TOP3A (DNA topoisomerase III alpha) - Rat Genome Database

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Gene: TOP3A (DNA topoisomerase III alpha) Pan paniscus
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Symbol: TOP3A
Name: DNA topoisomerase III alpha
RGD ID: 12023678
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA topoisomerase activity (inferred); DNA topoisomerase type I (single strand cut, ATP-independent) activity (inferred); INVOLVED IN chromosome separation (inferred); DNA recombination (inferred); DNA repair (inferred); ASSOCIATED WITH autistic disorder (ortholog); autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (ortholog); Birt-Hogg-Dube syndrome (ortholog); FOUND IN chromosome (inferred); mitochondrion (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase 3-alpha; topoisomerase (DNA) III alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21952,952,701 - 52,992,008 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,663,697 - 57,702,988 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,814,448 - 32,858,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11737,897,009 - 37,940,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,897,037 - 37,936,135 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TOP3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21952,952,701 - 52,992,008 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,663,697 - 57,702,988 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,814,448 - 32,858,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11737,897,009 - 37,940,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,897,037 - 37,936,135 (+)Ensemblpanpan1.1panPan2
TOP3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,271,428 - 18,314,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,271,428 - 18,315,007 (-)EnsemblGRCh38hg38GRCh38
GRCh371718,174,742 - 18,218,308 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,117,960 - 18,159,046 (-)NCBINCBI36Build 36hg18NCBI36
Build 341718,117,959 - 18,159,046NCBI
Celera1719,118,328 - 19,159,392 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,930,468 - 17,971,853 (-)NCBIHuRef
CHM1_11718,186,015 - 18,227,080 (-)NCBICHM1_1
T2T-CHM13v2.01718,218,234 - 18,261,800 (-)NCBIT2T-CHM13v2.0
Top3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,629,014 - 60,668,099 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,630,884 - 60,668,191 (-)EnsemblGRCm39 Ensembl
GRCm381160,738,209 - 60,777,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,740,058 - 60,777,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,553,561 - 60,590,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,556,254 - 60,593,560 (-)NCBIMGSCv36mm8
Celera1165,000,916 - 65,014,847 (-)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Top3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,915,625 - 45,956,856 (-)NCBIGRCr8
mRatBN7.21045,419,219 - 45,457,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,419,217 - 45,457,559 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01046,980,646 - 47,018,728 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,981,958 - 47,018,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,753,640 - 46,790,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,886,319 - 46,923,435 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,899,953 - 46,910,769 (-)NCBI
Celera1044,674,374 - 44,711,934 (-)NCBICelera
Cytogenetic Map10q22NCBI
Top3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,015,378 - 11,045,717 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,015,378 - 11,045,717 (+)NCBIChiLan1.0ChiLan1.0
TOP3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,262,820 - 41,290,101 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,263,017 - 41,290,100 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,402,359 - 41,429,772 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,369,773 - 41,397,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,369,812 - 41,397,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,337,253 - 41,364,659 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,284,891 - 41,312,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,476,514 - 41,503,926 (+)NCBIUU_Cfam_GSD_1.0
Top3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,028,399 - 61,060,114 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,809,909 - 1,838,734 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,809,371 - 1,838,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,443,677 - 60,468,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,443,592 - 60,468,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TOP3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,315,466 - 17,358,863 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,316,048 - 17,358,580 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,546,742 - 3,586,745 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,159,810 - 3,194,860 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,159,432 - 3,196,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000028436   ⟹   ENSPPAP00000006765
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1737,897,037 - 37,936,135 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000028445   ⟹   ENSPPAP00000006768
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1737,897,313 - 37,905,219 (+)Ensembl
RefSeq Acc Id: XM_003809778   ⟹   XP_003809826
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21952,952,701 - 52,992,008 (+)NCBI
NHGRI_mPanPan11757,663,697 - 57,702,988 (+)NCBI
Mhudiblu_PPA_v01732,814,448 - 32,858,076 (-)NCBI
PanPan1.11737,897,009 - 37,940,446 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034942294   ⟹   XP_034798185
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21952,953,297 - 52,992,008 (+)NCBI
NHGRI_mPanPan11757,664,412 - 57,702,988 (+)NCBI
Mhudiblu_PPA_v01732,814,448 - 32,858,076 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003809826 (Get FASTA)   NCBI Sequence Viewer  
  XP_034798185 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000006765.1
  ENSPPAP00000006768.1
RefSeq Acc Id: XP_003809826   ⟸   XM_003809778
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZPA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034798185   ⟸   XM_034942294
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZPA3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000006765   ⟸   ENSPPAT00000028436
Ensembl Acc Id: ENSPPAP00000006768   ⟸   ENSPPAT00000028445
Protein Domains
GRF-type   Toprim


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000025639 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000028436.1 UniProtKB/TrEMBL
  ENSPPAT00000028445.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.290.10 UniProtKB/TrEMBL
  1.10.460.10 UniProtKB/TrEMBL
  2.70.20.10 UniProtKB/TrEMBL
  3.40.50.140 UniProtKB/TrEMBL
  Bacterial Topoisomerase I, domain 1 UniProtKB/TrEMBL
InterPro Topo_IA UniProtKB/TrEMBL
  Topo_IA_2 UniProtKB/TrEMBL
  Topo_IA_AS UniProtKB/TrEMBL
  Topo_IA_cen UniProtKB/TrEMBL
  Topo_IA_cen_sub1 UniProtKB/TrEMBL
  Topo_IA_cen_sub2 UniProtKB/TrEMBL
  Topo_IA_cen_sub3 UniProtKB/TrEMBL
  Topo_IA_core_domain UniProtKB/TrEMBL
  Topo_IA_DNA-bd_dom UniProtKB/TrEMBL
  Topo_IA_Znf UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/TrEMBL
  TOPRIM_TopoIII UniProtKB/TrEMBL
  Znf_GRF UniProtKB/TrEMBL
KEGG Report pps:100970853 UniProtKB/TrEMBL
NCBI Gene TOP3A ENTREZGENE
PANTHER DNA TOPOISOMERASE 3-ALPHA UniProtKB/TrEMBL
  PTHR11390 UniProtKB/TrEMBL
Pfam Topoisom_bac UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
  zf-C4_Topoisom UniProtKB/TrEMBL
  zf-GRF UniProtKB/TrEMBL
PRINTS PRTPISMRASEI UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_I_PROK UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
  ZF_GRF UniProtKB/TrEMBL
SMART TOP1Ac UniProtKB/TrEMBL
  TOP1Bc UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
Superfamily-SCOP SSF56712 UniProtKB/TrEMBL
  Zinc beta-ribbon UniProtKB/TrEMBL
UniProt A0A2R8ZPA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZSB9_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 TOP3A  DNA topoisomerase III alpha    topoisomerase (DNA) III alpha  Symbol and/or name change 5135510 APPROVED