PEX7 (peroxisomal biogenesis factor 7)

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Gene: PEX7 (peroxisomal biogenesis factor 7) Pan paniscus

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Symbol:

PEX7

Name:

peroxisomal biogenesis factor 7

RGD ID:

12031486

Description:

ENCODES a protein that exhibits enzyme binding (inferred); peroxisome matrix targeting signal-2 binding (inferred); protein homodimerization activity (inferred); INVOLVED IN endochondral ossification (ortholog); fatty acid beta-oxidation (ortholog); neuron migration (ortholog); ASSOCIATED WITH connective tissue disease (ortholog); Familial Behcet-Like Autoinflammatory Syndrome (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); peroxisomal matrix (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	156,789,303 - 156,886,790 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	154,688,006 - 154,785,520 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	134,582,933 - 134,675,388 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	138,671,616 - 138,763,241 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	138,672,179 - 138,762,830 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

connective tissue disease (ISO)

Familial Behcet-Like Autoinflammatory Syndrome (ISO)

genetic disease (ISO)

immunodeficiency 27A (ISO)

intellectual disability (ISO)

Nontuberculous Mycobacterium Infections (ISO)

Peroxisome biogenesis disorder 9B (ISO)

Refsum disease (ISO)

rhizomelic chondrodysplasia punctata (ISO)

rhizomelic chondrodysplasia punctata type 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endochondral ossification (IEA,ISO)

establishment of protein localization to peroxisome (IEA)

ether lipid biosynthetic process (IEA)

fatty acid beta-oxidation (IEA,ISO)

neuron migration (IEA,ISO)

peroxisome organization (IEA)

protein import into peroxisome matrix (IEA,ISO)

protein targeting to peroxisome (IEA,ISO)

protein transport (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

peroxisomal matrix (IEA,ISO)

peroxisome (IEA)

Molecular Function

enzyme binding (IEA)

peroxisome matrix targeting signal-2 binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PEX7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	156,789,303 - 156,886,790 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	154,688,006 - 154,785,520 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	134,582,933 - 134,675,388 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	138,671,616 - 138,763,241 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	138,672,179 - 138,762,830 (+)	Ensembl	panpan1.1		panPan2

PEX7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	136,822,592 - 136,913,934 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	136,822,564 - 136,913,934 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	137,143,730 - 137,235,072 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	137,185,416 - 137,276,752 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	137,185,415 - 137,276,752	NCBI
Celera	6	137,884,169 - 137,975,523 (+)	NCBI		Celera
Cytogenetic Map	6	q23.3	NCBI
HuRef	6	134,707,823 - 134,799,788 (+)	NCBI		HuRef
CHM1_1	6	137,406,427 - 137,497,705 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	138,010,773 - 138,102,113 (+)	NCBI		T2T-CHM13v2.0

Pex7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	19,735,836 - 19,783,420 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	19,729,646 - 19,783,435 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	19,860,090 - 19,907,674 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	19,853,900 - 19,907,689 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	19,579,896 - 19,627,480 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	19,549,941 - 19,597,064 (-)	NCBI		MGSCv36	mm8
Celera	10	19,746,821 - 19,794,378 (-)	NCBI		Celera
Cytogenetic Map	10	A3	NCBI
cM Map	10	9.16	NCBI

Pex7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	16,402,319 - 16,466,304 (-)	NCBI		GRCr8
mRatBN7.2	1	14,582,698 - 14,646,686 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	14,582,699 - 14,646,748 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	14,348,315 - 14,411,509 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	20,350,176 - 20,413,370 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	14,562,842 - 14,626,565 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	15,311,768 - 15,374,702 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	15,311,770 - 15,374,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	16,860,051 - 16,922,985 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	15,099,265 - 15,163,734 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	15,099,726 - 15,164,133 (-)	NCBI
Celera	1	13,025,130 - 13,088,349 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

Pex7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	71,302 - 138,278 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	71,302 - 138,278 (-)	NCBI	ChiLan1.0	ChiLan1.0

PEX7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	29,337,362 - 29,423,608 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	29,337,386 - 29,418,126 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	30,219,935 - 30,306,081 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	29,498,397 - 29,584,630 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	29,498,392 - 29,579,297 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	29,383,397 - 29,469,537 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	29,268,567 - 29,354,722 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	29,567,702 - 29,653,770 (+)	NCBI		UU_Cfam_GSD_1.0

Pex7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	124,458,474 - 124,523,416 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936560	4,237,642 - 4,303,286 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936560	4,237,691 - 4,302,655 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PEX7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	27,257,011 - 27,346,515 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	27,257,872 - 27,346,529 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	30,684,925 - 30,769,689 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PEX7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	36,486,636 - 36,585,662 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	36,485,513 - 36,585,736 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	8,673,563 - 8,768,133 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pex7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624886	876,787 - 944,911 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624886	877,359 - 944,365 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008953041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034962929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000035768 ⟹ ENSPPAP00000013100

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	138,672,179 - 138,762,830 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000035770 ⟹ ENSPPAP00000013102

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	6	138,672,179 - 138,679,345 (+)	Ensembl

RefSeq Acc Id:

XM_008953041 ⟹ XP_008951289

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	156,789,303 - 156,881,623 (+)	NCBI
NHGRI_mPanPan1	6	154,688,006 - 154,785,520 (+)	NCBI
Mhudiblu_PPA_v0	6	134,582,933 - 134,675,388 (+)	NCBI
PanPan1.1	6	138,671,616 - 138,763,241 (+)	NCBI

Sequence:

show sequence

TGGAGTTGGTGTTTCATCTTTTCCAGTTACAGTGTGAAAGTAGCCCACCAGCCCACGCTCTTAT
TCCTAAAGACCGCAGTGACTCCACGGAGTTAAGTTATCATTGCTTCCAGTTTCCTTGGGCAACG
CAGCACGCAATTTTGGACGCGCTGCGTGGTTTCAGAGTCGGCTGTAACTTTTCTCACTTTATAG
TCATCAGGAAAAGTTCCTGATGCCAGTCTTCCAAACGCTCAATGAAATAAAAACCAGATAGCAC
CGCAGAGGAGGTTGAGATGCAACGACAAAAGCTGTCGTAATTATTAATAATACCTAACCCTGGA
TCACTCCCCTGATAGATCTGTATCTTTGCAGCAGGCGCAATTCAGTTTGGTTTCACCCAAAACA
AAAATGGTCTCCGTCGGAGTCAATGCCCTTTCCTGTGCGGACCAATCAGAATCTCAAACACAAG
GCACGGGGCCCACACTTCCGTCCGGTCTTCCTGGTCTCTCTAACCGCGGCAGTGTGCCTCCGAC
TCGGAACGGCTTCCGCGGCCGGGGCAGCGAGGGCCGGGGGCGGCGGGCGGGATGAGTGCGGTGT
GCGGTGGAGCGGCGCGGACGCTGCGGACGCCGGGACGCCACGGCTACGCCGCCGAGTTCTCCCC
GTACCTTCCGGGCCGCCTGGCCTGCGCCACCGCGCAGCACTACGGCATCGCGGGCTGTGGAACC
CTACTAATATTGGATCCAGATGAAGCTGGGCTAAGGCTTTTTAGAAGCTTTGACTGGAATGATG
GTTTGTTTGATGTGACTTGGAGTGAGAACAACGAACATGTCCTCATCACCTGTAGTGGCGATGG
CTCGCTGCAGCTCTGGGACACTGCCAAAGCTGCAGAGCCACTGCAAGTCTATAAAGAACACGCT
CAGGAGGTGTATAGTGTTGATTGGAGCCAAACCAGAGGTGAACAGCTTGTGGTGTCTGGCTCAT
GGGATCAAACTGTCAAATTGTGGGATCCAACTGTTGGAAAGTCTCTGTGCACCTTTAGAGGCCA
TGAAAGTATTATTTATAGCACAATCTGGTCTCCCCACATCCCTGGTTGTTTTGCTTCAGCCTCA
GGTGATCAGACTCTGAGAATATGGGATGTGAAGGCAGCAGGAGTAAGAATCGTGATTCCTGCAC
ATCAGGCAGAAATCTTGAGTTGTGACTGGTGTAAATACAGTGAGAATTTGCTGGTGACCGGGGC
GGTTGACTGTAGTTTGAGAGGCTGGGACTTAAGGAATGTACGACAACCAGTGTTTGAACTTCTT
GGTCATACCTATGCTATTAGGAGGGTGAAATTTTCGCCATTTCATGCTTCTGTGCTGGCCTCTT
GCTCGTATGATTTTACTGTAAGATTCTGGAACTTTTCAAAGCCTGACTCTCTTCTTGAAACAGT
GGAGCATCATACAGAGTTTACTTGTGGTTTAGACTTCAGTCTTCAGAGCCCCACTCAGGTGGCT
GACTGTTCTTGGGATGAAACAATAAAGATCTATGACCCTGCTTGTCTTACTATTCCTGCTTGAG
ATACACTACTTTGGTCAGAAACAGAGGATGTTGGCTGAAGAACTGCCTAACAGCAAATAAATTA
ACTATGGAAAACATAGACATTATGCTTTTATATGCTATTCAGATTTCAAATCTTCCCAATTTAC
CCTGGAATCAGTTTTGAGGGAGCTGATAAAGACTTTAGCTGACTCGTTAAGCCTGATACATAAG
CCATATTTAAAATTCTAAGAAATAATTAACGTTATGATATATCTTGTAATATCTATTAAAATGT
AGTCTCTGGGTCATAAAATGGATTAAAATATGGGAGATCAGTAGGTTATACTTATATAGATAGT
GATATATTTCATTTTTAATTTGTCATTTTTGATGTAAAATATAATCACTGCTGTGATAAATAAA
CTATCTATTGATCATTTATCATTTTA

hide sequence

RefSeq Acc Id:

XM_034962929 ⟹ XP_034818820

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	5	156,789,303 - 156,886,790 (+)	NCBI
NHGRI_mPanPan1	6	154,688,006 - 154,785,520 (+)	NCBI
Mhudiblu_PPA_v0	6	134,582,933 - 134,675,388 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008951289	(Get FASTA)	NCBI Sequence Viewer
	XP_034818820	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000013100
	ENSPPAP00000013100.1
	ENSPPAP00000013102.1

RefSeq Acc Id:	XP_008951289 ⟸ XM_008953041
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9A875 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSAVCGGAARTLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSF DWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAEPLQVYKEHAQEVYSVDWSQTRGEQLV VSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRI VIPAHQAEILSCDWCKYSENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHAS VLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPACLT IPA hide sequence

RefSeq Acc Id:	XP_034818820 ⟸ XM_034962929
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A875 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000013100 ⟸ ENSPPAT00000035768

Ensembl Acc Id:

ENSPPAP00000013102 ⟸ ENSPPAT00000035770

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029707	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035768.1	UniProtKB/TrEMBL
	ENSPPAT00000035770.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	PEX7	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	PEX7	ENTREZGENE
PANTHER	PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR	UniProtKB/TrEMBL
	PTHR46027	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A2R9A875	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9ACA7_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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