PNKP (polynucleotide kinase 3'-phosphatase) - Rat Genome Database

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Gene: PNKP (polynucleotide kinase 3'-phosphatase) Pan paniscus
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Symbol: PNKP
Name: polynucleotide kinase 3'-phosphatase
RGD ID: 12020471
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN DNA damage response (ortholog); protein K63-linked ubiquitination (ortholog); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; ASSOCIATED WITH ataxia with oculomotor apraxia type 1 (ortholog); ataxia-oculomotor apraxia type 4 (ortholog); Charcot-Marie-Tooth disease type 2B2 (ortholog); FOUND IN SCF ubiquitin ligase complex (ortholog); site of double-strand break (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bifunctional polynucleotide phosphatase/kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,976,831 - 55,983,568 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,897,620 - 57,904,351 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,874,216 - 46,880,954 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,790,048 - 55,796,762 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,790,048 - 55,796,762 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PNKP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,976,831 - 55,983,568 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,897,620 - 57,904,351 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,874,216 - 46,880,954 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,790,048 - 55,796,762 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,790,048 - 55,796,762 (-)Ensemblpanpan1.1panPan2
PNKP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,861,204 - 49,867,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,859,882 - 49,878,351 (-)EnsemblGRCh38hg38GRCh38
GRCh371950,364,461 - 50,370,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,056,273 - 55,062,630 (-)NCBINCBI36Build 36hg18NCBI36
Build 341955,056,273 - 55,062,630NCBI
Celera1947,233,911 - 47,240,265 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,740,801 - 46,747,159 (-)NCBIHuRef
CHM1_11950,366,296 - 50,372,658 (-)NCBICHM1_1
T2T-CHM13v2.01952,861,341 - 52,867,713 (-)NCBIT2T-CHM13v2.0
Pnkp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,505,903 - 44,514,761 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,506,563 - 44,512,416 (+)EnsemblGRCm39 Ensembl
GRCm38744,856,479 - 44,865,337 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,857,139 - 44,862,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,112,551 - 52,118,299 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,725,446 - 44,730,692 (+)NCBIMGSCv36mm8
Celera740,307,378 - 40,313,138 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.94NCBI
Pnkp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,476,801 - 104,483,409 (+)NCBIGRCr8
mRatBN7.2195,341,465 - 95,346,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,341,620 - 95,346,920 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,727,009 - 100,732,021 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,199,674 - 109,204,686 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,490,083 - 102,495,095 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,853,475 - 100,859,202 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,853,902 - 100,859,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,918,355 - 101,923,823 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,330,455 - 95,335,468 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,408,565 - 95,413,578 (+)NCBI
Celera189,603,379 - 89,608,363 (+)NCBICelera
Cytogenetic Map1q22NCBI
Pnkp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,064,924 - 1,070,120 (+)NCBIChiLan1.0ChiLan1.0
PNKP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,695,649 - 106,707,229 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,694,589 - 106,702,150 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,279,042 - 106,290,146 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,217,048 - 107,228,155 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,216,020 - 107,223,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,889,136 - 106,900,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,531,152 - 106,542,223 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,371,601 - 107,382,705 (+)NCBIUU_Cfam_GSD_1.0
Pnkp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,030,811 - 22,037,942 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,649,833 - 3,656,035 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,649,020 - 3,656,545 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNKP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,867,637 - 54,881,088 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,870,359 - 54,880,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,603,437 - 50,609,911 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNKP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,018,763 - 43,025,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,018,807 - 43,025,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,994,046 - 23,000,503 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnkp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,462,766 - 4,467,616 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,462,675 - 4,467,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000013672   ⟹   ENSPPAP00000002910
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1955,790,048 - 55,796,762 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000013752   ⟹   ENSPPAP00000002940
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1955,790,048 - 55,796,089 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000013780   ⟹   ENSPPAP00000002945
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1955,790,092 - 55,796,089 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000013785   ⟹   ENSPPAP00000002949
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1955,790,092 - 55,796,089 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000013791   ⟹   ENSPPAP00000002953
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1955,790,092 - 55,796,089 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000013816   ⟹   ENSPPAP00000002956
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1955,793,116 - 55,796,089 (-)Ensembl
RefSeq Acc Id: XM_003814346   ⟹   XP_003814394
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22055,976,831 - 55,983,545 (-)NCBI
NHGRI_mPanPan11957,897,620 - 57,904,088 (-)NCBI
Mhudiblu_PPA_v01946,874,216 - 46,880,681 (-)NCBI
PanPan1.11955,790,048 - 55,796,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034945442   ⟹   XP_034801333
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22055,976,831 - 55,983,568 (-)NCBI
NHGRI_mPanPan11957,897,620 - 57,904,351 (-)NCBI
Mhudiblu_PPA_v01946,874,216 - 46,880,954 (-)NCBI
RefSeq Acc Id: XM_063600522   ⟹   XP_063456592
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22055,976,831 - 55,983,202 (-)NCBI
RefSeq Acc Id: XP_003814394   ⟸   XM_003814346
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034801333   ⟸   XM_034945442
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000002910   ⟸   ENSPPAT00000013672
RefSeq Acc Id: ENSPPAP00000002949   ⟸   ENSPPAT00000013785
RefSeq Acc Id: ENSPPAP00000002945   ⟸   ENSPPAT00000013780
RefSeq Acc Id: ENSPPAP00000002940   ⟸   ENSPPAT00000013752
RefSeq Acc Id: ENSPPAP00000002953   ⟸   ENSPPAT00000013791
RefSeq Acc Id: ENSPPAP00000002956   ⟸   ENSPPAT00000013816
RefSeq Acc Id: XP_063456592   ⟸   XM_063600522
- Peptide Label: isoform X3
Protein Domains
PNK FHA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000012210 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000013672.1 UniProtKB/TrEMBL
  ENSPPAT00000013752.1 UniProtKB/TrEMBL
  ENSPPAT00000013780.1 UniProtKB/TrEMBL
  ENSPPAT00000013785.1 UniProtKB/TrEMBL
  ENSPPAT00000013791.1 UniProtKB/TrEMBL
  ENSPPAT00000013816.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro FHA_2 UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD-SF_hydro_IIIA UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PNK3P UniProtKB/TrEMBL
  PNKP UniProtKB/TrEMBL
  Polynucleotide_phosphatase UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
NCBI Gene PNKP ENTREZGENE
PANTHER BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE UniProtKB/TrEMBL
  BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/TrEMBL
  FHA_2 UniProtKB/TrEMBL
  PNK3P UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF56784 UniProtKB/TrEMBL
UniProt A0A2R8ZCX7_PANPA UniProtKB/TrEMBL
  A0A2R8ZD04_PANPA UniProtKB/TrEMBL
  A0A2R8ZD10_PANPA UniProtKB/TrEMBL
  A0A2R8ZD30_PANPA UniProtKB/TrEMBL
  A0A2R8ZGW3_PANPA UniProtKB/TrEMBL
  A0A2R8ZJR2_PANPA UniProtKB/TrEMBL