ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

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Gene: ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide) Pan paniscus

Analyze

Symbol:

ADH5

Name:

alcohol dehydrogenase 5 (class III), chi polypeptide

RGD ID:

12024179

Description:

ENCODES a protein that exhibits alcohol dehydrogenase (NAD+) activity (ortholog); INVOLVED IN aging (ortholog); ethanol catabolic process (ortholog); formaldehyde catabolic process (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); AMED syndrome (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

alcohol dehydrogenase class-3

RGD Orthologs

Human

Mouse

Rat

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	102,134,375 - 102,151,902 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	102,134,375 - 102,151,902 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	91,470,304 - 91,487,854 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

AMED syndrome (ISO)

asthma (ISO)

cholestasis (ISO)

pulmonary hypertension (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

alcohol metabolic process (IEA)

ethanol catabolic process (ISO)

ethanol oxidation (IEA)

fatty acid omega-oxidation (IEA)

formaldehyde catabolic process (IEA,ISO)

peptidyl-cysteine S-nitrosylation (IEA,ISO)

positive regulation of blood pressure (IEA,ISO)

respiratory system process (IEA,ISO)

response to lipopolysaccharide (IEA,ISO)

response to nitrosative stress (IEA,ISO)

response to redox state (IEA)

retinoid metabolic process (IEA,ISO)

Cellular Component

cytoplasm (ISO)

mitochondrion (IEA)

nucleus (ISO)

Molecular Function

alcohol dehydrogenase (NAD+) activity (IEA,ISO)

alcohol dehydrogenase [NAD(P)+] activity (IEA)

fatty acid binding (IEA)

formaldehyde dehydrogenase activity (IEA)

identical protein binding (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

S-(hydroxymethyl)glutathione dehydrogenase activity (IEA)

S-(hydroxymethyl)glutathione dehydrogenase NAD activity (IEA)

S-(hydroxymethyl)glutathione dehydrogenase NADP activity (IEA)

zinc ion binding (IEA)

References

Genomics

Comparative Map Data

ADH5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	102,134,375 - 102,151,902 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	102,134,375 - 102,151,902 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	91,470,304 - 91,487,854 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ADH5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	99,070,978 - 99,088,788 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	99,070,978 - 99,088,801 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	99,992,129 - 100,009,939 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	100,211,152 - 100,228,954 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	100,349,540 - 100,367,191	NCBI
Celera	4	97,289,594 - 97,307,408 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI
HuRef	4	95,730,971 - 95,748,768 (-)	NCBI		HuRef
CHM1_1	4	99,969,101 - 99,986,899 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	102,385,880 - 102,403,688 (-)	NCBI		T2T-CHM13v2.0

Adh5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	138,142,961 - 138,161,260 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	138,148,854 - 138,161,260 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	138,437,200 - 138,455,499 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	138,443,093 - 138,455,499 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	138,106,128 - 138,118,463 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	138,380,551 - 138,392,886 (+)	NCBI		MGSCv36	mm8
Celera	3	144,865,856 - 144,878,188 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI

Adh5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	226,975,184 - 226,987,591 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	226,947,466 - 226,987,591 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	234,723,921 - 234,736,337 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	232,623,648 - 232,636,062 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	227,488,332 - 227,500,747 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	243,728,500 - 243,740,907 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	243,700,784 - 243,740,899 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	262,262,936 - 262,275,343 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	235,979,108 - 235,991,515 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	219,131,229 - 219,143,636 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

ADH5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	21,249,459 - 21,261,130 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	21,249,739 - 21,265,048 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	20,665,071 - 20,680,669 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	21,435,360 - 21,451,154 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	21,432,077 - 21,451,233 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	21,401,221 - 21,416,820 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	21,228,031 - 21,243,728 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	18,651,920 - 18,667,674 (+)	NCBI		UU_Cfam_GSD_1.0

ADH5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	121,266,764 - 121,282,310 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	121,266,794 - 121,282,313 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	130,451,304 - 130,466,904 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADH5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	47,190,031 - 47,211,670 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	47,190,294 - 47,211,651 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	25,620,607 - 25,643,036 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adh5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004625024	32,348 - 63,242 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004625024	32,237 - 60,983 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003829923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000034002 ⟹ ENSPPAP00000011347

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	102,134,375 - 102,151,902 (-)	Ensembl

RefSeq Acc Id:

XM_003829923 ⟹ XP_003829971

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	4	102,134,375 - 102,151,902 (-)	NCBI
Mhudiblu_PPA_v0	4	91,470,304 - 91,487,854 (-)	NCBI

Sequence:

show sequence

CGCCCCCCTCGCTAGGCGCTCGCCACGCCCATGCCTCCGTCGCTGCGCGGCCCACCCCGGATGT
CAGCCCCCCGCGCCGACCAGAATCCGTGAACATGGCGAACGAGGTTATCAAGTGCAAGGCTGCA
GTTGCTTGGGAGGCTGGAAAGCCTCTCTCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTC
ATGAAGTTCGAATCAAGATCATTGCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGG
AGCTGATCCTGAGGGTTGTTTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGT
GTTGGTGAGGGAGTTACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGT
GTGGACAATGCAAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCA
AGGGAAAGGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCAT
TACATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATAG
ATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTATGGTGC
TGCTGTGAACACTGCCAAGGTGGAGCCTGGCTCTGTTTGTGCTGTCTTTGGTCTGGGAGGAGTC
GGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATTGGTGTGGACATCA
ATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGTATTAACCCTCAGGATTT
TAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGAGGAGTGGACTATTCCTTTGAA
TGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAGGCATGTCACAAGGGCTGGGGCGTCA
GCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAAATTGCCACTCGTCCATTCCAGCTGGTAAC
AGGTCGCACATGGAAAGGCACTGCCTTTGGAGGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTG
GTGTCTGAATATATGTCCAAAAAGATAAAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTG
ATGAAATCAACAAAGCCTTTGAACTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGAT
TTAATTCAAAAGAGAAAAATAATGTCCATCCTGTCGTGATGTGATAGGAGCAGCTTAACAGGCA
GGGAGAAGCGCCTCCAACCTCACAGCCTCGTAGAGCTTCACAGCTACTCCAGAGAATAGGGTTA
TGTGTGTAATTCATGAATCTCTATAATCAAGGACAAGGATAATTCAGTCATGAACCTGTTTTCT
GGATGCTCCTCCACATAAATAATTGCTAGCTTATTAAGGAATATTTTAACATAATAAAAGTAAT
TTCTACATTTGTGTGGAAATTGTCTTCTTTGTTTTATGCTGTCATCATTGTCACGGTTTGTCTG
CCCATTATCTTCATTCTGCAAGGGAAAGGGAAAGGAAGCAGGGCAGTGGTGGGTGTCTGAAACC
TCAGAAACATAACGTTGAACTTTTAAGGGTCTCAGTCCCCGTTGATTAAAGAACAGATCCTAGC
CATCAGTGACAAAGTTAATCAGGACCCAAGTCTGCTTCTGTGATATTATCTTGAAGGGAGGTAC
TGTGCCTTGTTCATACCTGTACCCCAAATTCCTAGGATGGCATCTGCCCTTCAGGGGGCACTAA
AATGTATTATTGAAACAGCATTCTGGGCTTAAATAGGTGTATGTGTGTGTTGGTTGTGACTGTA
CTATTTCTAGTATAGTGAACTACATACTGAATATCCAAGTTCTCAGCACCTACTTTTGTCAAAT
CTTAACATTTTGCCACTTCGAGATCACATTGCCATTCCTCCCCTCCAGAGGTAACAATTATCCA
CAATTTGATGTTTATCATTCCTGTGTTGTTGTACTTTCACTGTGTATAACCTAAACCATCTACT
CTTTAGTACTGTTTTATATATTTTTAAGCCTTATACTTGCTCATTCTACAGCTTTTTTCACTCA
TTATTGTATAATTACATCTGAAGCTCTCGTTCATTAATTTTAGTCCTGTGTAGCAGAATTCAAT
TACGGGAACTACCGTAATTTATCTGTTCTCCAGTTGAAGGCATGAAGTTGTTGCCAGTTTCTGT
ATTATAACACTGTAGTGGAACATTCTTCTGCATTGGGCTCACTGCGTGTTACCTAAGACATGTA
TCACAGAATAAACACATTTAGCCTTATAGACATTGCCAAATTGCTCTTCAAAGTAAATGTGAGT
TTTTGTGAATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003829971	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003829971 ⟸ XM_003829923

- Sequence:

show sequence

MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVI
LGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGQCKFCLNPKTNLCQKIRVTQGKGLMPDGTS
RFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKVEPG
SVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIE
MTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFG
GWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI

hide sequence

RefSeq Acc Id:

ENSPPAP00000011347 ⟸ ENSPPAT00000034002

Protein Domains

Enoyl reductase (ER)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000028876	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000011347.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000034002.1	UniProtKB/TrEMBL
InterPro	ADH_3	UniProtKB/TrEMBL
	ADH_C	UniProtKB/TrEMBL
	ADH_N	UniProtKB/TrEMBL
	ADH_Zn_CS	UniProtKB/TrEMBL
	GroES-like_sf	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	PKS_ER	UniProtKB/TrEMBL
NCBI Gene	ADH5	ENTREZGENE
Pfam	ADH_N	UniProtKB/TrEMBL
	ADH_zinc_N	UniProtKB/TrEMBL
PROSITE	ADH_ZINC	UniProtKB/TrEMBL
SMART	PKS_ER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50129	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
TIGRFAMs	adh_III_F_hyde	UniProtKB/TrEMBL
UniProt	A0A2R9A243_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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