSPPAP00000009859
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1855,047,387 - 55,123,423 (+)Ensembl
RefSeq Acc Id: XM_034943816   ⟹   XP_034799707
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,577,762 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,270,375 - 61,635,499 (+)NCBI
Mhudiblu_PPA_v01851,428,077 - 51,792,995 (+)NCBI
RefSeq Acc Id: XM_034943821   ⟹   XP_034799712
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,735,678 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,428,291 - 61,635,499 (+)NCBI
Mhudiblu_PPA_v01851,585,826 - 51,792,995 (+)NCBI
RefSeq Acc Id: XM_055102578   ⟹   XP_054958553
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,762,614 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,455,225 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_055102579   ⟹   XP_054958554
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,788,890 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,481,502 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_057300459   ⟹   XP_057156442
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,579,505 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,272,149 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_057300460   ⟹   XP_057156443
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,577,870 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,270,489 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_057300461   ⟹   XP_057156444
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,579,211 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,271,824 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_057300462   ⟹   XP_057156445
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,579,136 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,271,750 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_057300463   ⟹   XP_057156446
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,579,269 - 75,942,886 (+)NCBI
NHGRI_mPanPan11861,271,882 - 61,635,499 (+)NCBI
RefSeq Acc Id: XM_063597339   ⟹   XP_063453409
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21775,579,308 - 75,942,886 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034799707   ⟸   XM_034943816
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZXY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034799712   ⟸   XM_034943821
- Peptide Label: isoform X4
- UniProtKB: A0A2R9A3J8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000009846   ⟸   ENSPPAT00000032491
RefSeq Acc Id: ENSPPAP00000009830   ⟸   ENSPPAT00000032474
RefSeq Acc Id: ENSPPAP00000009829   ⟸   ENSPPAT00000032473
RefSeq Acc Id: ENSPPAP00000009825   ⟸   ENSPPAT00000032469
RefSeq Acc Id: ENSPPAP00000009821   ⟸   ENSPPAT00000032465
RefSeq Acc Id: ENSPPAP00000009819   ⟸   ENSPPAT00000032463
RefSeq Acc Id: ENSPPAP00000009859   ⟸   ENSPPAT00000032505
RefSeq Acc Id: XP_054958553   ⟸   XM_055102578
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054958554   ⟸   XM_055102579
- Peptide Label: isoform X4
RefSeq Acc Id: XP_057156443   ⟸   XM_057300460
- Peptide Label: isoform X1
RefSeq Acc Id: XP_057156445   ⟸   XM_057300462
- Peptide Label: isoform X4
RefSeq Acc Id: XP_057156444   ⟸   XM_057300461
- Peptide Label: isoform X3
RefSeq Acc Id: XP_057156446   ⟸   XM_057300463
- Peptide Label: isoform X4
RefSeq Acc Id: XP_057156442   ⟸   XM_057300459
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063453409   ⟸   XM_063597339
- Peptide Label: isoform X4
Protein Domains
C2   HECT   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028088 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032463.1 UniProtKB/TrEMBL
  ENSPPAT00000032465.1 UniProtKB/TrEMBL
  ENSPPAT00000032469.1 UniProtKB/TrEMBL
  ENSPPAT00000032473.1 UniProtKB/TrEMBL
  ENSPPAT00000032474.1 UniProtKB/TrEMBL
  ENSPPAT00000032491.1 UniProtKB/TrEMBL
  ENSPPAT00000032505.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene NEDD4L ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A2R8ZXX2_PANPA UniProtKB/TrEMBL
  A0A2R8ZXX8_PANPA UniProtKB/TrEMBL
  A0A2R8ZXY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZY12_PANPA UniProtKB/TrEMBL
  A0A2R9A3G3_PANPA UniProtKB/TrEMBL
  A0A2R9A3H0_PANPA UniProtKB/TrEMBL
  A0A2R9A3J8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 NEDD4L  NEDD4 like E3 ubiquitin protein ligase    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  Symbol and/or name change 5135510 APPROVED