LYZ (lysozyme) - Rat Genome Database

Name: LYZ
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: LYZ (lysozyme) Pan paniscus

Analyze

Symbol:

LYZ

Name:

lysozyme

RGD ID:

12019181

Description:

ENCODES a protein that exhibits hydrolase activity, acting on glycosyl bonds (ortholog); lysozyme activity (ortholog); INVOLVED IN defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH Familial Amyloidosis (ortholog); familial visceral amyloidosis (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); Golgi cis cisterna (ortholog); Golgi stack (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

1,4-beta-N-acetylmuramidase C; lysozyme c; LZM

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LYZ (lysozyme)	NCBI	Ortholog
Mus musculus (house mouse):	Lyz2 (lysozyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lyz2 (lysozyme 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LYZ (lysozyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101959346 (lysozyme C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LYZ (lysozyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LYZ (lysozyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lyz (lysozyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	77,375,766 - 77,381,645 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	77,372,162 - 77,378,043 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	66,870,373 - 66,876,250 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	69,646,794 - 69,652,677 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	69,646,794 - 69,652,677 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Familial Amyloidosis (ISO)

familial visceral amyloidosis (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to bacterium (IEA)

defense response to Gram-negative bacterium (IEA,ISO)

defense response to Gram-positive bacterium (IEA,ISO)

killing of cells of another organism (IEA)

Cellular Component

endoplasmic reticulum lumen (ISO)

extracellular region (IEA)

extracellular space (IEA)

Golgi cis cisterna (ISO)

Golgi stack (ISO)

microvillus (ISO)

rough endoplasmic reticulum lumen (ISO)

secretory granule (ISO)

trans-Golgi network transport vesicle (ISO)

Molecular Function

catalytic activity (IEA)

hydrolase activity (IEA)

hydrolase activity, acting on glycosyl bonds (IEA,ISO)

identical protein binding (IEA)

lysozyme activity (IEA,ISO)

References

Additional References at PubMed

PMID:8990116	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LYZ
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	77,375,766 - 77,381,645 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	77,372,162 - 77,378,043 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	66,870,373 - 66,876,250 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	69,646,794 - 69,652,677 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	69,646,794 - 69,652,677 (+)	Ensembl	panpan1.1		panPan2

LYZ
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	69,348,381 - 69,354,234 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	69,348,381 - 69,354,234 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	69,742,161 - 69,748,014 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	68,028,431 - 68,034,280 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	68,028,430 - 68,034,280	NCBI
Celera	12	69,405,811 - 69,411,693 (+)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI
HuRef	12	66,791,650 - 66,797,534 (+)	NCBI		HuRef
CHM1_1	12	69,710,537 - 69,716,432 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	69,327,311 - 69,333,169 (+)	NCBI		T2T-CHM13v2.0

Lyz2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	117,113,446 - 117,118,177 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	117,113,236 - 117,118,226 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	117,277,541 - 117,282,272 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	117,277,331 - 117,282,321 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	116,714,597 - 116,719,328 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	116,681,443 - 116,686,374 (-)	NCBI		MGSCv36	mm8
Celera	10	119,220,558 - 119,225,289 (-)	NCBI		Celera
Cytogenetic Map	10	D2	NCBI
cM Map	10	65.34	NCBI

Lyz2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	54,792,715 - 54,798,060 (-)	NCBI		GRCr8
mRatBN7.2	7	52,906,810 - 52,912,154 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	52,906,811 - 52,912,106 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	54,813,530 - 54,818,826 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	57,016,639 - 57,021,935 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	56,794,518 - 56,799,814 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	60,335,968 - 60,341,264 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	60,335,969 - 60,341,264 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	60,337,950 - 60,343,281 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	56,607,708 - 56,613,004 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	56,628,438 - 56,633,734 (-)	NCBI
Celera	7	49,680,647 - 49,685,943 (-)	NCBI		Celera
RH 3.4 Map	7	480.1	RGD
Cytogenetic Map	7	q22	NCBI

LYZ
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	11,346,500 - 11,350,639 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	11,346,435 - 11,351,040 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	11,278,390 - 11,282,529 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	11,469,702 - 11,473,856 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	11,469,637 - 11,474,257 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	11,337,085 - 11,341,219 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	11,583,952 - 11,588,107 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	11,706,255 - 11,710,386 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101959346
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	46,939,255 - 46,944,566 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936545	7,134,165 - 7,170,474 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936545	7,165,917 - 7,170,840 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LYZ
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	33,612,567 - 33,618,945 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	33,612,593 - 33,618,953 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	36,179,190 - 36,185,552 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	5	p11	NCBI

LYZ
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	64,978,153 - 64,984,351 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	64,978,119 - 64,984,495 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	180,708,862 - 180,715,047 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lyz
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624948	16,041 - 21,560 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624948	16,850 - 21,578 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003808722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH004924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000054955 ⟹ ENSPPAP00000032089

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	69,646,794 - 69,652,677 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000054962 ⟹ ENSPPAP00000032096

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	69,646,862 - 69,651,696 (+)	Ensembl

RefSeq Acc Id:

XM_003808722 ⟹ XP_003808770

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	77,375,766 - 77,381,645 (+)	NCBI
NHGRI_mPanPan1	12	77,372,162 - 77,378,043 (+)	NCBI
Mhudiblu_PPA_v0	12	66,870,373 - 66,876,250 (+)	NCBI
PanPan1.1	12	69,646,794 - 69,652,677 (+)	NCBI

Sequence:

show sequence

GTTAAAAGATGTTAAATACTGGGGCCAGCTCACCCTGGTCAGCCTAGCACTCTGACCTAGCAGT
CAACATGAAGGCTCTCATTGTTCTGGGGCTTGTCCTCCTTTCTGTTACCGTCCAGGGCAAGGTC
TTTGAAAGGTGTGAGTTGGCCAGAACTCTGAAAAGATTGGGAATGGATGGCTACAGGGGAATCA
GCCTAGCAAACTGGATGTGTTTGGCCAAATGGGAGAGTGGTTATAACACACGAGCTACAAACTA
CAATGCTGGAGACAGAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAAT
GATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTATCCTGCAGTGCTTTGCTGCAAGATA
ACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATG
GGTGGCATGGAGAAATCGTTGTCAAAACAGAGATGTCCGTCAGTATGTTCAAGGTTGTGGAGTA
TAACTCCAGAATTTTCCTTCTTCAGCTCATTTTGTCTCTCTCACATTAAGGGAGTAGTAATTAA
GTGAAAGGTCACACTACCATTATTTCCCCTTCAAACAAATAATATTTTTACAGAAGCAGGAGCA
AAATATGGCCTTTCTTCTAAGAGATATAATGTTCACTAATGTGGTTATTTTATATTAAGCCTAC
AACATTTTTCAGTTTGCAAATAGAACTAATACTGGTGAAAATTTACCTAAAACCTTGGTTATCA
AATACATCTCCAGTACATTCCATTCTTTTTTTTTTTTTTTTTTTTTGTAGACTAGTAGTCTTCG
CTCTGTCTACCCAGCTGGAGTGCATGCGCATCTCGGCTCACTGCAACCTCCACCTCCAGGTTCA
CGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACGGGCGCCCGCCACCACGCCCGGC
TAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCC
TGACCTTGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCG
CCCGGCCACATTCAGTTCTTATCAAAGAAATAACCCAGACTTAATCTTGAATGATACGATTATG
CCCAATATTAAGTAAAAAATATAAGAAAAGGTTATCTTAAATAGATCTTAGGCAAAATACCAGC
TGATGAAGGCATCTGATGCCTTCATCTGTTCAGTCATCTCCAAAAACAGTAAAAATAACCACTT
TTTGTTGGGCAATATGAAATTTTTAAAGGAGTAGAATACCAAATGATAGAAACAGACTGCCTGA
ATTGAGAATTCTGATTTCTTAAAGTGTGTTTCTTTCTAAATTGCTGTTCCTTAATTTGATTAAT
TTAATTCATGTATTATGATTAAATCTGAGGCAGATGAGCTTACAAGTATTGAAATAATTACTAA
TTAATCACAAATGTGAAGTTATGCATGATGTAAAAAATACAAACATTCTAATTAAAGGCTTTGC
AACACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003808770	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB41214	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032089
	ENSPPAP00000032089.1
	ENSPPAP00000032096.1
GenBank Protein	P61627	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_003808770 ⟸ XM_003808722
- UniProtKB:	P61627 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYN AGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWV AWRNRCQNRDVRQYVQGCGV hide sequence

RefSeq Acc Id:

ENSPPAP00000032096 ⟸ ENSPPAT00000054962

RefSeq Acc Id:

ENSPPAP00000032089 ⟸ ENSPPAT00000054955

Protein Domains

C-type lysozyme

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038937	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000054955.1	UniProtKB/Swiss-Prot
	ENSPPAT00000054962.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.530.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Glyco_hydro_22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glyco_hydro_22_CS	UniProtKB/Swiss-Prot
	Glyco_hydro_22_lys	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lysozyme-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	pps:100970943	UniProtKB/Swiss-Prot
NCBI Gene	LYZ	ENTREZGENE
PANTHER	PTHR11407	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11407:SF28	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Lys	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	LYSOZYME	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LYZLACT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	GLYCOSYL_HYDROL_F22_1	UniProtKB/Swiss-Prot
	GLYCOSYL_HYDROL_F22_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LYZ1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53955	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A2R9BRN4_PANPA	UniProtKB/TrEMBL
	LYSC_PANPA	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	P00695	UniProtKB/Swiss-Prot
	Q13170	UniProtKB/Swiss-Prot
	Q9UCF8	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM